PREB cdna clone

PREB cDNA Clone

Cat. Num. AAA1273225

• Gene Names: PREB; SEC12
• Synonyms: PREB; PREB cDNA Clone; PREB cdna clone

• Sequence: atgggccggcgccgggcgccagagctgtaccgggctccgttcccgttgtacgcgcttcaggtcgaccccagcactgggctgctcatcgctgcgggcggaggaggcgccgccaagacaggcataaagaatggcgtgcactttctgcagctagagctgattaatgggcgcttgagtgcctccttgctgcactcccatgacacagagacacgggccaccatgaacttggcactggctggtgacatccttgctgcagggcaggatgcccactgtcagctcctgcgcttccaggcacatcaacagcagggcaacaaggcagagaaggccggttccaaggagcaggggcctcgacaaaggaagggagcagccccagcagagaagaaatgtggagcggaaacccagcacgaggggctagaactcagggtagagaatttgcaggcggtgcagacagactttagctccgatccactgcagaaagttgtgtgcttcaaccacgataataccctgcttgccactggaggaacagatggctacgtccgtgtctggaaggtgcccagcctggagaaggttctggagttcaaagcccacgaaggggagattgaagacctggctttagggcctgatggcaagttggtaaccgtgggccgggaccttaaggcctctgtgtggcagaaggatcagctggtgacacagctgcactggcaagaaaatggacccaccttttccagcacaccttaccgctaccaggcctgcaggtttgggcaggttccagaccagcctgctggcctgcgactcttcacagtgcaaattccccacaagcgcctgcgccagccccctccctgctacctcacagcctgggatggctccaacttcttgccccttcggaccaagtcctgtggccatgaagtcgtctcctgcctcgatgtcagtgaatccggcaccttcctaggcctgggcacagtcactggctctgttgccatctacatagctttctctctccagtgcctctactacgtgagggaggcccatggcattgtggtgacggatgtggcctttctacctgagaagggtcgtggtccagagctccttgggtcccatgaaactgccctgttctctgtggctgtggacagtcgttgccagctgcatctgttgccctcacggcggagtgttcctgtgtggctcctgctcctgctgtgtgtcgggcttattattgtgaccatcctgctgctccagagtgcctttccaggtttcctttag
• Sequence Length: 1254

• Vector: pENTR223.1 or pUC
• Clone Sequence Report: Provided with product shipment

NCBI and Uniprot Product Information

• NCBI GI #: 33877147
• NCBI GeneID: 10113
• Molecular Weight: 45,468 Da
• NCBI Official Full Name: Homo sapiens prolactin regulatory element binding, mRNA
• NCBI Official Synonym Full Names: prolactin regulatory element binding
• NCBI Official Symbol: PREB
• NCBI Official Synonym Symbols: SEC12
• NCBI Protein Information: prolactin regulatory element-binding protein
• UniProt Protein Name: Prolactin regulatory element-binding protein
• Protein Family: Preblooming protein
• UniProt Gene Name: PREB
• UniProt Synonym Gene Names: SEC12
• UniProt Entry Name: PREB_HUMAN

NCBI Description

This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]

Uniprot Description

PREB: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.

Protein type: GEFs, misc.; Membrane protein, integral; Transcription factor

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane; nucleus

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Sar guanyl-nucleotide exchange factor activity

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; protein exit from endoplasmic reticulum