PREB cdna clone
PREB cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]
Uniprot Description
PREB: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.
Protein type: GEFs, misc.; Membrane protein, integral; Transcription factor
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane; nucleus
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Sar guanyl-nucleotide exchange factor activity
Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; protein exit from endoplasmic reticulum