PPP1R12A cdna clone
PPP1R12A cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Uniprot Description
MYPT1: myosin phosphatase target subunit 1, a regulatory subunit of protein phosphatase 1. Also called the myosin-binding subunit of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. Four splice-variant isoforms have been described.
Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q15-q21
Cellular Component: A band; actin cytoskeleton; centrosome; contractile fiber; cytoplasm; cytosol; focal adhesion; kinetochore; nucleoplasm; Z disc
Molecular Function: enzyme inhibitor activity; phosphatase regulator activity; protein binding; protein kinase binding
Biological Process: centrosome organization and biogenesis; G2/M transition of mitotic cell cycle; mitosis; negative regulation of catalytic activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; regulation of cell adhesion
Research Articles on PPP1R12A
Similar Products
Product Notes
The PPP1R12A ppp1r12a (Catalog #AAA1270778) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCAGATGG CGGACGCGAA GCAGAAGCGG AACGAGCAGC TGAAACGCTG GATCGGCTCC GAGACGGACC TCGAGCCTCC GGTGGTGAAG CGCCAGAAGA CCAAGGTGAA GTTCGACGAT GGCGCCGTCT TCCTGGCTGC TTGCTCCAGC GGCGACACGG ACGAGGTCCT CAAGCTGCTG CACCGCGGCG CCGACATCAA TTACGCCAAT GTGGACGGAC TCACTGCCCT GCACCAGGCT TGCATTGATG ACAATGTTGA TATGGTGAAG TTTCTGGTAG AAAATGGAGC AAATATTAAT CAACCTGATA ATGAAGGCTG GATACCACTA CATGCAGCAG CTTCCTGTGG ATATCTTGAT ATTGCAGAGT TTTTGATTGG TCAAGGAGCA CATGTAGGGG CTGTCAACAG TGAAGGAGAT ACACCTTTAG ATATTGCGGA GGAGGAGGCA ATGGAAGAGC TACTTCAAAA TGAAGTTAAT CGGCAAGGGG TTGATATAGA AGCAGCTCGA AAGGAAGAAG AACGGATCAT GCTTAGAGAT GCCAGGCAGT GGCTAAATAG TGGTCATATA AATGATGTCC GGCATGCAAA ATCTGGAGGT ACAGCACTTC ACGTTGCAGC TGCTAAAGGC TATACGGAAG TTTTAAAACT TTTAATACAG GCAGGCTATG ATGTTAATAT TAAAGACTAT GATGGCTGGA CACCTCTTCA TGCTGCAGCT CATTGGGGTA AAGAAGAAGC ATGTCGAATT TTAGTGGACA ATCTGTGTGA TATGGAGATG GTCAACAAAG TGGGCCAAAC AGCCTTTGAT GTAGCAGATG AAGACATTTT AGGATATTTA GAAGAGTTGC AAAAGAAACA AAATCTGCTC CATAGTGAAA AACGGGACAA GAAATCTCCA CTAATTGAAT CAACAGCAAA TATGGACAAT AATCAGTCAC AGAAGACCTT TAAAAACAAA GAGACGTTGA TTATTGAACC AGAGAAAAAT GCATCCCGTA TTGAATCTCT GGAACAAGAA AAGGTTGATG AAGAAGAAGA AGGAAAGAAG GATGAGTCTA GCTGCTCTAG TGAAGAAGAT GAGGAAGATG ACTCGGAATC AGAAGCTGAA ACAGATAAGA CAAAACCCCT GGCTTCTGTA ACTAATGCCA ACACTTCTAG TACACAAGCA GCTCCTGTAG CTGTTACAAC ACCTACTGTG TCATCAGGTC AAGCAACACC TACATCACCT ATTAAAAAGT TTCCAACCAC AGCTACAAAA ATTTCTCCCA AAGAAGAAGA GAGAAAAGAT GAGTCTCCTG CAACTTGGAG GTTAGGACTT AGAAAGACGG GCAGCTATGG TGCACTTGCT GAAATCACAG CATCTAAAGA GGGTCAGAAA GAAAAAGATA CTGCAGGTGT TACACGTTCA GCTTCAAGTC CCAGACTTTC CTCCTCTTTG GATAATAAAG AAAAGGAGAA AGATAGTAAA GGAACTAGGC TTGCATATGT TGCACCTACA ATACCAAGAC GACTAGCCAG TACATCTGAC ATTGAAGAGA AAGAAAACAG AGATTCTTCA AGTTTGCGAA CAAGTAGTTC ATATACAAGG AGAAAATGGG AAGATGATCT TAAAAAAAAT AGCTCAGTTA ATGAAGGATC AACGTATCAT AAAAGTTGCT CCTTTGGTAG AAGACAAGAT GATTTGATTA GTTCTAGTGT TCCAAGCACC ACATCAACAC CAACAGTTAC CTCTGCAGCT GGGCTTCAGA AAAGCCTGCT TTCCAGCACA AGCACTACTA CAAAGATTAC AACGGGTTCT TCCTCAGCAG GCACACAAAG CAGTACCTCA AATCGTTTGT GGGCTGAGGA TAGTACTGAG AAAGAAAAGG ACAGTGTTCC TACGGCAGTG ACCATTCCTG TTGCTCCAAC TGTTGTAAAT GCTGCAGCTT CTACCACAAC CCTGACTACA ACTACTGCTG GCACTGTCTC CTCCACAACA GAGGTCAGGG AGAGACGCAG ATCATACCTC ACTCCTGTTA GGGATGAAGA GTCTGAATCC CAAAGAAAAG CAAGATCTAG ACAAGCAAGA CAATCTAGAA GATCAACACA GGGAGTGACA TTAACTGATC TTCAAGAAGC TGAGAAAACA ATAGGAAGAA GTCGTTCTAC CCGAACCAGA GAACAAGAAA ATGAAGAAAA AGAAAAAGAG GAAAAAGAGA AACAAGATAA AGAGAAACAA GAAGAAAAGA AGGAGTCAGA AACATCTAGA GAAGATGAAT ATAAACAAAA GTACTCCAGA ACGTATGATG AGACTTACCA GCGTTATAGG CCAGTATCAA CTTCAAGTTC AACCACTCCA TCCTCTTCAC TTTCTACTAT GAGCAGTTCA CTGTATGCTT CAAGTCAACT AAACAGGCCA AATAGTCTTG TAGGCATAAC TTCTGCTTAC TCCAGAGGAA TAACAAAAGA AAATGAAAGA GAGGGAGAAA AAAGAGAAGA GGAGAAAGAA GGAGAAGATA AATCACAACC TAAATCAATC AGAGAACGAC GACGACCAAG AGAGAAAAGA AGATCTACAG GAGTTTCATT TTGGACACAA GATAGTGATG AAAATGAACA AGAACAACAA TCAGACACAG AAGAGGGATC CAATAAGAAA GAAACTCAGA CGGATTCCAT TTCTAGATAT GAAACCAGTT CTACATCAGC TGGTGATCGA TATGATTCCT TGCTGGGTCG CTCTGGATCA TACAGTTACT TAGAAGAAAG AAAACCTTAC AGCAGCAGGC TAGAAAAGGA TGACTCAACT GACTTTAAAA AGCTTTATGA ACAAATTCTA GCTGAAAATG AAAAGCTGAA GGCACAGCTA CATGATACAA ATATGGAACT AACAGATCTT AAATTACAGT TGGAAAAGGC CACCCAGAGA CAAGAAAGAT TTGCTGATAG ATCACTGTTG GAAATGGAAA AAAGGGAACG AAGAGCTCTA GAAAGAAGAA TATCTGAAAT GGAAGAAGAG CTCAAAATGT TACCAGACCT AAAAGCAGAC AACCAGAGGC TAAAGGATGA AAATGGGGCC TTGATCAGAG TTATAAGCAA ACTTTCCAAA TAA. It is sometimes possible for the material contained within the vial of "PPP1R12A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
