PLCB4 cdna clone
PLCB4 cDNA Clone
Gene Names
PLCB4; ARCND2; PI-PLC
Synonyms
PLCB4; PLCB4 cDNA Clone; PLCB4 cdna clone
Sequence
atggccaaaccttatgaatttaactggcagaaggaagttccctcctttttgcaagaaggaacagtttttgacagatacgaggaggaatcctttgtgtttgaacccaactgcctcttcaaagtggatgagtttggcttctttctgacatggagaagtgaaggcaaggaaggacaggtgctagaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttggctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtctgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaagtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaacgtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacacaaatggtaaaattccagttaggagtattactagaacatttgcatcgggaaaaacagaaaaggtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgagcccacagcattttcttatgaaaagttctatgaactgacacaaaagatttgtcctcggacagatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagaccaattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttatttccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagatttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaaaacgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggctcactacttcatcagttcttcccataacacttatctcactggcagacagttcggcgggaagtcttcggtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgactgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgtacagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatcagaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatgtccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacatccacttgaaccaggcagggctttgccatcccccaatgacctcaaaagaaaaatactcataaaaaacaagcggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatgatggaagctggagaatctgcctccccagcaaacatcttagaggacgataatgaagaggagatcgaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactttctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaagggcctggtcactgtagaagatgagcaggcgtggatggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatgatcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatattcattataacatgtcttcttttaatgaatcagtcggtcttggctacttgaagacacatgcaattgaatttgtcaattataacaaacggcaaatgagtcgcatttaccccaagggaggccgagtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcactgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataatggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgaccccttctctgaaactcctgttgatggtgttattgcagccacttgctcagtgcaggttatatcaggtcaattcttatcagataagaaaattggcacctacgtagaggtggatatgtatgggttgcccactgacaccatacgtaaggaattccgaactcgcatggttatgaataatggactcaatccagtttacaatgaagagtcatttgtatttcggaaggtgatcctgccggacctggctgtcttgagaatagctgtgtatgatgataacaacaagctgattggccagaggatcctcccgcttgatggcctccaagccggatatcgacacatttcccttcgaaatgagggaaataaaccattatcactaccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggatttggagatatcgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagagagcagaccaaatgagagctatgggcattgaaactagtgacatagccgacgtgcccagtgacacttccaaaaatgacaagaaaggaaaggccaacaccgccaaagcaaatgtgacccctcagagtagctctgagctcagaccaaccaccacggctgccctggcctctggtgtggaagccaagaaaggtattgaacttatccctcaagtaaggatagaagacttaaagcagatgaaggcttacttgaagcatttaaagaaacagcagaaggagctaaattctttaaagaagaaacatgcaaaggaacacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtatgacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaaggggggaagtaattgtctcgaaatgaaaaaagaaacagaaatcaaaattcagacgctgacatcagatcacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatcaatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgagctgctgaaaaagctactcatcaatgcccacgagcagcaaacccagcagctgaaactgtcccatgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagcaaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgagtcagggagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagacttgccatgaagcagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagagaaacagaatgagcaggcgaaggagatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatga
Sequence Length
3528
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
135,845 Da
NCBI Official Full Name
Homo sapiens phospholipase C, beta 4, mRNA
NCBI Official Synonym Full Names
phospholipase C beta 4
NCBI Official Symbol
PLCB4
NCBI Official Synonym Symbols
ARCND2; PI-PLC
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Protein Family
UniProt Gene Name
PLCB4
UniProt Synonym Gene Names
PLC-beta-4
UniProt Entry Name
PLCB4_HUMAN
NCBI Description
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Uniprot Description
PLCB4: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. Defects in PLCB4 are the cause of auriculocondylar syndrome type 2 (ARCND2). ARCND2 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.4.11; Phospholipase; Carbohydrate Metabolism - inositol phosphate
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: cytosol
Molecular Function: phosphoinositide phospholipase C activity; phospholipase C activity; protein binding
Biological Process: inositol phosphate metabolic process
Disease: Auriculocondylar Syndrome 2
Research Articles on PLCB4
Similar Products
Product Notes
The PLCB4 plcb4 (Catalog #AAA1270195) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccaaac cttatgaatt taactggcag aaggaagttc cctccttttt gcaagaagga acagtttttg acagatacga ggaggaatcc tttgtgtttg aacccaactg cctcttcaaa gtggatgagt ttggcttctt tctgacatgg agaagtgaag gcaaggaagg acaggtgcta gaatgctccc tcatcaacag tattcggtcg ggagccatac caaaggatcc caaaatcttg gctgctcttg aagctgttgg aaaatcagaa aatgatctgg aagggcggat agtttgtgtc tgcagtggca cagatctagt gaacattagt tttacctaca tggtggctga aaatccagaa gtaactaagc aatgggtaga aggcctgaga tcaatcatac acaacttcag ggccaacaac gtcagtccaa tgacatgcct caagaaacac tggatgaaat tggcatttat gaccaacaca aatggtaaaa ttccagttag gagtattact agaacatttg catcgggaaa aacagaaaag gtgatctttc aagcactcaa ggagttaggt cttcccagtg gaaagaatga tgaaattgag cccacagcat tttcttatga aaagttctat gaactgacac aaaagatttg tcctcggaca gatatagaag atcttttcaa aaaaatcaat ggagacaaaa ctgattattt aacggtagac caattagtga gctttctaaa tgaacatcaa cgagatcctc gattgaatga aattttattt ccattttatg atgccaaaag ggcaatgcag atcattgaga tgtatgaacc tgatgaagat ttgaagaaaa aaggccttat atcaagtgat gggttttgca gatatctgat gtcagatgaa aacgccccag tcttcctaga tcgtttagaa ctttaccaag aaatggacca tcctctggct cactacttca tcagttcttc ccataacact tatctcactg gcagacagtt cggcgggaag tcttcggtag aaatgtacag acaggttctc ctggctggtt gcagatgtgt tgaacttgac tgctgggatg gaaaaggtga agaccaagaa ccaataataa ctcatggaaa agcaatgtgt acagatatcc tttttaagga tgtaattcaa gccatcaagg aaactgcatt tgtcacatca gaatatcctg taattctctc ctttgaaaat cactgcagca aatatcaaca gtacaagatg tccaaatatt gcgaagatct atttggggat ctcctgttga aacaagcact tgaatcacat ccacttgaac caggcagggc tttgccatcc cccaatgacc tcaaaagaaa aatactcata aaaaacaagc ggctgaaacc tgaagttgaa aaaaaacagc tggaagcttt gagaagcatg atggaagctg gagaatctgc ctccccagca aacatcttag aggacgataa tgaagaggag atcgaaagtg ctgaccaaga ggaggaagct caccccgaat tcaaatttgg aaatgaactt tctgctgatg acttgggtca caaggaagct gttgcaaata gcgtcaagaa gggcctggtc actgtagaag atgagcaggc gtggatggca tcttataaat atgtaggtgc taccactaat atccatccat atttgtccac aatgatcaac tacgcccagc ctgtaaagtt tcaaggtttc catgtggcag aagaacgcaa tattcattat aacatgtctt cttttaatga atcagtcggt cttggctact tgaagacaca tgcaattgaa tttgtcaatt ataacaaacg gcaaatgagt cgcatttacc ccaagggagg ccgagtcgat tccagtaatt acatgcctca gattttctgg aacgctggct gccagatggt ttcactgaac tatcaaaccc cagatttagc gatgcaattg aatcagggaa aatttgagta taatggatcg tgcgggtacc ttctcaaacc agatttcatg aggcggcctg atcgaacatt tgaccccttc tctgaaactc ctgttgatgg tgttattgca gccacttgct cagtgcaggt tatatcaggt caattcttat cagataagaa aattggcacc tacgtagagg tggatatgta tgggttgccc actgacacca tacgtaagga attccgaact cgcatggtta tgaataatgg actcaatcca gtttacaatg aagagtcatt tgtatttcgg aaggtgatcc tgccggacct ggctgtcttg agaatagctg tgtatgatga taacaacaag ctgattggcc agaggatcct cccgcttgat ggcctccaag ccggatatcg acacatttcc cttcgaaatg agggaaataa accattatca ctaccaacaa ttttctgcaa tattgttctt aaaacatatg tgcctgatgg atttggagat atcgtggatg ctttatcaga tccaaagaaa tttctctcaa ttacagaaaa gagagcagac caaatgagag ctatgggcat tgaaactagt gacatagccg acgtgcccag tgacacttcc aaaaatgaca agaaaggaaa ggccaacacc gccaaagcaa atgtgacccc tcagagtagc tctgagctca gaccaaccac cacggctgcc ctggcctctg gtgtggaagc caagaaaggt attgaactta tccctcaagt aaggatagaa gacttaaagc agatgaaggc ttacttgaag catttaaaga aacagcagaa ggagctaaat tctttaaaga agaaacatgc aaaggaacac agtaccatgc agaagttaca ctgcacgcaa gttgacaaaa ttgtggcaca gtatgacaaa gagaagtcga ctcatgagaa aatcctagag aaggcaatga agaagaaggg gggaagtaat tgtctcgaaa tgaaaaaaga aacagaaatc aaaattcaga cgctgacatc agatcacaaa tctaaggtca aagagattgt agcacagcac acaaaggaat ggtcagaaat gatcaatacc cacagtgctg aggagcaaga aatccgagac ctgcacctca gccagcagtg tgagctgctg aaaaagctac tcatcaatgc ccacgagcag caaacccagc agctgaaact gtcccatgac agggaaagca aggaaatgcg agcacaccag gctaagattt ctatggaaaa tagcaaagcc atcagccaag ataaatctat caagaataaa gcagaacggg aaaggcgagt cagggagtta aacagcagca acactaaaaa gtttctggaa gaaagaaaga gacttgccat gaagcagtcc aaagaaatgg atcagttgaa aaaagtccag cttgaacatc tagaattcct agagaaacag aatgagcagg cgaaggagat gcagcagatg gtgaaattgg aagccgagat ggaccgcaga ccagcaacag tagtatga. It is sometimes possible for the material contained within the vial of "PLCB4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
