PLCB1 cdna clone
PLCB1 cDNA Clone
Gene Names
PLCB1; PLC-I; EIEE12; PI-PLC; PLC154; PLCB1A; PLCB1B; PLC-154; PLC-beta-1
Synonyms
PLCB1; PLCB1 cDNA Clone; PLCB1 cdna clone
Sequence
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgacagcctcaagaagggcaccaaattcgtcaagtgggatgatgactcaactattgttactccaattattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggagacagagctactggatctcagccttgtcaaagatgccagatgtgggagacacgccaaagctcccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcagcgcatgatcacagtggtgtatgggcctgacctcgtgaacatctcccatttgaatctcgtggctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaacctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaagctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagcagatcggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgattcaatacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgccctcgacctgaaattgataacatcttttcagaatttggtgcaaaaagcaaaccatatcttaccgttgatcagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaaatactttatccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaacccaacaacagcctcgccagaaaaggacaaatatcagtggatgggttcatgcgctatctgagtggagaagaaaacggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcagcccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactggctggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtggagctggactgctggaagggacggactgcagaagaggaacctgtcatcacccatggcttcaccatgacaactgaaatatctttcaaggaagtgatagaagcaattgcggagtgtgcatttaagacttcaccttttccaattctcctttcgtttgagaaccatgtggattccccaaagcagcaagccaagatggcggagtactgccgactgatctttggggatgcccttctcatggagcccctggaaaaatatccactggaatctggagttcctcttccaagccctatggatttaatgtataaaattttggtgaaaaataagaagaaatcacacaagtcatcagaaggaagcggcaaaaagaagctctcagaacaagcctccaacacctacagtgactcctccagcatgttcgagccctcatccccaggagccggagaagctgatacggaaagtgacgacgacgatgatgatgatgactgtaaaaaatcttcaatggatgaggggactgctggaagtgaggctatggccacagaagaaatgtctaatctggtgaactatattcagccagtcaagtttgagtcatttgaaatttcaaaaaaaagaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcaccaagtctccagtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaaggaacacgtgtggattcatccaactatatgcctcagctcttctggaatgcaggttgtcagatggtggcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtatgaatacaacgggaagagtggctacagattgaagccagagttcatgaggaggcctgacaagcattttgatccatttactgaaggcatcgtagatgggatagtggcaaacactttgtctgttaagattatttcaggtcagtttctttctgataagaaagttgggacttacgtggaagtagatatgtttggtttgcctgtggatacaaggaggaaggcatttaagaccaaaacatcccaaggaaatgctgtgaatcctgtctgggaagaagaacctattgtgttcaaaaaggtggttcttcctactctggcctgtttgagaatagcagtttatgaagaaggaggtaaattcattggccaccgtatcttgccagtgcaagccattcggccaggctatcactatatctgtctaaggaatgaaaggaaccagcctctgacgctgcctgctgtctttgtctacatagaagtgaaagactatgtgccagacacatatgcagatgtcatcgaagctttatcaaacccaatccgatatgtgaacctgatggaacagagagctaagcaattggctgctttgacactggaagatgaagaagaagtaaagaaagaggctgatcctggagaaacaccatcagaggctccaagtgaagcgagaacgactccagcagaaaatggggtgaatcacactacaaccctgacacccaagccaccctcccaggctctccacagccagccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagtgtcttaacagaagtggaagcacagaccatcgaagaactaaagcaacagaaatcgtttgtgaaacttcaaaagaaacactacaaagaaatgaaagacctggttaagagacaccacaagaaaaccactgaccttatcaaagaacacactaccaagtataatgaaattcagaatgactacttgagaaggagagccgctttggaaaagtccgccaaaaaggacagtaagaaaaaatcggaacccagcagccctgatcatggttcatcaacgattgagcaagacctcgctgccctggatgctgaaatgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcggcaagaacagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaaaagttgacggatgtcgcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatctgtgagaaagaaaagaaagaattaaagaagaaaatggataaaaagaggcaggagaagataacagaagctaaatccaaagacaaaagtcagatggaagaggagaagacagagatgatccggtcatatatccaggaagtggtgcagtatatcaagaggctagaagaagcgcaaagtaaacggcaagaaaaactcgtagagaaacacaaggaaatacgtcagcagatcctggatgaaaagcccaagctgcaggtggagctggagcaagaataccaagacaaattcaaaagactgcccctcgagattttggaattcgtgcaggaagccatgaaaggaaagatcagtgaagacagcaatcacggttctgcccctctctccctgtcctcagaccctggaaaagtgaaccacaagactccctccagtgaggagctgggaggagacatcccaggaaaagaatttgatactcctctgtga
Sequence Length
3651
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
138,567 Da
NCBI Official Full Name
Homo sapiens phospholipase C, beta 1 (phosphoinositide-specific), mRNA
NCBI Official Synonym Full Names
phospholipase C beta 1
NCBI Official Symbol
PLCB1
NCBI Official Synonym Symbols
PLC-I; EIEE12; PI-PLC; PLC154; PLCB1A; PLCB1B; PLC-154; PLC-beta-1
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Protein Family
UniProt Gene Name
PLCB1
UniProt Synonym Gene Names
KIAA0581; PLC-I; PLC-beta-1
UniProt Entry Name
PLCB1_HUMAN
NCBI Description
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PLCB1: an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Binds to calmodulin. Uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variant isoforms have been described.
Protein type: Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nuclear speck
Molecular Function: calmodulin binding; enzyme binding; GTPase activator activity; phosphatidylinositol-4,5-bisphosphate binding; phosphoinositide phospholipase C activity; protein binding; protein homodimerization activity
Biological Process: acetylcholine receptor signaling, muscarinic pathway; cerebral cortex development; G2/M transition of mitotic cell cycle; glutamate signaling pathway; inositol phosphate metabolic process; insulin-like growth factor receptor signaling pathway; memory; negative regulation of transcription, DNA-dependent; phosphatidylinositol metabolic process; positive regulation of developmental growth; positive regulation of embryonic development; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of myoblast differentiation; positive regulation of transcription, DNA-dependent; regulation of G-protein coupled receptor protein signaling pathway; Wnt receptor signaling pathway, calcium modulating pathway
Disease: Epileptic Encephalopathy, Early Infantile, 12
Research Articles on PLCB1
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Product Notes
The PLCB1 plcb1 (Catalog #AAA1272690) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccgggg ctcaacccgg agtgcacgcc ttgcaactca agcccgtgtg cgtgtccgac agcctcaaga agggcaccaa attcgtcaag tgggatgatg actcaactat tgttactcca attattttga ggactgaccc tcagggattt ttcttttact ggacagatca aaacaaggag acagagctac tggatctcag ccttgtcaaa gatgccagat gtgggagaca cgccaaagct cccaaggacc ccaaattacg tgaacttttg gatgtgggga acatcgggcg cctggagcag cgcatgatca cagtggtgta tgggcctgac ctcgtgaaca tctcccattt gaatctcgtg gctttccaag aagaagtggc caaggaatgg acaaatgagg ttttcagttt ggcaacaaac ctgctggccc aaaacatgtc cagggatgca tttctggaaa aagcctatac taaacttaag ctgcaagtca ctccagaagg gcgtattcct ctcaaaaaca tatatcgctt gttttcagca gatcggaagc gagttgaaac tgctttagag gcttgtagtc ttccatcttc aaggaatgat tcaatacctc aagaagattt cactccagaa gtgtacagag ttttcctcaa caacctttgc cctcgacctg aaattgataa catcttttca gaatttggtg caaaaagcaa accatatctt accgttgatc agatgatgga ttttatcaac cttaagcagc gagatcctcg gcttaatgaa atactttatc cacctctaaa acaagagcaa gtccaagtat tgattgagaa gtatgaaccc aacaacagcc tcgccagaaa aggacaaata tcagtggatg ggttcatgcg ctatctgagt ggagaagaaa acggagtcgt ttcacctgag aaactggatt tgaatgaaga catgtctcag cccctttctc actatttcat taattcctcg cacaacacct acctcacagc tggccaactg gctggaaact cctctgttga gatgtatcgc caagtgctcc tgtctggttg tcgctgtgtg gagctggact gctggaaggg acggactgca gaagaggaac ctgtcatcac ccatggcttc accatgacaa ctgaaatatc tttcaaggaa gtgatagaag caattgcgga gtgtgcattt aagacttcac cttttccaat tctcctttcg tttgagaacc atgtggattc cccaaagcag caagccaaga tggcggagta ctgccgactg atctttgggg atgcccttct catggagccc ctggaaaaat atccactgga atctggagtt cctcttccaa gccctatgga tttaatgtat aaaattttgg tgaaaaataa gaagaaatca cacaagtcat cagaaggaag cggcaaaaag aagctctcag aacaagcctc caacacctac agtgactcct ccagcatgtt cgagccctca tccccaggag ccggagaagc tgatacggaa agtgacgacg acgatgatga tgatgactgt aaaaaatctt caatggatga ggggactgct ggaagtgagg ctatggccac agaagaaatg tctaatctgg tgaactatat tcagccagtc aagtttgagt catttgaaat ttcaaaaaaa agaaataaaa gttttgaaat gtcttccttc gtggaaacca aaggacttga acaactcacc aagtctccag tggaatttgt agaatataac aaaatgcagc ttagcaggat atatccaaaa ggaacacgtg tggattcatc caactatatg cctcagctct tctggaatgc aggttgtcag atggtggcac ttaatttcca gacaatggac ctggctatgc aaataaatat ggggatgtat gaatacaacg ggaagagtgg ctacagattg aagccagagt tcatgaggag gcctgacaag cattttgatc catttactga aggcatcgta gatgggatag tggcaaacac tttgtctgtt aagattattt caggtcagtt tctttctgat aagaaagttg ggacttacgt ggaagtagat atgtttggtt tgcctgtgga tacaaggagg aaggcattta agaccaaaac atcccaagga aatgctgtga atcctgtctg ggaagaagaa cctattgtgt tcaaaaaggt ggttcttcct actctggcct gtttgagaat agcagtttat gaagaaggag gtaaattcat tggccaccgt atcttgccag tgcaagccat tcggccaggc tatcactata tctgtctaag gaatgaaagg aaccagcctc tgacgctgcc tgctgtcttt gtctacatag aagtgaaaga ctatgtgcca gacacatatg cagatgtcat cgaagcttta tcaaacccaa tccgatatgt gaacctgatg gaacagagag ctaagcaatt ggctgctttg acactggaag atgaagaaga agtaaagaaa gaggctgatc ctggagaaac accatcagag gctccaagtg aagcgagaac gactccagca gaaaatgggg tgaatcacac tacaaccctg acacccaagc caccctccca ggctctccac agccagccag ctccaggttc tgtaaaggca cctgccaaaa cagaagatct tattcagagt gtcttaacag aagtggaagc acagaccatc gaagaactaa agcaacagaa atcgtttgtg aaacttcaaa agaaacacta caaagaaatg aaagacctgg ttaagagaca ccacaagaaa accactgacc ttatcaaaga acacactacc aagtataatg aaattcagaa tgactacttg agaaggagag ccgctttgga aaagtccgcc aaaaaggaca gtaagaaaaa atcggaaccc agcagccctg atcatggttc atcaacgatt gagcaagacc tcgctgccct ggatgctgaa atgacccaaa agttaataga cttgaaggac aaacaacagc agcagctgct taatcttcgg caagaacagt attatagtga aaaataccag aagcgagaac atattaaact gcttattcaa aagttgacgg atgtcgcaga agagtgtcag aacaatcagt taaagaagct caaagaaatc tgtgagaaag aaaagaaaga attaaagaag aaaatggata aaaagaggca ggagaagata acagaagcta aatccaaaga caaaagtcag atggaagagg agaagacaga gatgatccgg tcatatatcc aggaagtggt gcagtatatc aagaggctag aagaagcgca aagtaaacgg caagaaaaac tcgtagagaa acacaaggaa atacgtcagc agatcctgga tgaaaagccc aagctgcagg tggagctgga gcaagaatac caagacaaat tcaaaagact gcccctcgag attttggaat tcgtgcagga agccatgaaa ggaaagatca gtgaagacag caatcacggt tctgcccctc tctccctgtc ctcagaccct ggaaaagtga accacaagac tccctccagt gaggagctgg gaggagacat cccaggaaaa gaatttgata ctcctctgtg a. It is sometimes possible for the material contained within the vial of "PLCB1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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