PLAUR cdna clone
PLAUR cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
Uniprot Description
uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, GPI anchor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane; extrinsic to membrane; focal adhesion; plasma membrane
Molecular Function: enzyme binding; protein binding; protein domain specific binding; receptor binding; U-plasminogen activator receptor activity
Biological Process: attachment of GPI anchor to protein; chemotaxis; fibrinolysis; negative regulation of apoptosis; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein amino acid phosphorylation; signal transduction
Research Articles on PLAUR
Similar Products
Product Notes
The PLAUR plaur (Catalog #AAA1272068) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggtcacc cgccgctgct gccgctgctg ctgctgctcc acacctgcgt cccagcctct tggggcctgc ggtgcatgca gtgtaagacc aacggggatt gccgtgtgga agagtgcgcc ctgggacagg acctctgcag gaccacgatc gtgcgcttgt gggaagaagg agaagagctg gagctggtgg agaaaagctg tacccactca gagaagacca acaggaccct gagctatcgg actggcttga agatcaccag ccttaccgag gttgtgtgtg ggttagactt gtgcaaccag ggcaactctg gccgggctgt cacctattcc cgaagccgtt acctcgaatg catttcctgt ggctcatcag acatgagctg tgagaggggc cggcaccaga gcctgcagtg ccgcagccct gaagaacagt gcctggatgt ggtgacccac tggatccagg aaggtgaaga agggcgtcca aaggatgacc gccacctccg tggctgtggc taccttcccg gctgcccggg ctccaatggt ttccacaaca acgacacctt ccacttcctg aaatgctgca acaccaccaa atgcaacgag ggcccaatcc tggagcttga aaatctgccg cagaatggcc gccagtgtta cagctgcaag gggaacagca cccatggatg ctcctctgaa gagactttcc tcattgactg ccgaggcccc atgaatcaat gtctggtagc caccggcact cacgaaccga aaaaccaaag ctatatggta agaggctgtg caaccgcctc aatgtgccaa catgcccacc tgggtgacgc cttcagcatg aaccacattg atgtctcctg ctgtactaaa agtggctgta accacccaga cctggatgtc cagtaccgca gtggggctgc tcctcagcct ggccctgccc atctcagcct caccatcacc ctgctaatga ctgccagact gtggggaggc actctcctct ggacctaa. It is sometimes possible for the material contained within the vial of "PLAUR, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
