PIK3CA cdna clone
PIK3CA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]
Uniprot Description
PIK3CA: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1- AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with IRS1 in nuclear extracts. Interacts with RUFY3. Interacts with RASD2. Interacts with APPL1. Interacts with HRAS1 and KRAS. Interaction with HRAS1/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2. Belongs to the PI3/PI4-kinase family.
Protein type: EC 2.7.1.153; Oncoprotein; Motility/polarity/chemotaxis; EC 2.7.11.1; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid
Chromosomal Location of Human Ortholog: 3q26.3
Cellular Component: cytosol; phosphoinositide 3-kinase complex; plasma membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; protein binding
Biological Process: cardiac muscle contraction; endothelial cell migration; epidermal growth factor receptor signaling pathway; leukocyte migration; phosphatidylinositol biosynthetic process; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; platelet activation; regulation of phosphoinositide 3-kinase cascade; T cell costimulation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vasculature development
Disease: Breast Cancer; Colorectal Cancer; Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi; Cowden Syndrome 5; Gastric Cancer; Hepatocellular Carcinoma; Keratosis, Seborrheic; Lung Cancer; Megalencephaly-capillary Malformation-polymicrogyria Syndrome; Nevus, Epidermal; Ovarian Cancer
Research Articles on PIK3CA
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Product Notes
The PIK3CA pik3ca (Catalog #AAA1267033) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcctccac gaccatcatc aggtgaactg tggggcatcc acttgatgcc cccaagaatc ctagtagaat gtttactacc aaatggaatg atagtgactt tagaatgcct ccgtgaggct acattaataa ccataaagca tgaactattt aaagaagcaa gaaaataccc cctccatcaa cttcttcaag atgaatcttc ttacattttc gtaagtgtta ctcaagaagc agaaagggaa gaattttttg atgaaacaag acgactttgt gaccttcggc tttttcaacc ctttttaaaa gtaattgaac cagtaggcaa ccgtgaagaa aagatcctca atcgagaaat tggttttgct atcggcatgc cagtgtgtga atttgatatg gttaaagatc cagaagtaca ggacttccga agaaatattc tgaacgtttg taaagaagct gtggatctta gggacctcaa ttcacctcat agtagagcaa tgtatgtcta tcctccaaat gtagaatctt caccagaatt gccaaagcac atatataata aattagataa agggcaaata atagtggtga tctgggtaat agtttctcca aataatgaca agcagaagta tactctgaaa atcaaccatg actgtgtacc agaacaagta attgctgaag caatcaggaa aaaaactcga agtatgttgc tatcctctga acaactaaaa ctctgtgttt tagaatatca gggcaagtat attttaaaag tgtgtggatg tgatgaatac ttcctagaaa aatatcctct gagtcagtat aagtatataa gaagctgtat aatgcttggg aggatgccca atttgatgtt gatggctaaa gaaagccttt attctcaact gccaatggac tgttttacaa tgccatctta ttccagacgc atttccacag ctacaccata tatgaatgga gaaacatcta caaaatccct ttgggttata aatagtgcac tcagaataaa aattctttgt gcaacctacg tgaatgtaaa tattcgagac attgataaga tctatgttcg aacaggtatc taccatggag gagaaccctt atgtgacaat gtgaacactc aaagagtacc ttgttccaat cccaggtgga atgaatggct gaattatgat atatacattc ctgatcttcc tcgtgctgct cgactttgcc tttccatttg ctctgttaaa ggccgaaagg gtgctaaaga ggaacactgt ccattggcat ggggaaatat aaacttgttt gattacacag acactctagt atctggaaaa atggctttga atctttggcc agtacctcat ggattagaag atttgctgaa ccctattggt gttactggat caaatccaaa taaagaaact ccatgcttag agttggagtt tgactggttc agcagtgtgg taaagttccc agatatgtca gtgattgaag agcatgccaa ttggtctgta tcccgagaag caggatttag ctattcccac gcaggactga gtaacagact agctagagac aatgaattaa gggaaaatga caaagaacag ctcaaagcaa tttctacacg agatcctctc tctgaaatca ctgagcagga gaaagatttt ctatggagtc acagacacta ttgtgtaact atccccgaaa ttctacccaa attgcttctg tctgttaaat ggaattctag agatgaagta gcccagatgt attgcttggt aaaagattgg cctccaatca aacctgaaca ggctatggaa cttctggact gtaattaccc agatcctatg gttcgaggtt ttgctgttcg gtgcttggaa aaatatttaa cagatgacaa actttctcag tatttaattc agctagtaca ggtcctaaaa tatgaacaat atttggataa cttgcttgtg agatttttac tgaagaaagc attgactaat caaaggattg ggcacttttt cttttggcat ttaaaatctg agatgcacaa taaaacagtt agccagaggt ttggcctgct tttggagtcc tattgtcgtg catgtgggat gtatttgaag cacctgaata ggcaagtcga ggcaatggaa aagctcatta acttaactga cattctcaaa caggagaaga aggatgaaac acaaaaggta cagatgaagt ttttagttga gcaaatgagg cgaccagatt tcatggatgc tctacagggc tttctgtctc ctctaaaccc tgctcatcaa ctaggaaacc tcaggcttga agagtgtcga attatgtcct ctgcaaaaag gccactgtgg ttgaattggg agaacccaga catcatgtca gagttactgt ttcagaacaa tgagatcatc tttaaaaatg gggatgattt acggcaagat atgctaacac ttcaaattat tcgtattatg gaaaatatct ggcaaaatca aggtcttgat cttcgaatgt taccttatgg ttgtctgtca atcggtgact gtgtgggact tattgaggtg gtgcgaaatt ctcacactat tatgcaaatt cagtgcaaag gcggcttgaa aggtgcactg cagttcaaca gccacacact acatcagtgg ctcaaagaca agaacaaagg agaaatatat gatgcagcca ttgacctgtt tacacgttca tgtgctggat actgtgtagc taccttcatt ttgggaattg gagatcgtca caatagtaac atcatggtga aagacgatgg acaactgttt catatagatt ttggacactt tttggatcac aagaagaaaa aatttggtta taaacgagaa cgtgtgccat ttgttttgac acaggatttc ttaatagtga ttagtaaagg agcccaagaa tgcacaaaga caagagaatt tgagaggttt caggagatgt gttacaaggc ttatctagct attcgacagc atgccaatct cttcataaat cttttctcaa tgatgcttgg ctctggaatg ccagaactac aatcttttga tgacattgca tacattcgaa agaccctagc cttagataaa actgagcaag aggctttgga gtatttcatg aaacaaatga atgatgcaca tcatggtggc tggacaacaa aaatggattg gatcttccac acaattaaac agcatgcatt gaactga. It is sometimes possible for the material contained within the vial of "PIK3CA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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