PIK3C2A cdna clone
PIK3C2A cDNA Clone
Gene Names
PIK3C2A; CPK; PI3-K-C2A; PI3K-C2alpha; PI3K-C2-alpha; PI3-K-C2(ALPHA)
Synonyms
PIK3C2A; PIK3C2A cDNA Clone; PIK3C2A cdna clone
Sequence
atggctcagatatctagcaacagcggatttaaagaatgtccatcttcacatccggaaccaacaagagcaaaagatgtggacaaagaagaagcattacagatggaagcagaggctttagcaaaactgcaaaaggatagacaagtgactgacaatcagagaggctttgagttgtcaagcagcaccagaaaaaaagcacaggtttataacaagcaggattatgatctcatggtgtttcctgaatcagattcccaaaaaagagcattagatattgatgtagaaaagctcacccaagctgaacttgagaaactattgctggatgacagtttcgagactaaaaaaacacctgtattaccagttactcctattctgagcccttccttttcagcacagctctattttagacctactattcagagaggacagtggccacctggattacctgggccttccacttatgctttaccttctatttatccttctacttacagtaaacaggctgcattccaaaatggcttcaatccaagaatgcccacttttccatctacagaacctatatatttaagtcttccgggacaatctccatatttctcatatcctttgacacctgccacaccctttcatccacaaggaagcttacctatctatcgtccagtagtcagtactgacatggcaaaactatttgacaaaatagctagtacatcagaatttttaaaaaatgggaaagcaaggactgatttggagataacagattcaaaagtcagcaatctacaggtatctccaaagtctgaggatatcagtaaatttgactggttagacttggatcctctaagtaagcctaaggtggataatgtggaggtattagaccatgaggaagagaaaaatgtttcaagtttgctagcaaaggatccttgggatgctgttcttcttgaagagagatcgacagcaaattgtcatcttgaaagaaaggtgaatggaaaatccctttctgtggcaactgttacaagaagccagtctttaaatattcgaacaactcagcttgcaaaagcccagggccatatatctcagaaagacccaaatgggaccagtagtttgccaactggaagttctcttcttcaagaagttgaagtacagaatgaggagatggcagctttttgtcgatccattacaaaattgaagaccaaatttccatataccaatcaccgcacaaacccaggctatttgttaagtccagtcacagcgcaaagaaacatatgcggagaaaatgctagtgtgaaggtctccattgacattgaaggatttcagctaccagttacttttacgtgtgatgtgagttctactgtagaaatcattataatgcaagccctttgctgggtacatgatgacttgaatcaagtagatgttggcagctatgttctaaaagtttgtggtcaagaggaagtgctgcagaataatcattgccttggaagtcatgagcatattcaaaactgtcgaaaatgggacacagaaattagactacaactcttgaccttcagtgcaatgtgtcaaaatctggcccgaacagcagaagatgatgaaacacccgtggatttaaacaaacacctgtatcaaatagaaaaaccttgcaaagaagccatgacgagacaccctgttgaagaactcttagattcttatcacaaccaagtagaactggctcttcaaattgaaaaccaacaccgagcagtagatcaagtaattaaagctgtaagaaaaatctgtagtgctttagatggtgtcgagactcttgccattacagaatcagtaaagaagctaaagagagcagttaatcttccaaggagtaaaactgctgatgtgacttctttgtttggaggagaagacactagcaggagttcaactaggggctcacttaatcctgaaaatcctgttcaagtaagcataaaccaattaactgcagcaatttatgatcttctcagactccatgcaaattctggtaggagtcctacagactgtgcccaaagtagcaagagtgtcaaggaagcatggactacaacagagcagctccagtttactatttttgctgctcatggaatttcaagtaattgggtatcaaattatgaaaaatactacttgatatgttcactgtctcacaatggaaaggatctttttaaacctattcaatcaaagaaggttggcacttacaagaatttcttctatcttattaaatgggatgaactaatcatttttcctatccagatatcacaattgccattagaatcagttcttcaccttactctttttggaattttaaatcagagcagtggaagttcccctgattctaataagcagagaaagggaccagaagctttgggcaaagtttctttacctctttttgactttaaacggtttttaacatgtggaactaaacttctatatctttggacttcatcacatacaaattctgttcctggaacagttaccaaaaaaggatatgtcatggaaagaatagtgctacaggttgattttccttctcctgcatttgatattatttatacaactcctcaagttgacagaagcattatacagcaacataacttagaaacactagagaatgatataaaagggaaacttcttgatattcttcataaagactcatcacttggactttctaaagaagataaagcttttttatgggagaaacgttattattgcttcaaacacccaaattgtcttcctaaaatattagcaagcgccccaaactggaaatgggttaatcttgccaaaacttactcattgcttcaccagtggcctgcattgtacccactaattgcattggaacttcttgattcaaaatttgctgatcaggaagtaagatccctagctgtgacctggattgaggccattagtgatgatgagctaacagatcttcttccacagtttgtacaagctttgaaatatgaaatttacttgaatagttcattagtgcaattccttttgtccagggcattgggaaatatccagatagcacacaatttatattggcttctcaaagatgccctgcatgatgtacagtttagtacccgatacgaacatgttttgggtgctctcctgtcagtaggaggaaaacgacttagagaagaacttctaaaacagacgaaacttgtacagcttttaggaggagtagcagaaaaagtaaggcaggctagtggatcagccagacaggttgttctccaaagaagtatggaacgagtacagtccttttttcagaaaaataaatgccgtctccctctcaagccaagtctagtggcaaaagaattaaatattaagtcgtgttccttcttcagttctaatgctgtccccctaaaagtcacaatggtgaatgctgaccctatgggagaagaaattaatgtcatgtttaaggttggtgaagatcttcggcaagatatgttagctttacagatgataaagattatggataagatctggcttaaagaaggactagatctgaggatggtaattttcaaatgtctctcaactggcagagatcgaggcatggtggagctggttcctgcttccgataccctcaggaaaatccaagtggaatatggtgtgacaggatcctttaaagataaaccacttgcagagtggctaaggaaatacaatccctctgaagaagaatatgaaaaggcttcagagaactttatctattcctgtgctggatgctgtgtagccacctatgttttaggcatctgtgatcgacacaatgacaatataatgcttcgaagcacgggacacatgtttcacattgactttggaaagtttttgggacatgcacagatgtttggcagcttcaaaagggatcgggctccttttgtgctgacctctgatatggcatatgtcattaatgggggtgaaaagcccaccattcgttttcagttgtttgtggacctctgctgtcaggcctacaacttgataagaaagcagacaaacctttttcttaacctcctttcactgatgattccttcagggttaccagaacttacaagtattcaagatttgaaatacgttagagatgcacttcaaccccaaactacagacgcagaagctacaattttctttactaggcttattgaatcaagtttgggaagcattgccacaaagtttaacttcttcattcacaaccttgctcagcttcgtttttctggtcttccttctaatgatgagcccatcctttcattttcacctaaaacatactcctttagacaagatggtcgaatcaaggaagtctctgtttttacatatcataagaaatacaacccagataaacattatatttatgtagtccgaattttgagggaaggacagattgaaccatcatttgtcttccgaacatttgacgaatttcaggaacttcacaataagctcagtattatttttccactttggaagttaccaggctttcctaataggatggttctaggaagaacacacataaaagatgtagcagccaaaaggaaaattgagttaaacagttacttacagagtttgatgaatgcttcaacggatgtagcagagtgtgatcttgtttgtactttcttccaccctttacttcgtgatgagaaagctgaagggatagctaggtctgcagatgcaggttccttcagtcctactccaggccaaataggaggagctgtgaaattatccatctcttaccgaaatggtactcttttcatcatggtgatgcatatcaaagatcttgttactgaagatggagctgacccaaatccatatgtcaaaacatacctacttccagataaccacaaaacatccaaacgtaaaaccaaaatttcacgaaaaacgaggaatccgacattcaatgaaatgcttgtatacagtggatatagcaaagaaaccctaagacagcgagaacttcaactaagtgtactcagtgcagaatctctgcgggagaattttttcttgggtggagtaaccctgcctttgaaagatttcaacttgagcaaagagacggttaaatggtatcagctgactgcggcaacatacttgtaa
Sequence Length
5061
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
53,742 Da
NCBI Official Full Name
Homo sapiens phosphoinositide-3-kinase, class 2, alpha polypeptide, mRNA
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
NCBI Official Symbol
PIK3C2A
NCBI Official Synonym Symbols
CPK; PI3-K-C2A; PI3K-C2alpha; PI3K-C2-alpha; PI3-K-C2(ALPHA)
NCBI Protein Information
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
UniProt Protein Name
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
UniProt Gene Name
PIK3C2A
UniProt Synonym Gene Names
PI3K-C2-alpha; PtdIns-3-kinase C2 subunit alpha
UniProt Entry Name
P3C2A_HUMAN
NCBI Description
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
Uniprot Description
PIK3C2A: a protein of the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. Its PI3-kinase is not sensitive to nanomolar levels of the inhibitor wortmannin. Activated by insulin and may be involved in integrin-dependent signaling.
Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; Autophagy; EC 2.7.1.154; Kinase, lipid
Chromosomal Location of Human Ortholog: 11p15.5-p14
Cellular Component: cytoplasm; cytosol; membrane; phosphoinositide 3-kinase complex; plasma membrane; vesicle
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity
Biological Process: clathrin cage assembly; endocytosis; epidermal growth factor receptor signaling pathway; exocytosis; insulin receptor signaling pathway; phosphatidylinositol biosynthetic process; platelet-derived growth factor receptor signaling pathway; vascular smooth muscle contraction
Research Articles on PIK3C2A
1. PI3KC2a knockdown results in rerouting of insulin signaling and pancreatic beta cell proliferation.
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Product Notes
The PIK3C2A pik3c2a (Catalog #AAA1273220) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctcaga tatctagcaa cagcggattt aaagaatgtc catcttcaca tccggaacca acaagagcaa aagatgtgga caaagaagaa gcattacaga tggaagcaga ggctttagca aaactgcaaa aggatagaca agtgactgac aatcagagag gctttgagtt gtcaagcagc accagaaaaa aagcacaggt ttataacaag caggattatg atctcatggt gtttcctgaa tcagattccc aaaaaagagc attagatatt gatgtagaaa agctcaccca agctgaactt gagaaactat tgctggatga cagtttcgag actaaaaaaa cacctgtatt accagttact cctattctga gcccttcctt ttcagcacag ctctatttta gacctactat tcagagagga cagtggccac ctggattacc tgggccttcc acttatgctt taccttctat ttatccttct acttacagta aacaggctgc attccaaaat ggcttcaatc caagaatgcc cacttttcca tctacagaac ctatatattt aagtcttccg ggacaatctc catatttctc atatcctttg acacctgcca caccctttca tccacaagga agcttaccta tctatcgtcc agtagtcagt actgacatgg caaaactatt tgacaaaata gctagtacat cagaattttt aaaaaatggg aaagcaagga ctgatttgga gataacagat tcaaaagtca gcaatctaca ggtatctcca aagtctgagg atatcagtaa atttgactgg ttagacttgg atcctctaag taagcctaag gtggataatg tggaggtatt agaccatgag gaagagaaaa atgtttcaag tttgctagca aaggatcctt gggatgctgt tcttcttgaa gagagatcga cagcaaattg tcatcttgaa agaaaggtga atggaaaatc cctttctgtg gcaactgtta caagaagcca gtctttaaat attcgaacaa ctcagcttgc aaaagcccag ggccatatat ctcagaaaga cccaaatggg accagtagtt tgccaactgg aagttctctt cttcaagaag ttgaagtaca gaatgaggag atggcagctt tttgtcgatc cattacaaaa ttgaagacca aatttccata taccaatcac cgcacaaacc caggctattt gttaagtcca gtcacagcgc aaagaaacat atgcggagaa aatgctagtg tgaaggtctc cattgacatt gaaggatttc agctaccagt tacttttacg tgtgatgtga gttctactgt agaaatcatt ataatgcaag ccctttgctg ggtacatgat gacttgaatc aagtagatgt tggcagctat gttctaaaag tttgtggtca agaggaagtg ctgcagaata atcattgcct tggaagtcat gagcatattc aaaactgtcg aaaatgggac acagaaatta gactacaact cttgaccttc agtgcaatgt gtcaaaatct ggcccgaaca gcagaagatg atgaaacacc cgtggattta aacaaacacc tgtatcaaat agaaaaacct tgcaaagaag ccatgacgag acaccctgtt gaagaactct tagattctta tcacaaccaa gtagaactgg ctcttcaaat tgaaaaccaa caccgagcag tagatcaagt aattaaagct gtaagaaaaa tctgtagtgc tttagatggt gtcgagactc ttgccattac agaatcagta aagaagctaa agagagcagt taatcttcca aggagtaaaa ctgctgatgt gacttctttg tttggaggag aagacactag caggagttca actaggggct cacttaatcc tgaaaatcct gttcaagtaa gcataaacca attaactgca gcaatttatg atcttctcag actccatgca aattctggta ggagtcctac agactgtgcc caaagtagca agagtgtcaa ggaagcatgg actacaacag agcagctcca gtttactatt tttgctgctc atggaatttc aagtaattgg gtatcaaatt atgaaaaata ctacttgata tgttcactgt ctcacaatgg aaaggatctt tttaaaccta ttcaatcaaa gaaggttggc acttacaaga atttcttcta tcttattaaa tgggatgaac taatcatttt tcctatccag atatcacaat tgccattaga atcagttctt caccttactc tttttggaat tttaaatcag agcagtggaa gttcccctga ttctaataag cagagaaagg gaccagaagc tttgggcaaa gtttctttac ctctttttga ctttaaacgg tttttaacat gtggaactaa acttctatat ctttggactt catcacatac aaattctgtt cctggaacag ttaccaaaaa aggatatgtc atggaaagaa tagtgctaca ggttgatttt ccttctcctg catttgatat tatttataca actcctcaag ttgacagaag cattatacag caacataact tagaaacact agagaatgat ataaaaggga aacttcttga tattcttcat aaagactcat cacttggact ttctaaagaa gataaagctt ttttatggga gaaacgttat tattgcttca aacacccaaa ttgtcttcct aaaatattag caagcgcccc aaactggaaa tgggttaatc ttgccaaaac ttactcattg cttcaccagt ggcctgcatt gtacccacta attgcattgg aacttcttga ttcaaaattt gctgatcagg aagtaagatc cctagctgtg acctggattg aggccattag tgatgatgag ctaacagatc ttcttccaca gtttgtacaa gctttgaaat atgaaattta cttgaatagt tcattagtgc aattcctttt gtccagggca ttgggaaata tccagatagc acacaattta tattggcttc tcaaagatgc cctgcatgat gtacagttta gtacccgata cgaacatgtt ttgggtgctc tcctgtcagt aggaggaaaa cgacttagag aagaacttct aaaacagacg aaacttgtac agcttttagg aggagtagca gaaaaagtaa ggcaggctag tggatcagcc agacaggttg ttctccaaag aagtatggaa cgagtacagt ccttttttca gaaaaataaa tgccgtctcc ctctcaagcc aagtctagtg gcaaaagaat taaatattaa gtcgtgttcc ttcttcagtt ctaatgctgt ccccctaaaa gtcacaatgg tgaatgctga ccctatggga gaagaaatta atgtcatgtt taaggttggt gaagatcttc ggcaagatat gttagcttta cagatgataa agattatgga taagatctgg cttaaagaag gactagatct gaggatggta attttcaaat gtctctcaac tggcagagat cgaggcatgg tggagctggt tcctgcttcc gataccctca ggaaaatcca agtggaatat ggtgtgacag gatcctttaa agataaacca cttgcagagt ggctaaggaa atacaatccc tctgaagaag aatatgaaaa ggcttcagag aactttatct attcctgtgc tggatgctgt gtagccacct atgttttagg catctgtgat cgacacaatg acaatataat gcttcgaagc acgggacaca tgtttcacat tgactttgga aagtttttgg gacatgcaca gatgtttggc agcttcaaaa gggatcgggc tccttttgtg ctgacctctg atatggcata tgtcattaat gggggtgaaa agcccaccat tcgttttcag ttgtttgtgg acctctgctg tcaggcctac aacttgataa gaaagcagac aaaccttttt cttaacctcc tttcactgat gattccttca gggttaccag aacttacaag tattcaagat ttgaaatacg ttagagatgc acttcaaccc caaactacag acgcagaagc tacaattttc tttactaggc ttattgaatc aagtttggga agcattgcca caaagtttaa cttcttcatt cacaaccttg ctcagcttcg tttttctggt cttccttcta atgatgagcc catcctttca ttttcaccta aaacatactc ctttagacaa gatggtcgaa tcaaggaagt ctctgttttt acatatcata agaaatacaa cccagataaa cattatattt atgtagtccg aattttgagg gaaggacaga ttgaaccatc atttgtcttc cgaacatttg acgaatttca ggaacttcac aataagctca gtattatttt tccactttgg aagttaccag gctttcctaa taggatggtt ctaggaagaa cacacataaa agatgtagca gccaaaagga aaattgagtt aaacagttac ttacagagtt tgatgaatgc ttcaacggat gtagcagagt gtgatcttgt ttgtactttc ttccaccctt tacttcgtga tgagaaagct gaagggatag ctaggtctgc agatgcaggt tccttcagtc ctactccagg ccaaatagga ggagctgtga aattatccat ctcttaccga aatggtactc ttttcatcat ggtgatgcat atcaaagatc ttgttactga agatggagct gacccaaatc catatgtcaa aacataccta cttccagata accacaaaac atccaaacgt aaaaccaaaa tttcacgaaa aacgaggaat ccgacattca atgaaatgct tgtatacagt ggatatagca aagaaaccct aagacagcga gaacttcaac taagtgtact cagtgcagaa tctctgcggg agaatttttt cttgggtgga gtaaccctgc ctttgaaaga tttcaacttg agcaaagaga cggttaaatg gtatcagctg actgcggcaa catacttgta a. It is sometimes possible for the material contained within the vial of "PIK3C2A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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