PHC2 cdna clone
PHC2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PHC2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: nucleoplasm; nucleus; PcG protein complex
Molecular Function: identical protein binding; protein binding
Biological Process: protein sumoylation
Research Articles on PHC2
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Product Notes
The PHC2 phc2 (Catalog #AAA1274776) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgacctcag ggaacggaaa ctctgcctcc agcatcgccg gcactgcccc ccagaatggt gagaataaac caccacaggc cattgtgaaa ccccaaatcc tgacgcatgt tatcgaaggg tttgtgatcc aggagggggc ggagcctttc ccggtgggac gctcgtccct gctggtgggg aatctcaaga agaagtatgc acaggggttc ctgcctgaga aacttccaca gcaggatcac accaccacca ctgactcgga gatggaggag ccctatctgc aagaatccaa agaggagggt gcccccctca aactcaagtg tgagctctgt ggccgggtgg actttgccta taagttcaag cgttccaagc gcttctgttc catggcttgt gcaaagaggt acaacgtggg atgcaccaaa cgggtgggac ttttccactc agaccggagc aagctgcaga aggcaggagc tgcgacccac aaccgccgtc gggccagcaa agccagtctg ccaccactta ccaaggatac caagaagcag ccaacaggca ctgtgcccct ttcggttact gctgctttgc agctaacaca cagccaggaa gactccagcc gttgctcaga taactcaagc tatgaggaac ccttgtcacc catctcagcc agctcatcta cttcccgccg gcgacaaggc cagcgggacc tggagctccc cgacatgcat atgcgggacc tggtgggcat gggacaccac ttcctgccaa gtgagcccac caagtggaat gtagaagacg tctacgaatt catccgctct ctgccaggct gccaggagat agaagaggaa ttccgtgccc aggaaatcga cgggcaagcc ctgctgctgc tcaaggagga ccacctgatg agcgccatga acatcaagct ggggcccgcc ctgaagatct atgcccgcat cagcatgctc aaggactcct ag. It is sometimes possible for the material contained within the vial of "PHC2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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