PFKFB1 cdna clone
PFKFB1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Description
PFKFB1: Synthesis and degradation of fructose 2,6-bisphosphate. Homodimer. Liver. Phosphorylation results in inhibition of the kinase activity.
Protein type: EC 2.7.1.105; Motility/polarity/chemotaxis; Phosphatase (non-protein); Kinase, other; EC 3.1.3.46; Carbohydrate Metabolism - fructose and mannose
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; cytosol
Molecular Function: 6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity; identical protein binding; protein binding
Biological Process: fructose 2,6-bisphosphate metabolic process; gluconeogenesis; glycolysis
Research Articles on PFKFB1
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Product Notes
The PFKFB1 pfkfb1 (Catalog #AAA1265838) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCTCCAG AGATGGGAGA GCTCACCCAA ACCAGGTTGC AGAAGATCTG GATTCCACAC AGCAGCGGCA GCAGCAGGCT GCAACGGAGA AGGGGCTCAT CCATACCCCA GTTTACCAAT TCCCCCACAA TGGTGATCAT GGTGGGTTTA CCAGCTCGAG GCAAGACCTA TATCTCCACA AAGCTCACAC GATATCTCAA CTGGATAGGA ACACCAACTA AAGTGTTTAA TTTAGGCCAG TATCGACGAG AGGCAGTGAG CTACAAGAAC TATGAATTCT TTCTTCCAGA CAACATGGAA GCCCTGCAAA TCAGGAAGCA GTGCGCCCTG GCAGCCCTGA AGGATGTTCA CAACTATCTC AGCCATGAGG AAGGTCATGT TGCGGTTTTT GATGCCACCA ACACTACCAG AGAACGACGG TCACTGATCC TGCAGTTTGC AAAAGAACAT GGTTACAAGG TGTTTTTCAT TGAGTCCATT TGTAATGACC CTGGCATAAT TGCAGAAAAC ATCAGGCAAG TGAAACTTGG CAGCCCTGAT TATATAGACT GTGACCGGGA AAAGGTTCTG GAAGACTTTC TAAAGAGAAT TGAGTGCTAT GAGGTCAACT ACCAACCCTT GGATGAGGAA CTGGACAGCC ACCTGTCCTA CATCAAGATC TTCGACGTGG GCACACGCTA CATGGTGAAC CGAGTGCAGG ATCACATCCA GAGCCGCACA GTCTACTACC TCATGAATAT CCATGTCACA CCTCGCTCCA TCTACCTTTG CCGACATGGC GAGAGTGAAC TCAACATCAG AGGCCGCATC GGAGGTGACT CTGGCCTCTC AGTTCGCGGC AAGCAGTATG CCTATGCCCT GGCCAACTTC ATTCAGTCCC AGGGCATCAG CTCCCTGAAG GTGTGGACCA GTCACATGAA GAGGACCATC CAGACAGCTG AGGCCCTGGG TGTCCCCTAT GAGCAGTGGA AGGCCCTGAA TGAGATTGAT GCGGGTGTCT GTGAGGAGAT GACCTATGAA GAAATCCAGG AACATTACCC TGAAGAATTT GCACTGCGAG ACCAAGATAA ATATCGCTAC CGCTATCCCA AGGGAGAGTC CTATGAGGAT CTGGTTCAGC GTCTGGAGCC AGTGATAATG GAGCTAGAAC GACAGGAGAA TGTACTGGTG ATCTGCCACC AGGCTGTCAT GCGGTGCCTC CTGGCCTATT TCCTGGATAA AAGTTCAGAT GAGCTTCCAT ATCTCAAGTG CCCTCTGCAC ACAGTGCTCA AACTCACTCC TGTGGCTTAT GGCTGCAAAG TGGAATCCAT CTACCTGAAT GTGGAGGCCG TGAACACACA CCGGGAGAAG CCTGAGAATG TGGACATCAC CCGGGAACCT GAGGAAGCCC TGGATACTGT CCCAGCCCAC TACTGA. It is sometimes possible for the material contained within the vial of "PFKFB1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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