PDE3A cdna clone
PDE3A cDNA Clone
Gene Names
PDE3A; HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A
Synonyms
PDE3A; PDE3A cDNA Clone; PDE3A cdna clone
Sequence
atggcagtgcccggcgacgctgcacgagtcagggacaagcccgtccacagtggggtgagtcaagcccccacggcgggccgggactgccaccatcgtgcggaccccgcatcgccgcgggactcgggctgccgtggctgctggggagacctggtgctgcagccgctccggagctctcggaaactttcctccgcgctgtgcgcgggctccctgtcctttctgctggcgctgctggtgaggctggtccgcggggaggtcggctgtgacctggagcagtgtaaggaggcggcggcggcggaggaggaggaagcagccccgggagcagaagggggcgtcttcccggggcctcggggaggtgctcccgggggcggtgcgcggctcagcccctggctgcagccctcggcgctgctcttcagtctcctgtgtgccttcttctggatgggcttgtacctcctgcgcgccggggtgcgcctgcctctggctgtcgcgctgctggccgcctgctgcgggggggaagcgctcgtccagattgggctgggcgtcggggaggatcacttactctcactccccgccgcgggggtggtgctcagctgcttggccgccgcgacatggctggtgctgaggctgaggctgggcgtcctcatgatcgccttgactagcgcggtcaggaccgtgtccctcatttccttagagaggttcaaggtcgcctggagaccttacctggcgtacctggccggcgtgctggggatcctcttggccaggtacgtggaacaaatcttgccgcagtccgcggaggcggctccaagggagcatttggggtcccagctgattgctgggaccaaggaagatatcccggtgtttaagaggaggaggcggtccagctccgtcgtgtccgccgagatgtccggctgcagcagcaagtcccatcggaggacctccctgccctgtataccgagggaacagctcatggggcattcagaatgggaccacaaacgagggccaagaggatcacagtcttcaggaaccagtattactgtggacatcgccgtcatgggcgaggcccacggcctcattaccgacctcctggcagacccttctcttccaccaaacgtgtgcacatccttgagagccgtgagcaacttgctcagcacacagctcaccttccaggccattcacaagcccagagtgaatcccgttacttcgctcagtgaaaactatacctgttctgactctgaagagagctctgaaaaagacaagcttgctattccaaagcgcctgagaaggagtttgcctcctggcttgttgagacgagtttcttccacttggaccaccaccacctcggccacaggtctacccaccttggagcctgcaccagtacggagagaccgcagcaccagcatcaaactgcaggaagcaccttcatccagtcctgattcttggaataatccagtgatgatgaccctcaccaaaagcagatcctttacttcatcctatgctatttctgcagctaaccatgtaaaggctaaaaagcaaagtcgaccaggtgccctcgctaaaatttcacctctttcatcgccctgctcctcacctctccaagggactcctgccagcagcctggtcagcaaaatttctgcagtgcagtttccagaatctgctgacacaactgccaaacaaagcctaggttctcacagggccttaacttacactcagagtgccccagacctatcccctcaaatcctgactccacctgttatatgtagcagctgtggcagaccatattcccaagggaatcctgctgatgagcccctggagagaagtggggtagccactcggacaccaagtagaacagatgacactgctcaagttacctctgattatgaaaccaataacaacagtgacagcagtgacattgtacagaatgaagatgaaacagagtgcctgagagagcctctgaggaaagcatcggcttgcagcacctatgctcctgagaccatgatgtttctggacaaaccaattcttgctcccgaacctcttgtcatggataacctggactcaattatggagcagctaaatacttggaattttccaatttttgatttagtggaaaatataggaagaaaatgtggccgtattcttagtcaggtatcttacagactttttgaagacatgggcctgtttgaagcttttaaaattccaattagggaatttatgaattattttcatgctttggagattggatatagggatattccttatcataacagaatccatgccactgatgttttacatgctgtttggtatcttactacacagcctattccaggcctctcaactgtgattaatgatcatggttcaaccagtgattcagattctgacagtggatttacacatggacatatgggatatgtattctcaaaaacgtataatgtgacagatgataaatacggatgtctgtctgggaatatccctgccttggagttgatggcgctgtatgtggctgcagccatgcacgattatgatcatccaggaaggactaatgctttcctggttgcaactagtgctcctcaggcggtgctatataacgatcgttcagttttggagaatcatcacgcagctgctgcatggaatcttttcatgtcccggccagagtataacttcttaattaaccttgaccatgtggaatttaagcatttccgtttccttgtcattgaagcaattttggccactgacctgaagaaacactttgacttcgtagccaaatttaatggcaaggtaaatgatgatgttggaatagattggaccaatgaaaatgatcgtctactggtttgtcaaatgtgtataaagttggctgatatcaatggtccagctaaatgtaaagaactccatcttcagtggacagatggtattgtcaatgaattttatgaacagggtgatgaagaggccagccttggattacccataagccccttcatggatcgttctgctcctcagctggccaaccttcaggaatccttcatctctcacattgtggggcctctgtgcaactcctatgattcagcaggactaatgcctggaaaatgggtggaagacagcgatgagtcaggagatactgatgacccagaagaagaggaggaagaagcaccagcaccaaatgaagaggaaacctgtgaaaataatgaatctccaaaaaagaagactttcaaaaggagaaaaatctactgccaaataactcagcacctcttacagaaccacaagatgtggaagaaagtcattgaagaggagcaacggttggcaggcatagaaaatcaatccctggaccagacccctcagtcgcactcttcagaacagatccaggctatcaaggaagaagaagaagagaaagggaaaccaagaggcgaggagataccaacccaaaagccagaccagtga
Sequence Length
3426
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
124,979 Da
NCBI Official Full Name
Homo sapiens phosphodiesterase 3A, cGMP-inhibited, mRNA
NCBI Official Synonym Full Names
phosphodiesterase 3A
NCBI Official Symbol
PDE3A
NCBI Official Synonym Symbols
HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A
NCBI Protein Information
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
UniProt Protein Name
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Protein Family
UniProt Gene Name
PDE3A
UniProt Synonym Gene Names
CGI-PDE A
UniProt Entry Name
PDE3A_HUMAN
NCBI Description
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
PDE3A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
Protein type: EC 3.1.4.17; Membrane protein, integral; Nucleotide Metabolism - purine; Membrane protein, multi-pass; Phosphodiesterase
Chromosomal Location of Human Ortholog: 12p12
Cellular Component: cytosol
Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process: cAMP catabolic process; cAMP-mediated signaling; cGMP-mediated signaling; lipid metabolic process; negative regulation of vascular permeability; positive regulation of vascular permeability
Disease: Hypertension And Brachydactyly Syndrome
Research Articles on PDE3A
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Product Notes
The PDE3A pde3a (Catalog #AAA1273376) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcagtgc ccggcgacgc tgcacgagtc agggacaagc ccgtccacag tggggtgagt caagccccca cggcgggccg ggactgccac catcgtgcgg accccgcatc gccgcgggac tcgggctgcc gtggctgctg gggagacctg gtgctgcagc cgctccggag ctctcggaaa ctttcctccg cgctgtgcgc gggctccctg tcctttctgc tggcgctgct ggtgaggctg gtccgcgggg aggtcggctg tgacctggag cagtgtaagg aggcggcggc ggcggaggag gaggaagcag ccccgggagc agaagggggc gtcttcccgg ggcctcgggg aggtgctccc gggggcggtg cgcggctcag cccctggctg cagccctcgg cgctgctctt cagtctcctg tgtgccttct tctggatggg cttgtacctc ctgcgcgccg gggtgcgcct gcctctggct gtcgcgctgc tggccgcctg ctgcgggggg gaagcgctcg tccagattgg gctgggcgtc ggggaggatc acttactctc actccccgcc gcgggggtgg tgctcagctg cttggccgcc gcgacatggc tggtgctgag gctgaggctg ggcgtcctca tgatcgcctt gactagcgcg gtcaggaccg tgtccctcat ttccttagag aggttcaagg tcgcctggag accttacctg gcgtacctgg ccggcgtgct ggggatcctc ttggccaggt acgtggaaca aatcttgccg cagtccgcgg aggcggctcc aagggagcat ttggggtccc agctgattgc tgggaccaag gaagatatcc cggtgtttaa gaggaggagg cggtccagct ccgtcgtgtc cgccgagatg tccggctgca gcagcaagtc ccatcggagg acctccctgc cctgtatacc gagggaacag ctcatggggc attcagaatg ggaccacaaa cgagggccaa gaggatcaca gtcttcagga accagtatta ctgtggacat cgccgtcatg ggcgaggccc acggcctcat taccgacctc ctggcagacc cttctcttcc accaaacgtg tgcacatcct tgagagccgt gagcaacttg ctcagcacac agctcacctt ccaggccatt cacaagccca gagtgaatcc cgttacttcg ctcagtgaaa actatacctg ttctgactct gaagagagct ctgaaaaaga caagcttgct attccaaagc gcctgagaag gagtttgcct cctggcttgt tgagacgagt ttcttccact tggaccacca ccacctcggc cacaggtcta cccaccttgg agcctgcacc agtacggaga gaccgcagca ccagcatcaa actgcaggaa gcaccttcat ccagtcctga ttcttggaat aatccagtga tgatgaccct caccaaaagc agatccttta cttcatccta tgctatttct gcagctaacc atgtaaaggc taaaaagcaa agtcgaccag gtgccctcgc taaaatttca cctctttcat cgccctgctc ctcacctctc caagggactc ctgccagcag cctggtcagc aaaatttctg cagtgcagtt tccagaatct gctgacacaa ctgccaaaca aagcctaggt tctcacaggg ccttaactta cactcagagt gccccagacc tatcccctca aatcctgact ccacctgtta tatgtagcag ctgtggcaga ccatattccc aagggaatcc tgctgatgag cccctggaga gaagtggggt agccactcgg acaccaagta gaacagatga cactgctcaa gttacctctg attatgaaac caataacaac agtgacagca gtgacattgt acagaatgaa gatgaaacag agtgcctgag agagcctctg aggaaagcat cggcttgcag cacctatgct cctgagacca tgatgtttct ggacaaacca attcttgctc ccgaacctct tgtcatggat aacctggact caattatgga gcagctaaat acttggaatt ttccaatttt tgatttagtg gaaaatatag gaagaaaatg tggccgtatt cttagtcagg tatcttacag actttttgaa gacatgggcc tgtttgaagc ttttaaaatt ccaattaggg aatttatgaa ttattttcat gctttggaga ttggatatag ggatattcct tatcataaca gaatccatgc cactgatgtt ttacatgctg tttggtatct tactacacag cctattccag gcctctcaac tgtgattaat gatcatggtt caaccagtga ttcagattct gacagtggat ttacacatgg acatatggga tatgtattct caaaaacgta taatgtgaca gatgataaat acggatgtct gtctgggaat atccctgcct tggagttgat ggcgctgtat gtggctgcag ccatgcacga ttatgatcat ccaggaagga ctaatgcttt cctggttgca actagtgctc ctcaggcggt gctatataac gatcgttcag ttttggagaa tcatcacgca gctgctgcat ggaatctttt catgtcccgg ccagagtata acttcttaat taaccttgac catgtggaat ttaagcattt ccgtttcctt gtcattgaag caattttggc cactgacctg aagaaacact ttgacttcgt agccaaattt aatggcaagg taaatgatga tgttggaata gattggacca atgaaaatga tcgtctactg gtttgtcaaa tgtgtataaa gttggctgat atcaatggtc cagctaaatg taaagaactc catcttcagt ggacagatgg tattgtcaat gaattttatg aacagggtga tgaagaggcc agccttggat tacccataag ccccttcatg gatcgttctg ctcctcagct ggccaacctt caggaatcct tcatctctca cattgtgggg cctctgtgca actcctatga ttcagcagga ctaatgcctg gaaaatgggt ggaagacagc gatgagtcag gagatactga tgacccagaa gaagaggagg aagaagcacc agcaccaaat gaagaggaaa cctgtgaaaa taatgaatct ccaaaaaaga agactttcaa aaggagaaaa atctactgcc aaataactca gcacctctta cagaaccaca agatgtggaa gaaagtcatt gaagaggagc aacggttggc aggcatagaa aatcaatccc tggaccagac ccctcagtcg cactcttcag aacagatcca ggctatcaag gaagaagaag aagagaaagg gaaaccaaga ggcgaggaga taccaaccca aaagccagac cagtga. It is sometimes possible for the material contained within the vial of "PDE3A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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