PCGF1 cdna clone
PCGF1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]
Uniprot Description
PCGF1: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: nucleus; PcG protein complex
Molecular Function: protein binding; protein C-terminus binding
Biological Process: regulation of transcription, DNA-dependent
Research Articles on PCGF1
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Product Notes
The PCGF1 pcgf1 (Catalog #AAA1271836) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaggcttc ggaaccagct ccagtcagtg tacaagatgg acccgctacg gaacgaggag gaggttcgag tgaagatcaa agacttgaat gaacacattg tttgctgcct atgcgccggc tacttcgtgg atgccaccac catcacagag tgtcttcata ctttctgcaa gagttgtatt gtgaagtacc tccaaactag caagtactgc cccatgtgca acattaagat ccacgagaca cagccactgc tcaacctcaa actggaccgg gtcatgcagg acatcgtgta taagctggtg cctggcttgc aagacagtga agagaaacgg attcgggaat tctaccagtc ccgaggtttg gaccgggtca cccagcccac tggggaagag ccagcactga gcaacctcgg cctccccttc agcagctttg accactctaa agcccactac tatcgctatg atgagcagtt gaacctgtgc ctggagcggc tgagttctgg caaagacaag aataaaagcg tcctgcagaa caagtatgtc cgatgttctg ttagagctga ggtacgccat ctccggaggg tcctgtgtca ccgcttgatg ctaaaccctc agcatgtgca gctccttttt gacaatgaag ttctccctga tcacatgaca atgaagcaga tatggctctc ccgctggttc ggcaagccat cccctttgct tttacaatac agtgtgaaag agaagaggag gtag. It is sometimes possible for the material contained within the vial of "PCGF1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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