OXSR1 cdna clone
OXSR1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Uniprot Description
OSR1: oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB.
Protein type: Protein kinase, STE; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; STE group; STE20 family; FRAY subfamily
Chromosomal Location of Human Ortholog: 3p22.2
Cellular Component: cytoplasm
Molecular Function: ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: peptidyl-threonine phosphorylation; protein amino acid phosphorylation
Research Articles on OXSR1
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Product Notes
The OXSR1 oxsr1 (Catalog #AAA1269139) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtccgagg actcgagcgc cctgccctgg tccatcaaca gggacgatta cgagctgcag gaggtgatcg ggagtggagc aactgctgta gtccaagcag cttattgtgc ccctaaaaag gagaaagtgg caatcaaacg gataaacctt gagaaatgtc aaactagcat ggatgaactc ctgaaagaaa ttcaagccat gagtcaatgc catcatccta atattgtatc ttactacaca tcttttgtgg taaaagatga gctgtggctt gtcatgaagc tgctaagtgg aggttctgtt ctggatatta ttaagcacat tgtggcaaaa ggggaacaca aaagtggagt cctagatgaa tctaccattg ctacgatact ccgagaagta ctggaagggc tggaatatct gcataaaaat ggacagatcc acagagatgt gaaagctgga aacattcttc ttggagaaga tggctcagta cagattgcag actttggggt tagtgctttt ttagcaactg gtggtgatat tacccgaaat aaagtgagaa agacctttgt tggcacccct tgttggatgg cacctgaagt tatggaacag gtccgtggtt atgatttcaa agctgatatt tggagttttg gaattacagc aattgaattg gctacagggg cggctcctta tcataaatat ccaccaatga aggttttaat gctgacactg cagaacgatc ctccttcttt ggaaactggt gttcaagata aagaaatgct gaaaaaatat ggaaaatcat ttagaaaaat gatttcattg tgccttcaaa aagatccaga aaaaagacca acagcagcag aactattaag gcacaaattt ttccagaaag caaagaataa agaatttctt caagaaaaaa cattgcagag agcaccaacc atttctgaaa gagcaaaaaa ggttcggaga gtaccaggtt ccagtgggcg tcttcataag acagaggatg gaggctggga gtggagtgat gatgaatttg atgaagaaag tgaggaaggg aaagcagcaa tttcacaact caggtctccc cgagtgaaag aatcaatatc aaattctgag ctctttccaa caactgatcc tgtgggtact ttgctccaag ttccagaaca gatctctgct catctacctc agccagctgg gcagattgct acacagccaa ctcaagtctc tctcccaccc accgcagagc cagcaaaaac agctcaggct ttgtcttcag gatcaggttc acaagaaacc aagatcccaa tcagtctagt actaagatta aggaattcca aaaaagaact aaatgatatt cgatttgaat ttactcctgg gagagataca gcagagggtg tctctcagga actcatttct gctggcctgg tcgacggaag ggatttagta atagtggcag ctaatttgca gaaaattgtg gaagaacctc agtcaaatcg atctgtcact ttcaaactgg catctggtgt cgaaggctca gatattcctg atgatggtaa actgatagga tttgcccagc tcagcatcag ctaa. It is sometimes possible for the material contained within the vial of "OXSR1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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