NPR3 cdna clone
NPR3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Description
ANP-C: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Belongs to the ANF receptor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5p13.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: adenylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled
Biological Process: cAMP biosynthetic process; cAMP-mediated signaling; cyclic nucleotide biosynthetic process; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of nitric-oxide synthase activity; regulation of blood pressure; regulation of osteoblast proliferation; skeletal development
Research Articles on NPR3
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Product Notes
The NPR3 npr3 (Catalog #AAA1272108) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCCGTCTC TGCTGGTGCT CACTTTCTCC CCGTGCGTAC TACTCGGCTG GGCGTTGCTG GCCGGCGGCA CCGGTGGCGG TGGCGTTGGC GGCGGCGGCG GTGGCGCGGG CATAGGCGGC GGACGCCAGG AGAGAGAGGC GCTGCCGCCA CAGAAGATCG AGGTGCTGGT GTTACTGCCC CAGGATGACT CGTACTTGTT TTCACTCACC CGGGTGCGGC CGGCCATCGA GTATGCTCTG CGCAGCGTGG AGGGCAACGG GACTGGGAGG CGGCTTCTGC CGCCGGGCAC TCGCTTCCAG GTGGCTTACG AGGATTCAGA CTGTGGGAAC CGTGCGCTCT TCAGCTTGGT GGACCGCGTG GCGGCGGCGC GGGGCGCCAA GCCAGACCTT ATCCTGGGGC CAGTGTGCGA GTATGCAGCA GCGCCAGTGG CCCGGCTTGC ATCGCACTGG GACCTGCCCA TGCTGTCGGC TGGGGCGCTG GCCGCTGGCT TCCAGCACAA GGACTCTGAG TACTCGCACC TCACGCGCGT GGCGCCCGCC TACGCCAAGA TGGGCGAGAT GATGCTCGCC CTGTTCCGCC ACCACCACTG GAGCCGCGCT GCACTGGTCT ACAGCGACGA CAAGCTGGAG CGGAACTGCT ACTTCACCCT CGAGGGGGTC CACGAGGTCT TCCAGGAGGA GGGTTTGCAC ACGTCCATCT ACAGTTTCGA CGAGACCAAA GACTTGGATC TGGAAGACAT CGTGCGCAAT ATCCAGGCCA GTGAGAGAGT GGTGATCATG TGTGCGAGCA GTGACACCAT CCGGAGCATC ATGCTGGTGG CGCACAGGCA TGGCATGACC AGTGGAGACT ACGCCTTCTT CAACATTGAG CTCTTCAACA GCTCTTCCTA TGGAGATGGC TCATGGAAGA GAGGAGACAA ACACGACTTT GAAGCTAAGC AAGCATACTC GTCCCTCCAG ACAGTCACTC TACTGAGGAC AGTGAAACCT GAGTTTGAGA AGTTTTCCAT GGAGGTGAAA AGTTCAGTTG AGAAACAAGG GCTCAATATG GAGGATTACG TTAACATGTT TGTTGAAGGA TTCCACGATG CCATCCTCCT CTACGTCTTG GCTCTACATG AAGTACTCAG AGCTGGTTAC AGCAAAAAGG ATGGAGGGAA AATTATACAG CAGACTTGGA ACAGAACATT TGAAGGTATC GCCGGGCAGG TGTCCATAGA TGCCAACGGA GACCGATATG GGGATTTCTC TGTGATTGCC ATGACTGATG TGGAGGCGGG CACCCAGGAG GTTATTGGTG ATTATTTTGG AAAAGAAGGT CGTTTTGAAA TGCGGCCGAA TGTCAAATAT CCTTGGGGCC CTTTAAAACT GAGAATAGAT GAAAACCGAA TTGTAGAGCA TACAAACAGC TCTCCCTGCA AATCATCAGG TGGCCTAGAA GAATCGGCAG TGACAGGAAT TGTCGTGGGG GCTTTACTAG GAGCTGGCTT GCTAATGGCC TTCTACTTTT TCAGGAAGAA ATACAGAATA ACCATTGAGA GGCGAACCCA GCAAGAAGAA AGTAACCTTG GAAAACATCG GGAATTACGG GAAGATTCCA TCAGATCCCA TTTTTCAGTA GCTTAA. It is sometimes possible for the material contained within the vial of "NPR3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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