NLRC4 cdna clone
NLRC4 cDNA Clone
Gene Names
NLRC4; CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1
Synonyms
NLRC4; NLRC4 cDNA Clone; NLRC4 cdna clone
Sequence
atgaatttcataaaggacaatagccgagcccttattcaaagaatgggaatgactgttataaagcaaatcacagatgacctatttgtatggaatgttctgaatcgcgaagaagtaaacatcatttgctgcgagaaggtggagcaggatgctgctagagggatcattcacatgattttgaaaaagggttcagagtcctgtaacctctttcttaaatcccttaaggagtggaactatcctctatttcaggacttgaatggacaaagtctttttcatcagacatcagaaggagacttggacgatttggctcaggatttaaaggacttgtaccataccccatcttttctgaacttttatccccttggtgaagatattgacattatttttaacttgaaaagcaccttcacagaacctgtcctgtggaggaaggaccaacaccatcaccgcgtggagcagctgaccctgaatggcctcctgcaggctcttcagagcccctgcatcattgaaggggaatctggcaaaggcaagtccactctgctgcagcgaattgccatgctctggggctccggaaagtgcaaggctctgaccaagttcaaattcgtcttcttcctccgtctcagcagggcccagggtggactttttgaaaccctctgtgatcaactcctggatatacctggcacaatcaggaagcagacattcatggccatgctgctgaagctgcggcagagggttcttttccttcttgatggctacaatgaattcaagccccagaactgcccagaaatcgaagccctgataaaggaaaaccaccgcttcaagaacatggtcatcgtcaccactaccactgagtgcctgaggcacatacggcagtttggtgccctgactgctgaggtgggggatatgacagaagacagcgcccaggctctcatccgagaagtgctgatcaaggagcttgctgaaggcttgttgctccaaattcagaaatccaggtgcttgaggaatctcatgaagacccctctctttgtggtcatcacttgtgcaatccagatgggtgaaagtgagttccactctcacacacaaacaacgctgttccataccttctatgatctgttgatacagaaaaacaaacacaaacataaaggtgtggctgcaagtgacttcattcggagcctggaccactgtggagacctagctctggagggtgtgttctcccacaagtttgatttcgaactgcaggatgtgtccagcgtgaatgaggatgtcctgctgacaactgggctcctctgtaaatatacagctcaaaggttcaagccaaagtataaattctttcacaagtcattccaggagtacacagcaggacgaagactcagcagtttattgacgtctcatgagccagaggaggtgaccaaggggaatggttacttgcagaaaatggtttccatttcggacattacatccacttatagcagcctgctccggtacacctgtgggtcatctgtggaagccaccagggctgttatgaagcacctcgcagcagtgtatcaacacggctgccttctcggactttccatcgccaagaggcctctctggagacaggaatctttgcaaagtgtgaaaaacaccactgagcaagaaattctgaaagccataaacatcaattcctttgtagagtgtggcatccatttatatcaagagagtacatccaaatcagccctgagccaagaatttgaagctttctttcaaggtaaaagcttatatatcaactcagggaacatccccgattacttatttgacttctttgaacatttgcccaattgtgcaagtgccctggacttcattaaactggacttttatgggggagctatggcttcatgggaaaaggctgcagaagacacaggtggaatccacatggaagaggccccagaaacctacattcccagcagggctgtatctttgttcttcaactggaagcaggaattcaggactctggaggtcacactccgggatttcagcaagttgaataagcaagatatcagatatctggggaaaatattcagctctgccacaagcctcaggctgcaaataaagagatgtgctggtgtggctggaagcctcagtttggtcctcagcacctgtaagaacatttattctctcatggtggaagccagtcccctcaccatagaagatgagaggcacatcacatctgtaacaaacctgaaaaccttgagtattcatgacctacagaatcaacggctgccgggtggtctgactgacagcttgggtaacttgaagaaccttacaaagctcataatggataacataaagatgaatgaagaagatgctataaaactagctgaaggcctgaaaaacctgaagaagatgtgtttatttcatttgacccacttgtctgacattggagagggaatggattacatagtcaagtctctgtcaagtgaaccctgtgaccttgaagaaattcaattagtctcctgctgcttgtctgcaaatgcagtgaaaatcctagctcagaatcttcacaatttggtcaaactgagcattcttgatttatcagaaaattacctggaaaaagatggaaatgaagctcttcatgaactgatcgacaggatgaacgtgctagaacagctcaccgcactgatgctgccctggggctgtgacgtgcaaggcagcctgagcagcctgttgaaacatttggaggaggtcccacaactcgtcaagcttgggttgaaaaactggagactcacagatacagagattagaattttaggtgcattttttggaaagaaccctctgaaaaacttccagcagttgaatttggcgggaaatcgtgtgagcagtgatggatggcttgccttcatgggtgtatttgagaatcttaagcaattagtgttttttgactttagtactaaagaatttctacctgatccagcattagtcagaaaacttagccaagtgttatccaagttaacttttctgcaagaagctaggcttgttgggtggcaatttgatgatgatgatctcagtgttattacaggtgcttttaaactagtaactgcttaa
Sequence Length
3075
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
10,646 Da
NCBI Official Full Name
Homo sapiens NLR family, CARD domain containing 4, mRNA
NCBI Official Synonym Full Names
NLR family CARD domain containing 4
NCBI Official Symbol
NLRC4
NCBI Official Synonym Symbols
CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1
NCBI Protein Information
NLR family CARD domain-containing protein 4
UniProt Protein Name
NLR family CARD domain-containing protein 4
Protein Family
UniProt Gene Name
NLRC4
UniProt Synonym Gene Names
CARD12; CLAN; CLAN1; IPAF; Clan protein; Ipaf
UniProt Entry Name
NLRC4_HUMAN
NCBI Description
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Description
NLRC4: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: cytosol; nucleus; spindle microtubule
Molecular Function: ATP binding; cysteine protease inhibitor activity; identical protein binding; magnesium ion binding; protein binding; protein homodimerization activity; ubiquitin-protein ligase activity
Biological Process: activation of innate immune response; activation of NF-kappaB transcription factor; caspase activation; defense response to bacterium; detection of bacterium; inflammatory response; innate immune response; interleukin-1 beta secretion; positive regulation of apoptosis; protein homooligomerization; regulation of apoptosis; regulation of signal transduction
Disease: Autoinflammation With Infantile Enterocolitis; Familial Cold Autoinflammatory Syndrome 4
Research Articles on NLRC4
Similar Products
Product Notes
The NLRC4 nlrc4 (Catalog #AAA1269526) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaatttca taaaggacaa tagccgagcc cttattcaaa gaatgggaat gactgttata aagcaaatca cagatgacct atttgtatgg aatgttctga atcgcgaaga agtaaacatc atttgctgcg agaaggtgga gcaggatgct gctagaggga tcattcacat gattttgaaa aagggttcag agtcctgtaa cctctttctt aaatccctta aggagtggaa ctatcctcta tttcaggact tgaatggaca aagtcttttt catcagacat cagaaggaga cttggacgat ttggctcagg atttaaagga cttgtaccat accccatctt ttctgaactt ttatcccctt ggtgaagata ttgacattat ttttaacttg aaaagcacct tcacagaacc tgtcctgtgg aggaaggacc aacaccatca ccgcgtggag cagctgaccc tgaatggcct cctgcaggct cttcagagcc cctgcatcat tgaaggggaa tctggcaaag gcaagtccac tctgctgcag cgaattgcca tgctctgggg ctccggaaag tgcaaggctc tgaccaagtt caaattcgtc ttcttcctcc gtctcagcag ggcccagggt ggactttttg aaaccctctg tgatcaactc ctggatatac ctggcacaat caggaagcag acattcatgg ccatgctgct gaagctgcgg cagagggttc ttttccttct tgatggctac aatgaattca agccccagaa ctgcccagaa atcgaagccc tgataaagga aaaccaccgc ttcaagaaca tggtcatcgt caccactacc actgagtgcc tgaggcacat acggcagttt ggtgccctga ctgctgaggt gggggatatg acagaagaca gcgcccaggc tctcatccga gaagtgctga tcaaggagct tgctgaaggc ttgttgctcc aaattcagaa atccaggtgc ttgaggaatc tcatgaagac ccctctcttt gtggtcatca cttgtgcaat ccagatgggt gaaagtgagt tccactctca cacacaaaca acgctgttcc ataccttcta tgatctgttg atacagaaaa acaaacacaa acataaaggt gtggctgcaa gtgacttcat tcggagcctg gaccactgtg gagacctagc tctggagggt gtgttctccc acaagtttga tttcgaactg caggatgtgt ccagcgtgaa tgaggatgtc ctgctgacaa ctgggctcct ctgtaaatat acagctcaaa ggttcaagcc aaagtataaa ttctttcaca agtcattcca ggagtacaca gcaggacgaa gactcagcag tttattgacg tctcatgagc cagaggaggt gaccaagggg aatggttact tgcagaaaat ggtttccatt tcggacatta catccactta tagcagcctg ctccggtaca cctgtgggtc atctgtggaa gccaccaggg ctgttatgaa gcacctcgca gcagtgtatc aacacggctg ccttctcgga ctttccatcg ccaagaggcc tctctggaga caggaatctt tgcaaagtgt gaaaaacacc actgagcaag aaattctgaa agccataaac atcaattcct ttgtagagtg tggcatccat ttatatcaag agagtacatc caaatcagcc ctgagccaag aatttgaagc tttctttcaa ggtaaaagct tatatatcaa ctcagggaac atccccgatt acttatttga cttctttgaa catttgccca attgtgcaag tgccctggac ttcattaaac tggactttta tgggggagct atggcttcat gggaaaaggc tgcagaagac acaggtggaa tccacatgga agaggcccca gaaacctaca ttcccagcag ggctgtatct ttgttcttca actggaagca ggaattcagg actctggagg tcacactccg ggatttcagc aagttgaata agcaagatat cagatatctg gggaaaatat tcagctctgc cacaagcctc aggctgcaaa taaagagatg tgctggtgtg gctggaagcc tcagtttggt cctcagcacc tgtaagaaca tttattctct catggtggaa gccagtcccc tcaccataga agatgagagg cacatcacat ctgtaacaaa cctgaaaacc ttgagtattc atgacctaca gaatcaacgg ctgccgggtg gtctgactga cagcttgggt aacttgaaga accttacaaa gctcataatg gataacataa agatgaatga agaagatgct ataaaactag ctgaaggcct gaaaaacctg aagaagatgt gtttatttca tttgacccac ttgtctgaca ttggagaggg aatggattac atagtcaagt ctctgtcaag tgaaccctgt gaccttgaag aaattcaatt agtctcctgc tgcttgtctg caaatgcagt gaaaatccta gctcagaatc ttcacaattt ggtcaaactg agcattcttg atttatcaga aaattacctg gaaaaagatg gaaatgaagc tcttcatgaa ctgatcgaca ggatgaacgt gctagaacag ctcaccgcac tgatgctgcc ctggggctgt gacgtgcaag gcagcctgag cagcctgttg aaacatttgg aggaggtccc acaactcgtc aagcttgggt tgaaaaactg gagactcaca gatacagaga ttagaatttt aggtgcattt tttggaaaga accctctgaa aaacttccag cagttgaatt tggcgggaaa tcgtgtgagc agtgatggat ggcttgcctt catgggtgta tttgagaatc ttaagcaatt agtgtttttt gactttagta ctaaagaatt tctacctgat ccagcattag tcagaaaact tagccaagtg ttatccaagt taacttttct gcaagaagct aggcttgttg ggtggcaatt tgatgatgat gatctcagtg ttattacagg tgcttttaaa ctagtaactg cttaa. It is sometimes possible for the material contained within the vial of "NLRC4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
