NFYA cdna clone
NFYA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
NFYA: stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. Involved in cisplatin resistance. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: CCAAT-binding factor complex; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding
Biological Process: positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
Research Articles on NFYA
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Product Notes
The NFYA nfya (Catalog #AAA1271980) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagcagt atacagcaaa cagcaatagt tcgacagagc agattgttgt ccaggcagga cagattcagc agcaggtcca agggcagcca ttaatggtgc aggtcagtgg aggccagcta atcacatcaa ctggccaacc catcatggtc caggctgtcc ctggtgggca aggtcaaacc atcatgcaag tacctgtttc tggaacacag ggtttgcagc aaatacagtt ggtcccacct ggacagatcc agatccaggg tggacaggct gtgcaggtgc agggccagca gggccagacc cagcagatca tcatccagca gccccagacg gctgtcactg ctggccagac tcagacacag cagcagattg ctgtccaggg acagcaagtg gcacagactg ctgaagggca gaccatcgtc tatcaaccag ttaatgcaga tggcaccatt ctccagcaag ttacagtccc tgtttcaggc atgatcacta tcccagcagc cagtttggca ggagcacaga ttgttcaaac aggagccaat accaacacaa ccagcagtgg gcaagggact gtcactgtga cactaccagt ggcaggcaat gtggtcaatt caggagggat ggtcatgatg gttcctgggg ctggctctgt gcctgctatc caaagaatcc ctctacctgg agcagagatg cttgaagaag agcctctcta cgtgaatgcc aaacaataca accgtattct taagaggagg caagcccgag ctaaactaga ggcagaaggg aaaattccaa aggagagaag gaaatacctg catgagtctc ggcaccgtca tgccatggca cggaagcgtg gtgaaggtgg acgatttttc tctccaaagg aaaaggatag tccccatatg caggatccaa accaagccga tgaagaagca atgacacaga tcatccgagt gtcctaa. It is sometimes possible for the material contained within the vial of "NFYA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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