NELF cdna clone
NELF cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Description
NSMF: Couples NMDA receptor signaling to the nucleus. Influences outgrowth of olfactory axons and migration of LHRH neurons. Defects in NELF may be associated with idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cortical cytoskeleton; cytoplasm; dendrite; membrane; neuron projection; nuclear envelope; nuclear matrix; nuclear membrane; nucleoplasm; nucleus; perikaryon; postsynaptic density; synapse
Molecular Function: calcium-dependent protein binding
Biological Process: positive regulation of protein amino acid dephosphorylation; regulation of dendrite morphogenesis; regulation of neuron apoptosis; regulation of neuronal synaptic plasticity
Disease: Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
Research Articles on NELF
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Product Notes
The NELF nsmf (Catalog #AAA1276301) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGGCGCCG CCGCCTCCAG GAGGAGGGCG CTGAGGAGCG AGGCCATGTC CTCGGTGGCG GCCAAAGTGC GAGCAGCCCG AGCGTTTGGA GAGTACCTGT CCCAGAGTCA CCCTGAGAAC CGCAACGGCG CAGATCACCT GCTGGCTGAT GCCTACTCTG GCCACGACGG GTCCCCCGAG ATGCAGCCGG CCCCCCAGAA CAAGCGCCGC CTGTCCCTCG TCTCCAACGG CTGCTACGAG GGCAGCCTCT CAGAGGAGCC CAGCATTAGG AAGCCCGCAG GCGAGGGCCC TCAGCCTCGA GTGTACACCA TCTCTGGGGA GCCTGCCCTG CTGCCCAGCC CTGAGGCGGA GGCCATTGAG CTGGCGGTGG TGAAGGGGCG GCGGCAGCGG CACCCTCACC ATCACAGCCA GCCCCTGCGC GCCAGCCCTG GTGGCAGCCG GGAGGACGTC AGCAGGCCCT GCCAGAGCTG GGCGGGCAGC CGCCAGGGCT CCAAGGAGTG CCCCGGATGT GCCCAGCTGG CTCCTGGCCC CACCCCTCGG GCCTTTGGGC TGGACCAGCC ACCTCTGCCT GAGACCTCCG GTCGCCGCAA GAAGCTGGAG AGGATGTACA GCGTTGACCG TGTGTCTGAC GACATCCCTA TTCGTACCTG GTTCCCCAAG GAAAATCTTT TCAGCTTCCA GACAGCAACC ACAACTATGC AAGCGAACTT CCGCAAACAC CTGCGCATGG TCGGCAGCCG GAGGGTGAAG GCCCAGACGT TCGCTGAGCG GCGCGAGCGG AGCTTCAGCC GGTCCTGGAG CGACCCCACC CCCATGAAAG CCGACACTTC CCACGACTCC CGAGACAGCA GTGACCTGCA GAGCTCCCAC TGCACGCTGG ACGAGGCCTT CGAGGACCTG GACTGGGACA CTGAGAAGGG CCTGGAGGCT GTGGCCTGCG ACACCGAAGG CTTCGTGCCA CCAAAGGTCA TGCTCATTTC CTCCAAGGTG CCCAAGGCTG AGTACATCCC CACTATCATC CGCCGGGATG ACCCCTCCAT CATCCCCATC CTCTACGACC ATGAGCACGC AACCTTCGAG GACATCCTTG AGGAGATAGA GAGGAAGCTG AACGTCTACC ACAAGGGAGC CAAGATCTGG AAAATGCTGA TTTTCTGCCA GGGAGGTCCT GGACACCTCT ATCTCCTCAA GAACAAGGTG GCCACCTTTG CCAAAGTGGA GAAGGAAGAG GACATGATTC ACTTCTGGAA GCGGCTGAGC CGCCTGATGA GCAAAGTGAA CCCAGAGCCG AACGTCATCC ACATCATGGG CTGCTACATT CTGGGGAACC CCAATGGAGA GAAGCTGTTC CAGAACCTCA GGACCCTCAT GACTCCTTAT AGGGTCACCT TCGAGTCACC CCTGGAGCTC TCAGCCCAAG GGAAGCAGAT GATCGAGACG TACTTTGACT TCCGGTTGTA TCGCCTGTGG AAGAGCCGCC AGCACTCGAA GCTGCTGGAC TTTGACGACG TCCTGTGA. It is sometimes possible for the material contained within the vial of "NELF, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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