NCF4 cdna clone
NCF4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Description
p40phox: a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cytosol; endosome membrane; membrane; NADPH oxidase complex
Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding; protein dimerization activity; superoxide-generating NADPH oxidase activator activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; immune response; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type Iii
Research Articles on NCF4
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Product Notes
The NCF4 ncf4 (Catalog #AAA1272360) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctgtgg cccagcagct gcgggccgag agtgactttg aacagcttcc ggatgatgtt gccatctcgg ccaacattgc tgacatcgag gagaagagag gcttcaccag ccactttgtt ttcgtcatcg aggtgaagac aaaaggagga tccaagtacc tcatctaccg ccgctaccgc cagttccatg ctttgcagag caagctggag gagcgcttcg ggccagacag caagagcagt gccctggcct gtaccctgcc cacactccca gccaaagtct acgtgggtgt gaaacaggag atcgccgaga tgcggatacc tgccctcaac gcctacatga agagcctgct cagcctgccg gtctgggtgc tgatggatga ggacgtccgg atcttctttt accagtcgcc ctatgactca gagcaggtgc cccaggcact ccgccggctc cgcccgcgca cccggaaagt caagagcgtg tccccacagg gcaacagcgt tgaccgcatg gcagctccga gagcagaggc tctatttgac ttcactggaa acagcaaact ggagctgaat ttcaaagctg gagatgtgat cttcctcctc agtcggatca acaaagactg gctggagggc actgtccggg gagccacggg catcttccct ctctccttcg tgaagatcct caaagacttc cctgaggagg acgaccccac caactggctg cgttgctact actacgaaga caccatcagc accatcaagt ctgtggcctg ggagggaggg gcctgtccag ccttcctgcc atccctacga ccaccgcccc tcacatcacc ttctcatggg tccctctccc actccaaagc ccccagtggc tcccagatga gccacaatgc tgtaacaagc catcaacgtc cagggtggcc tggccagcct cattcccctt tcccccaccc cacaccccac ttccagcctg atgcctcctt actccagcct gtcaccccct tagggacatc gcggtggagg aagatctcag cagcactccc ctattga. It is sometimes possible for the material contained within the vial of "NCF4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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