MYO5B cdna clone
MYO5B cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
Uniprot Description
MYO5B: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Defects in MYO5B are a cause of diarrhea type 2 (DIAR2). DIAR2 is characterized by onset of intractable life- threatening watery diarrhea during infancy. Two forms are recognized: early-onset MVID with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.
Protein type: Motor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q21
Cellular Component: apical cortex; cytoplasmic vesicle membrane; protein complex; recycling endosome
Molecular Function: microfilament motor activity; protein binding; Rab GTPase binding
Biological Process: endosome localization; renal water homeostasis; vesicle-mediated transport
Disease: Diarrhea 2, With Microvillus Atrophy
Research Articles on MYO5B
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Product Notes
The MYO5B myo5b (Catalog #AAA1275436) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAAGAAAG CCCAGGACCT AGAAGCTGCC CAGGCATTGG CCCAGAGTGA GAGGAAGCGC CATGAGCTCA ACAGGCAGGT CACGGTCCAG CGGAAAGAGA AGGATTTCCA GGGCATGCTG GAGTACCACA AAGAGGACGA GGCCCTCCTC ATCCGGAACC TGGTGACAGA CTTGAAGCCC CAGATGCTGT CGGGCACAGT GCCCTGTCTC CCCGCCTACA TCCTCTACAT GTGCATCCGG CACGCGGACT ACACCAACGA CGATCTCAAG GTGCACTCCC TGCTGACCTC CACCATCAAC GGCATTAAGA AAGTCCTGAA AAAGCACAAT GATGACTTTG AGATGACGTC ATTCTGGTTA TCCAACACCT GCCGCCTTCT TCACTGTCTG AAGCAGTACA GCGGGGATGA GGGCTTCATG ACTCAGAACA CTGCAAAGCA GAATGAACAC TGTCTTAAGA ATTTTGACCT CACCGAATAC CGTCAGGTGC TGAGTGACCT TTCCATTCAG ATCTACCAGC AGCTCATTAA AATTGCCGAG GGCGTGTTAC AGCCGATGAT AGTTTCTGCC ATGTTGGAAA ATGAGAGCAT TCAGGGTCTA TCTGGTGTGA AGCCCACCGG CTACCGGAAG CGCTCCTCCA GCATGGCAGA TGGGGATAAC TCATACTGCC TGGAAGCTAT CATCCGCCAG ATGAATGCCT TTCATACAGT CATGTGTGAC CAGGGCTTGG ACCCTGAGAT CATCCTGCAG GTATTCAAAC AGCTCTTCTA CATGATCAAC GCAGTGACTC TTAACAACCT GCTCTTGCGG AAGGACGTCT GCTCTTGGAG CACAGGCATG CAACTCAGGT ACAATATAAG TCAGCTTGAG GAGTGGCTTC GGGGAAGAAA CCTTCACCAG AGTGGAGCAG TTCAGACCAT GGAACCTCTG ATCCAAGCAG CCCAGCTCCT GCAATTAAAG AAGAAAACCC AGGAGGACGC AGAGGCTATC TGCTCCCTGT GTACCTCCCT CAGCACCCAG CAGATTGTCA AAATTTTAAA CCTTTATACT CCCCTGAATG AATTTGAAGA ACGGGTAACA GTGGCCTTTA TACGAACAAT CCAGGCACAA CTACAAGAGC GGAATGACCC TCAGCAACTG CTATTAGATG CCAAGCACAT GTTTCCTGTT TTGTTTCCAT TTAATCCATC TTCTCTAACC ATGGACTCAA TCCACATCCC AGCGTGTCTC AATCTGGAAT TCCTCAATGA AGTCTGA. It is sometimes possible for the material contained within the vial of "MYO5B, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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