MUSK cdna clone
MUSK cDNA Clone
Gene Names
MUSK; CMS9; FADS
Synonyms
MUSK; MUSK cDNA Clone; MUSK cdna clone
Sequence
ATGAGAGAGCTCGTCAACATTCCACTGGTACATATTCTTACTCTGGTTGCCTTCAGCGGAACTGAGAAACTTCCAAAAGCTCCTGTCATCACCACTCCTCTTGAAACAGTGGATGCCTTAGTTGAAGAAGTGGCTACTTTCATGTGTGCAGTGGAATCCTACCCCCAGCCTGAGATTTCCTGGACTAGAAATAAAATTCTCATTAAACTCTTTGACACCCGGTACAGCATCCGGGAGAATGGGCAGCTCCTCACCATCCTGAGTGTGGAAGACAGTGATGATGGCATTTACTGCTGCACGGCCAACAATGGTGTGGGAGGAGCTGTGGAGAGTTGTGGAGCCCTGCAAGTGAAGATGAAACCTAAAATAACTCGTCCTCCCATAAATGTGAAAATAATAGAAGGATTAAAAGCAGTCCTACCATGTACTACAATGGGTAATCCCAAACCATCAGTGTCTTGGATAAAGGGAGACAGCCCTCTCAGGGAAAATTCCCGAATTGCAGTTCTTGAATCTGGGAGCTTGAGGATTCATAACGTACAAAAGGAAGATGCAGGACAGTATCGATGTGTGGCAAAAAACAGCCTCGGGACAGCATATTCCAAAGTGGTGAAGCTGGAAGTTGAGGAAGAAAGTGAACCCGAACAAGATACTAAAGTTTTTGCCAGGATCCTGCGGGCTCCTGAATCCCACAATGTCACCTTTGGCTCCTTTGTGACCCTGCACTGTACAGCAACAGGCATTCCTGTCCCCACCATCACCTGGATTGAAAACGGAAATGCTGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATTGACTCAAGACTGCAGCTGTTTATCACCAAGCCAGGACTCTACACATGCATAGCTACCAATAAGCATGGGGAGAAGTTCAGTACTGCCAAGGCTGCAGCCACCATCAGCATAGCAGAATGGAGAGAGTACTGCTTGGCAGTAAAGGAGCTCTTCTGCGCAAAAGAATGGCTGGTAATGGAAGAGAAGACCCACAGAGGACTCTACAGATCCGAGATGCATTTGCTGTCCGTGCCAGAATGCAGCAAGCTTCCCAGCATGCATTGGGACCCCACGGCCTGTGCCAGACTGCCACATCTAGCATTCCCACCAATGACGTCCTCAAAGCCAAGTGTGGACATTCCAAATCTGCCTTCCTCCTCCTCTTCTTCCTTCTCTGTCTCACCTACATACTCCATGACTGTAATAATCTCCATCATGTCCAGCTTTGCAATATTTGTGCTTCTTACCATAACTACTCTCTATTGCTGCCGAAGAAGAAAACAATGGAAAAATAAGAAAAGAGAATCAGCAGCAGTAACCCTCACCACACTGCCTTCTGAGCTCTTACTAGATAGACTTCATCCCAACCCCATGTACCAGAGGATGCCGCTCCTTCTGAACCCCAAATTGCTCAGCCTGGAGTATCCAAGGAATAACATTGAATATGTGAGAGACATCGGAGAGGGAGCGTTTGGAAGGGTGTTTCAAGCAAGGGCACCAGGCTTACTTCCCTATGAACCTTTCACTATGGTGGCAGTAAAGATGCTCAAAGAAGAAGCCTCGGCAGATATGCAAGCGGACTTTCAGAGGGAGGCAGCCCTCATGGCAGAATTTGACAACCCTAACATTGTGAAGCTATTAGGAGTGTGTGCTGTCGGGAAGCCAATGTGCCTGCTCTTTGAATACATGGCCTATGGTGACCTCAATGAGTTCCTCCGCAGCATGTCCCCTCACACCGTGTGCAGCCTCAGTCACAGTGACTTGTCTATGAGGGCTCAGGTCTCCAGCCCTGGGCCCCCACCCCTCTCCTGTGCTGAGCAGCTTTGCATTGCCAGGCAGGTGGCAGCTGGCATGGCTTACCTCTCAGAACGTAAGTTTGTTCACCGAGATTTAGCCACCAGGAACTGCCTGGTGGGCGAGAACATGGTGGTGAAAATTGCCGACTTTGGCCTCTCCAGGAACATCTACTCAGCAGACTACTACAAAGCTAATGAAAACGACGCTATCCCTATCCGTTGGATGCCACCAGAGTCCATTTTTTATAACCGCTACACTACAGAGTCTGATGTGTGGGCCTATGGCGTGGTCCTCTGGGAGATCTTCTCCTATGGCCTGCAGCCCTACTATGGGATGGCCCATGAGGAGGTCATTTACTACGTGCGAGATGGCAACATCCTCTCCTGCCCTGAGAACTGCCCCGTGGAGCTGTACAATCTCATGCGTCTATGTTGGAGCAAGCTGCCTGCAGACAGACCCAGTTTCACCAGTATTCACCGAATTCTGGAACGCATGTGTGAGAGGGCAGAGGGAACTGTGAGTGTCTAA
Sequence Length
2352
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
86,425 Da
NCBI Official Full Name
Homo sapiens muscle, skeletal, receptor tyrosine kinase, mRNA
NCBI Official Synonym Full Names
muscle associated receptor tyrosine kinase
NCBI Official Symbol
MUSK
NCBI Official Synonym Symbols
CMS9; FADS
NCBI Protein Information
muscle, skeletal receptor tyrosine-protein kinase
UniProt Protein Name
Muscle, skeletal receptor tyrosine-protein kinase
Protein Family
UniProt Gene Name
MUSK
UniProt Synonym Gene Names
MuSK; Muscle-specific kinase receptor
UniProt Entry Name
MUSK_HUMAN
NCBI Description
This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
Uniprot Description
MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity.
Protein type: EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; TK group; Musk family
Chromosomal Location of Human Ortholog: 9q31.3-q32
Cellular Component: integral to plasma membrane; neuromuscular junction; postsynaptic membrane; receptor complex
Molecular Function: protein binding; protein-tyrosine kinase activity
Biological Process: memory; neuromuscular junction development; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; regulation of synaptic growth at neuromuscular junction; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Fetal Akinesia Deformation Sequence; Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency
Research Articles on MUSK
Similar Products
Product Notes
The MUSK musk (Catalog #AAA1277324) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGAGAGC TCGTCAACAT TCCACTGGTA CATATTCTTA CTCTGGTTGC CTTCAGCGGA ACTGAGAAAC TTCCAAAAGC TCCTGTCATC ACCACTCCTC TTGAAACAGT GGATGCCTTA GTTGAAGAAG TGGCTACTTT CATGTGTGCA GTGGAATCCT ACCCCCAGCC TGAGATTTCC TGGACTAGAA ATAAAATTCT CATTAAACTC TTTGACACCC GGTACAGCAT CCGGGAGAAT GGGCAGCTCC TCACCATCCT GAGTGTGGAA GACAGTGATG ATGGCATTTA CTGCTGCACG GCCAACAATG GTGTGGGAGG AGCTGTGGAG AGTTGTGGAG CCCTGCAAGT GAAGATGAAA CCTAAAATAA CTCGTCCTCC CATAAATGTG AAAATAATAG AAGGATTAAA AGCAGTCCTA CCATGTACTA CAATGGGTAA TCCCAAACCA TCAGTGTCTT GGATAAAGGG AGACAGCCCT CTCAGGGAAA ATTCCCGAAT TGCAGTTCTT GAATCTGGGA GCTTGAGGAT TCATAACGTA CAAAAGGAAG ATGCAGGACA GTATCGATGT GTGGCAAAAA ACAGCCTCGG GACAGCATAT TCCAAAGTGG TGAAGCTGGA AGTTGAGGAA GAAAGTGAAC CCGAACAAGA TACTAAAGTT TTTGCCAGGA TCCTGCGGGC TCCTGAATCC CACAATGTCA CCTTTGGCTC CTTTGTGACC CTGCACTGTA CAGCAACAGG CATTCCTGTC CCCACCATCA CCTGGATTGA AAACGGAAAT GCTGTTTCTT CTGGGTCCAT TCAAGAGAGT GTGAAAGACC GAGTGATTGA CTCAAGACTG CAGCTGTTTA TCACCAAGCC AGGACTCTAC ACATGCATAG CTACCAATAA GCATGGGGAG AAGTTCAGTA CTGCCAAGGC TGCAGCCACC ATCAGCATAG CAGAATGGAG AGAGTACTGC TTGGCAGTAA AGGAGCTCTT CTGCGCAAAA GAATGGCTGG TAATGGAAGA GAAGACCCAC AGAGGACTCT ACAGATCCGA GATGCATTTG CTGTCCGTGC CAGAATGCAG CAAGCTTCCC AGCATGCATT GGGACCCCAC GGCCTGTGCC AGACTGCCAC ATCTAGCATT CCCACCAATG ACGTCCTCAA AGCCAAGTGT GGACATTCCA AATCTGCCTT CCTCCTCCTC TTCTTCCTTC TCTGTCTCAC CTACATACTC CATGACTGTA ATAATCTCCA TCATGTCCAG CTTTGCAATA TTTGTGCTTC TTACCATAAC TACTCTCTAT TGCTGCCGAA GAAGAAAACA ATGGAAAAAT AAGAAAAGAG AATCAGCAGC AGTAACCCTC ACCACACTGC CTTCTGAGCT CTTACTAGAT AGACTTCATC CCAACCCCAT GTACCAGAGG ATGCCGCTCC TTCTGAACCC CAAATTGCTC AGCCTGGAGT ATCCAAGGAA TAACATTGAA TATGTGAGAG ACATCGGAGA GGGAGCGTTT GGAAGGGTGT TTCAAGCAAG GGCACCAGGC TTACTTCCCT ATGAACCTTT CACTATGGTG GCAGTAAAGA TGCTCAAAGA AGAAGCCTCG GCAGATATGC AAGCGGACTT TCAGAGGGAG GCAGCCCTCA TGGCAGAATT TGACAACCCT AACATTGTGA AGCTATTAGG AGTGTGTGCT GTCGGGAAGC CAATGTGCCT GCTCTTTGAA TACATGGCCT ATGGTGACCT CAATGAGTTC CTCCGCAGCA TGTCCCCTCA CACCGTGTGC AGCCTCAGTC ACAGTGACTT GTCTATGAGG GCTCAGGTCT CCAGCCCTGG GCCCCCACCC CTCTCCTGTG CTGAGCAGCT TTGCATTGCC AGGCAGGTGG CAGCTGGCAT GGCTTACCTC TCAGAACGTA AGTTTGTTCA CCGAGATTTA GCCACCAGGA ACTGCCTGGT GGGCGAGAAC ATGGTGGTGA AAATTGCCGA CTTTGGCCTC TCCAGGAACA TCTACTCAGC AGACTACTAC AAAGCTAATG AAAACGACGC TATCCCTATC CGTTGGATGC CACCAGAGTC CATTTTTTAT AACCGCTACA CTACAGAGTC TGATGTGTGG GCCTATGGCG TGGTCCTCTG GGAGATCTTC TCCTATGGCC TGCAGCCCTA CTATGGGATG GCCCATGAGG AGGTCATTTA CTACGTGCGA GATGGCAACA TCCTCTCCTG CCCTGAGAAC TGCCCCGTGG AGCTGTACAA TCTCATGCGT CTATGTTGGA GCAAGCTGCC TGCAGACAGA CCCAGTTTCA CCAGTATTCA CCGAATTCTG GAACGCATGT GTGAGAGGGC AGAGGGAACT GTGAGTGTCT AA. It is sometimes possible for the material contained within the vial of "MUSK, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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