MTHFD1 cdna clone
MTHFD1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]
Uniprot Description
MTHFD1: an ubiquitous trifunctional enzyme containing two major domains: a N-terminal part, containing methylene-THF dehydrogenase and methenyl-THF cyclohydrolase activities, and a C-terminal part containing a formyl-THF synthetase domain.
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3; Hydrolase; Ligase; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 14q24
Cellular Component: cytoplasm; cytosol; membrane
Molecular Function: formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; methylenetetrahydrofolate dehydrogenase activity; protein binding
Biological Process: 10-formyltetrahydrofolate biosynthetic process; embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; folic acid metabolic process; heart development; methionine biosynthetic process; methionine metabolic process; neural tube closure; one-carbon compound metabolic process; purine base biosynthetic process; purine nucleotide biosynthetic process; serine family amino acid biosynthetic process; serine family amino acid metabolic process
Disease: Neural Tube Defects, Folate-sensitive
Research Articles on MTHFD1
Similar Products
Product Notes
The MTHFD1 mthfd1 (Catalog #AAA1272926) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcgccag cagaaatcct gaacgggaag gagatctccg cgcaaataag ggcgagactg aaaaatcaag tcactcagtt gaaggagcaa gtacctggtt tcacaccacg cctggcaata ttacaggttg gcaacagaga tgattccaat ctttatataa atgtgaagct gaaggctgct gaagagattg ggatcaaagc cactcacatt aagttaccaa gaacaaccac agaatctgag gtgatgaagt acattacatc tttgaatgaa gactctactg tacatgggtt cttagtgcag ctacctttag attcagagaa ttccattaac actgaagaag tgatcaatgc tattgcaccc gagaaggatg tggatggatt gactagcatc aatgctggga gacttgctag aggtgacctc aatgactgtt tcattccttg tacgcctaag ggatgcttgg aactcatcaa agagacaggg gtgccgattg ccggaaggca tgctgtggtg gttgggcgca gtaaaatagt tggggccccg atgcatgact tgcttctgtg gaacaatgcc acagtgacca cctgccactc caagactgcc catctggatg aggaggtaaa taaaggtgac atcctggtgg ttgcaactgg tcagcctgaa atggttaaag gggagtggat caaacctggg gcaatagtca tcgactgtgg aatcaattat gtcccagatg ataaaaaacc aaatgggaga aaagttgtgg gtgatgtggc atacgacgag gccaaagaga gggcgagctt catcactcct gttcctggcg gcgtagggcc catgacagtt gcaatgctca tgcagagcac agtagagagt gccaagcgtt tcctggagaa atttaagcca ggaaagtgga tgattcagta taacaacctt aacctcaaga cacctgttcc aagtgacatt gatatatcac gatcttgtaa accgaagccc attggtaagc tggctcgaga aattggtctg ctgtctgaag aggtagaatt atatggtgaa acaaaggcca aagttctgct gtcagcacta gaacgcctga agcaccggcc tgatgggaaa tacgtggtgg tgactggaat aactccaaca cccctgggag aagggaaaag cacaactaca atcgggctag tgcaagccct tggtgcccat ctctaccaga atgtctttgc gtgtgtgcga cagccttctc agggccccac ctttggaata aaaggtggcg ctgcaggagg cggctactcc caggtcattc ctatggaaga gtttaatctc cacctcacag gtgacatcca tgccatcact gcagctaata acctcgttgc tgcggccatt gatgctcgga tatttcatga actgacccag acagacaagg ctctctttaa tcgtttggtg ccatcagtaa atggagtgag aaggttctct gacatccaaa tccgaaggtt aaagagacta ggcattgaaa agactgaccc taccacactg acagatgaag agataaacag atttgcaaga ttggacattg atccagaaac cataacttgg caaagagtgt tggataccaa tgatagattc ctgaggaaga tcacgattgg acaggctcca acggagaagg gtcacacacg gacggcccag tttgatatct ctgtggccag tgaaattatg gctgtcctgg ctctcaccac ttctctagaa gacatgagag agagactggg caaaatggtg gtggcatcca gtaagaaagg agagcccgtc agtgccgaag atctgggggt gagtggtgca ctgacagtgc ttatgaagga cgcaatcaag cccaatctca tgcagacact ggagggcact ccagtgtttg tccatgctgg cccgtttgcc aacatcgcac atggcaattc ctccatcatt gcagaccaga tcgcactcaa gcttgttggc ccagaagggt ttgtagtgac ggaagcagga tttggagcag acattggaat ggaaaagttt tttaacatca aatgccggta ttccggcctc tgcccccacg tggtggtgct tgttgccact gtcagggctc tcaagatgca cgggggcggc cccacggtca ctgctggact gcctcttccc aaggcttaca tacaggagaa cctggagctg gttgaaaaag gcttcagtaa cttgaagaaa caaattgaaa atgccagaat gtttggaatt ccagtagtag tggccgtgaa tgcattcaag acggatacag agtctgagct ggacctcatc agccgccttt ccagagaaca tggggctttt gatgccgtga agtgcactca ctgggcagaa gggggcaagg gtgccttagc cctggctcag gccgtccaga gagcagcaca agcacccagc agcttccagc tcctttatga cctcaagctc ccagttgagg ataaaatcag gatcattgca cagaagatct atggagcaga tgacattgaa ttacttcccg aagctcaaca caaagctgaa gtctacacga agcagggctt tgggaatctc cccatctgca tggctaaaac acacttgtct ttgtctcaca acccagagca aaaaggtgtc cctacaggct tcattctgcc cattcgcgac atccgcgcca gcgttggggc tggttttctg taccccttag taggaacgat gagcacaatg cctggactcc ccacccggcc ctgtttttat gatattgatt tggaccctga aacagaacag gtgaatggat tattctaa. It is sometimes possible for the material contained within the vial of "MTHFD1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
