MSL3 cdna clone
MSL3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
Uniprot Description
MSL3L1: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: Xp22.3
Cellular Component: NuA4 histone acetyltransferase complex; nucleoplasm
Molecular Function: DNA binding; methylated histone residue binding
Biological Process: chromatin remodeling; chromatin silencing; histone deacetylation
Research Articles on MSL3
Similar Products
Product Notes
The MSL3 msl3 (Catalog #AAA1266814) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgagcgcga gcgagggcat gaaatttaaa ttccactcag gggagaaagt gctgtgcttc gagcctgacc ccaccaaggc gcgagtgctg tacgatgcca agattgttga tgttattgtt gggaaagacg aaaaaggcag aaagatccca gaatatctga tccattttaa tggttggaac agaagctggg atagatgggc agcagaagat catgtgcttc gtgataccga tgaaaatcgt agattacagc gtaaattggc aagaaaagct gtagctcgcc tgaggagcac aggaagaaag aagaagcgct gcaggttgcc tggtgtggac tctgtcttaa aaggcctccc cactgaagaa aaagatgaaa atgatgaaaa ctcattaagc agttcctctg actgtagtga aaacaaggat gaagaaataa gtgaagaaag tgatattgaa gaaaagactg aagtgaaaga agaaccagag cttcaaacaa gaagggaaat ggaagaaaga acaataacta tagaaatccc tgaagttctg aagaagcagc tggaggatga ttgttactac attaacagga ggaaacggtt agtgaaactt ccatgccaga ccaacatcat aacgattttg gaatcctatg tgaagcattt tgctatcaat gcagcctttt cagccaatga gaggcctcgt caccatcacg ttatgccaca tgccaacatg aacgtgcatt atatcccagc agaaaagaat gttgaccttt gtaaggagat ggtggatgga ttaagaataa cctttgatta cactctcccg ttggttttac tctatccata tgaacaagct cagtataaaa aggtgacttc gtctaaattt tttcttccaa ttaaggaaag tgccacaagc actaacagga gccaggagga actctctccc agtccgcctt tgttgaatcc atccacgcca cagtccacag agagtcagcc gaccaccggt gaaccagcca cccccaaaag gcgcaaagct gagccagaag cattgcagtc tctgaggcgg tccacgcgcc acagtgccaa ctgtgacagg ctttctgaga gcagcgcttc acctcagccc aagcgccggc agcaggacac atccgccagc atgcccaagc tcttcctgca cctggaaaag aagacacctg tgcatagcag atcatcttca cctattcctc tgactcctag caaggaaggg agtgctgtgt ttgctggctt tgaagggaga agaactaatg aaataaacga ggtcctctcc tggaagcttg tgcctgacaa ttacccccca ggtgaccagc cgcctccacc ctcttacatt tatggggcac aacatttgct gcgattgttt gtgaaacttc cagaaatcct tggaaagatg tccttttctg agaagaatct gaaggcttta ttgaagcact ttgatctctt tttgaggttt ttagcagaat accacgatga cttcttccca gagtcggctt atgtcgctgc ctgtgaggca cattacagca ccaagaaccc ccgggcaatt tattaa. It is sometimes possible for the material contained within the vial of "MSL3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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