MSC cdna clone

MSC

Cat. Num. AAA200568

• Synonyms: MSC; ABF-1; ABF1; bHLHa22; MYOR; MSC cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGTCCACGG GCTCGGTGAG TGATCCGGAG GAGATGGAGC TTCGGGGGCT GCAGCGGGAG TACCCGGTCC CCGCCTCCAA GAGGCCGCCC CTCCGCGGCG TAGAGCGCAG CTACGCCTCG CCCAGTGACA ACTCGTCGGC AGAGGAGGAG GACCCCGACG GCGAGGAGGA GCGCTGCGCT CTGGGCACAG CCGGCAGCGC GGAAGGCTGC AAGAGGAAGC GGCCCCGTGT GGCTGGGGGC GGCGGCGCAG GTGGTAGCGC GGGCGGTGGT GGCAAGAAGC CCCTCCCGGC CAAGGGCTCA GCCGCAGAGT GCAAGCAGTC GCAGCGGAAC GCGGCCAACG CCCGTGAGCG TGCCCGGATG CGCGTGCTGA GCAAAGCCTT CTCCAGGCTC AAGACCAGCC TGCCCTGGGT GCCCCCCGAC ACTAAGCTCT CCAAGCTGGA CACGCTCCGG CTGGCTTCCA GTTACATCGC TCACCTGCGG CAGCTGTTGC AGGAGGACCG CTATGAGAAC GGCTACGTGC ACCCAGTGAA CCTGACATGG CCATTCGTGG TCTCGGGAAG ACCGGACTCT GACACCAAAG AAGTTTCCGC AGCCAACAGA CTATGTGGAA CCACCGCTTA A; ; Translation Sequence: MSTGSVSDPE EMELRGLQRE YPVPASKRPP LRGVERSYAS PSDNSSAEEE DPDGEEERCA LGTAGSAEGC KRKRPRVAGG GGAGGSAGGG GKKPLPAKGS AAECKQSQRN AANARERARM RVLSKAFSRL KTSLPWVPPD TKLSKLDTLR LASSYIAHLR QLLQEDRYEN GYVHPVNLTW PFVVSGRPDS DTKEVSAANR LCGTTA
• Sequence Length: 206

• Species: Human
• Chromosome Location: 8q21
• OMIM Reference Number: 603628
• cDNA Size: 621bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for MSC cdna clone

This gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.

Product Categories/Family for MSC cdna clone

Epigenetics and Nuclear Signaling; Cardiovascular; Metabolism; Tags & Cell Markers

NCBI and Uniprot Product Information

• NCBI GI #: 116805332
• NCBI Accession #: NP_005089.2
• NCBI GenBank Nucleotide #: NM_005098.3
• UniProt Accession #: O60682
• NCBI Official Full Name: musculin
• UniProt Protein Name: Musculin
• Protein Family: Musculin
• UniProt Gene Name: MSC
• UniProt Synonym Gene Names: ABF1; BHLHA22; ABF-1; bHLHa22
• UniProt Entry Name: MUSC_HUMAN

Uniprot Description

MSC: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: nucleus

Molecular Function: protein dimerization activity; transcription corepressor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; branchiomeric skeletal muscle development; negative regulation of transcription from RNA polymerase II promoter; palate development