MLX cdna clone

MLX

Cat. Num. AAA201011

• Gene Names: MLX; TF4; MAD7; MXD7; TCFL4; bHLHd13
• Synonyms: MLX; bHLHd13; MAD7; MXD7; TCFL4; MLX cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGACGGAGCCGGGCGCCTCTCCCGAGGACCCTTGGGTCAAGGTGGAGTATGCCTACAGCGACAACAGCCTGGACCCCGGGCTTTTTGTAGAAAGCACCCGCAAGGGGAGTGTAGTGTCCAGAGCTAATAGCATCGGTTCCACCAGTGCCTCTTCTGTCCCCAACACAGATGATGAGGACAGTGATTACCACCAGGAGGCCTACAAGGAGTCCTACAAAGACCGGCGGCGGCGCGCACACACTCAGGCTGAGCAGAAGAGGAGGGACGCCATCAAGAGAGGCTATGATGACCTTCAGACCATCGTCCCCACTTGCCAGCAGCAGGACTTCTCCATTGGCTCCCAAAAGCTCAGCAAAGCCATCGTTCTACAAAAGACCATTGACTACATTCAGTTTTTGCACAAGGAGAAGAAAAAGCAGGAGGAGGAGGTGTCCACGTTACGCAAGGATGTCACCGCCCTAAAGATCATGAAAGTGAACTATGAGCAGATTGTGAAGGCACACCAGGACAACCCCCATGAAGGGGAGGACCAGGTCTCTGACCAGGTCAAGTTCAACGTGTTTCAAGGCATCATGGATTCCCTGTTCCAGTCCTTCAATGCCTCCATCTCAGTGGCCAGCTTCCAGGAGCTGTCAGCGTGTGTCTTCAGCTGGATCGAGGAGCACTGTAAGCCTCAGACCCTGCGGGAGATTGTGATTGGCGTCCTGCACCAATTGAAAAACCAGCTTTACTGA; ; Translation Sequence: MTEPGASPED PWVKVEYAYS DNSLDPGLFV ESTRKGSVVS RANSIGSTSA SSVPNTDDEDSDYHQEAYKE SYKDRRRRAH TQAEQKRRDA IKRGYDDLQT IVPTCQQQDF SIGSQKLSKAIVLQKTIDYI QFLHKEKKKQ EEEVSTLRKD VTALKIMKVN YEQIVKAHQD NPHEGEDQVSDQVKFNVFQG IMDSLFQSFN ASISVASFQE LSACVFSWIE EHCKPQTLRE IVIGVLHQLKNQLY
• Sequence Length: 244

• Species: Human
• Chromosome Location: 17q21.1
• OMIM Reference Number: 602976
• cDNA Size: 735bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for MLX cdna clone

MLX belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Product Categories/Family for MLX cdna clone

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 38201612
• NCBI GeneID: 6945
• NCBI Accession #: NP_937847.1
• NCBI GenBank Nucleotide #: NM_198204.1
• UniProt Accession #: Q9UH92
• NCBI Official Full Name: max-like protein X isoform beta
• NCBI Official Synonym Full Names: MAX dimerization protein MLX
• NCBI Official Symbol: MLX
• NCBI Official Synonym Symbols: TF4; MAD7; MXD7; TCFL4; bHLHd13
• NCBI Protein Information: max-like protein X
• UniProt Protein Name: Max-like protein X
• Protein Family: Max-like protein
• UniProt Gene Name: MLX
• UniProt Synonym Gene Names: BHLHD13; TCFL4; bHLHd13
• UniProt Entry Name: MLX_HUMAN

NCBI Description

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

MLX: Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; transcription factor activity; transcription factor binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; energy reserve metabolic process; positive regulation of cellular metabolic process; nucleocytoplasmic transport; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent