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METTL11A cdna clone

METTL11A cDNA Clone

Gene Names
NTMT1; NRMT; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A
Synonyms
METTL11A; METTL11A cDNA Clone; METTL11A cdna clone
Ordering
For Research Use Only!
Sequence
atgacgagcgaggtgatagaagacgagaagcaattctattccaaggccaagacctactggaaacaaatcccacccacggtggacggcatgcttggggggtatggccacatctccagcatcgacatcaacagctcccggaagtttctgcagaggtttttgagggaaggcccgaacaagacaggaacgtcctgtgccctggactgtggagctggcattgggaggatcaccaagcggctgctcctgccgctgttcagagaggtggatatggtcgacataacggaggacttcctggttcaagccaagacctacctgggggaggagggcaagagggtgaggaactacttctgttgtgggctccaggacttcaccccggagccggactcttacgacgtgatctggatccagtgggtgataggccacctcaccgatcagcacctggccgagttcctgcggcgctgcaagggcagcctccgccccaacggcatcatcgtcatcaaagacaacatggcccaggagggcgtgattctggacgacgtggacagcagcgtgtgccgggaccttgacgtggtccgcaggatcatctgcagtgcaggcctcagcctcctggccgaggagaggcaggagaacctccccgatgagatctaccatgtctatagctttgccctgagatga
Sequence Length
672
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
15,896 Da
NCBI Official Full Name
Homo sapiens methyltransferase like 11A, mRNA
NCBI Official Synonym Full Names
N-terminal Xaa-Pro-Lys N-methyltransferase 1
NCBI Official Symbol
NTMT1
NCBI Official Synonym Symbols
NRMT; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A
NCBI Protein Information
N-terminal Xaa-Pro-Lys N-methyltransferase 1
UniProt Protein Name
N-terminal Xaa-Pro-Lys N-methyltransferase 1
UniProt Gene Name
NTMT1
UniProt Synonym Gene Names
C9orf32; METTL11A; NRMT; NRMT1; NTM1A
UniProt Entry Name
NTM1A_HUMAN

NCBI Description

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

Uniprot Description

METTL11A: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. Belongs to the methyltransferase superfamily. NTM1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase, protein N-term; EC 2.1.1.244; Methyltransferase

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein methyltransferase activity

Biological Process: chromosome segregation; N-terminal peptidyl-alanine methylation; N-terminal peptidyl-proline di-methylation; spindle organization and biogenesis

Research Articles on METTL11A

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Product Notes

The METTL11A ntmt1 (Catalog #AAA1278982) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgacgagcg aggtgataga agacgagaag caattctatt ccaaggccaa gacctactgg aaacaaatcc cacccacggt ggacggcatg cttggggggt atggccacat ctccagcatc gacatcaaca gctcccggaa gtttctgcag aggtttttga gggaaggccc gaacaagaca ggaacgtcct gtgccctgga ctgtggagct ggcattggga ggatcaccaa gcggctgctc ctgccgctgt tcagagaggt ggatatggtc gacataacgg aggacttcct ggttcaagcc aagacctacc tgggggagga gggcaagagg gtgaggaact acttctgttg tgggctccag gacttcaccc cggagccgga ctcttacgac gtgatctgga tccagtgggt gataggccac ctcaccgatc agcacctggc cgagttcctg cggcgctgca agggcagcct ccgccccaac ggcatcatcg tcatcaaaga caacatggcc caggagggcg tgattctgga cgacgtggac agcagcgtgt gccgggacct tgacgtggtc cgcaggatca tctgcagtgc aggcctcagc ctcctggccg aggagaggca ggagaacctc cccgatgaga tctaccatgt ctatagcttt gccctgagat ga. It is sometimes possible for the material contained within the vial of "METTL11A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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