MAP2K5 cdna clone
MAP2K5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Uniprot Description
MEK5: a dual specificity protein kinase of the STE7 family. Activates ERK5 and is itself phosphorylated and activated by MEKK3, as well as by atypical protein kinase C isoforms. Involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced isoforms have been described.
Protein type: Kinase, protein; Protein kinase, STE; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 15q23
Cellular Component: cytoplasm
Molecular Function: protein binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; inhibition of NF-kappaB transcription factor; negative regulation of caspase activity; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-8 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Research Articles on MAP2K5
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Product Notes
The MAP2K5 map2k5 (Catalog #AAA1277937) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgctgtggc tagcccttgg cccctttcct gccatggaga accaggtgct ggtaattcgc atcaagatcc caaatagtgg cgcggtggac tggacagtgc actccgggcc gcagttactc ttcagggatg tgctggatgt gataggccag gttctgcctg aagcaacaac tacagcattt gaatatgaag atgaagatgg tgatcgaatt acagtgagaa gtgatgagga aatgaaggca atgctgtcat attattattc cacagtaatg gaacagcaag taaatggaca gttaatagag cctctgcaga tatttccaag agcctgcaag cctcctgggg aacggaacat acatggcctg aaggtgaata ctcgggccgg accctctcaa cacagcagcc cagcagtctc agattcactt ccaagcaata gcttaaagaa gtcttctgct gaactgaaaa aaatactagc caatggccag atgaatgaac aagacatacg atatcgggac actcttggtc atggcaacgg aggcacagtc tacaaagcat atcatgtccc gagtgggaaa atattagctg taaaggtcat actactagat attacactgg aacttcagaa gcaaattatg tctgaattgg aaattcttta taagtgcgat tcatcatata tcattggatt ttatggagca ttttttgtag aaaacaggat ttcaatatgt acagaattca tggatggggg atctttggat gtatatagga aaatgccaga acatgtcctt ggaagaattg cagtagcagt tgttaaaggc cttacttatt tgtggagttt aaagatttta catagagacg tgaagccctc caatatgcta gtaaacacaa gaggacaggt taagctgtgt gattttggag ttagcactca gctggtgaat tctatagcca agacgtatgt tggaacaaat gcttatatgg cgcctgaaag gatttcaggg gagcagtatg gaattcattc tgatgtctgg agcttaggaa tctcttttat ggagcttgct cttgggaggt ttccatatcc tcagattcag aaaaaccagg gatctttaat gcctctccag cttctgcagt gcattgttga tgaggattcg cccgtccttc cagttggaga gttctcggag ccatttgtac atttcatcac tcagtgtatg cgaaaacagc caaaagaaag gccagcacct gaagaattga tgggccaccc gttcatcgtg cagttcaatg atggaaatgc cgccgtggtg tccatgtggg tgtgccgggc gctggaggag aggcggagcc agcaggggcc cccgtga. It is sometimes possible for the material contained within the vial of "MAP2K5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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