MAGEA6 cdna clone
MAGEA6 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Description
MAGE-A6: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.
Protein type: Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: Xq28
Molecular Function: protein binding
Research Articles on MAGEA6
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Product Notes
The MAGEA6 magea6 (Catalog #AAA1270694) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcctcttg agcagaggag tcagcactgc aagcctgaag aaggccttga ggcccgagga gaggccctgg gcctggtggg tgcgcaggct cctgctactg aggagcagga ggctgcctcc tcctcttcta ctctagttga agtcaccctg ggggaggtgc ctgctgccga gtcaccagat cctccccaga gtcctcaggg agcctccagc ctccccacta ccatgaacta ccctctctgg agccaatcct atgaggactc cagcaaccaa gaagaggagg ggccaagcac cttccctgac ctggagtctg agttccaagc agcactcagt aggaaggtgg ccaagttggt tcattttctg ctcctcaagt atcgagccag ggagccggtc acaaaggcag aaatgctggg gagtgtcgtc ggaaattggc agtacttctt tcctgtgatc ttcagcaaag cttccgattc cttgcagctg gtctttggca tcgagctgat ggaagtggac cccatcggcc acgtgtacat ctttgccacc tgcctgggcc tctcctacga tggcctgctg ggtgacaatc agatcatgcc caagacaggc ttcctgataa tcatcctggc cataatcgca aaagagggcg actgtgcccc tgaggagaaa atctgggagg agctgagtgt gttagaggtg tttgagggga gggaagacag tatcttcggg gatcccaaga agctgctcac ccaatatttc gtgcaggaaa actacctgga gtaccggcag gtccccggca gtgatcctgc atgctatgag ttcctgtggg gtccaagggc cctcattgaa accagctatg tgaaagtcct gcaccatatg gtaaagatca gtggaggacc tcgcatttcc tacccactcc tgcatgagtg ggctttgaga gagggggaag agtga. It is sometimes possible for the material contained within the vial of "MAGEA6, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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