MADD cdna clone
MADD cDNA Clone
Gene Names
MADD; DENN; IG20; RAB3GEP
Synonyms
MADD; MADD cDNA Clone; MADD cdna clone
Sequence
atggtgcaaaagaagaagttctgtcctcggttacttgactatctagtgatcgtaggggccaggcacccgagcagtgatagcgtggcccagactcctgaattgctacggcgataccccttggaggatcacactgagtttcccctgcccccagatgtagtgttcttctgccagcccgagggctgcctgagcgtgcggcagcggcgcatgagccttcgggatgatacctcttttgtcttcaccctcactgacaaggacactggagtcacgcgatatggcatctgtgttaacttctaccgctccttccaaaagcgaatctctaaggagaagggggaaggtggggcagggtcccgtgggaaggaaggaacccatgccacctgtgcctcagaagagggtggcactgagagctcagagagtggctcatccctgcagcctctcagtgctgactctacccctgatgtgaaccagtctcctcggggcaaacgccgggccaaggcggggagccgctcccgcaacagtactctcacgtccctgtgcgtgctcagccactaccctttcttctccaccttccgagagtgtttgtatactctcaagcgcctggtggactgctgtagtgagcgccttctgggcaagaaactgggcatccctcgaggcgtacaaagggacaccatgtggcggatctttactggatcgctgctggtagaggagaagtcaagtgcccttctgcatgaccttcgagagattgaggcctggatctatcgattgctgcgctccccagtacccgtctctgggcagaagcgagtagacatcgaggtcctaccccaagagctccagccagctctgacctttgctcttccagacccatctcgattcaccctagtggatttcccactgcaccttcccttggaacttctaggtgtggacgcctgtctccaggtgctaacctgcattctgttagagcacaaggtggtgctacagtcccgagactacaatgcactctccatgtctgtgatggcattcgtggcaatgatctacccactggaatatatgtttcctgtcatcccgctgctacccacctgcatggcatcagcagagcagctgctgttggctccaaccccgtacatcattggggttcctgccagcttcttcctctacaaactggacttcaaaatgcctgatgatgtatggctagtggatctggacagcaatagggtgattgcccccaccaatgcagaagtgctgcctatcctgccagaaccagaatcactagagctgaaaaagcatttaaagcaggccttggccagcatgagtctcaacacccagcccatcctcaatctggagaaatttcatgagggccaggagatcccccttctcttgggaaggccttctaatgacctgcagtccacaccgtccactgaattcaacccactcatctatggcaatgatgtggattctgtggatgttgcaaccagggttgccatggtacggttcttcaattccgccaacgtgctgcagggatttcagatgcacacgcgtaccctgcgcctctttcctcggcctgtggtagcttttcaagctggctcctttctagcctcacgtccccggcagactccttttgccgagaaattggccaggactcaggctgtggagtactttggggaatggatccttaaccccaccaactatgcctttcagcgaattcacaacaatatgtttgatccagccctgattggtgacaagccaaagtggtatgctcatcagctgcagcctatccactatcgcgtctatgacagcaattcccagctggctgaggccctgagtgtaccaccagagcgggactctgactccgaacctactgatgatagtggcagtgatagtatggattatgacgattcaagctcttcttactcctcccttggtgactttgtcagtgaaatgatgaaatgtgacattaatggtgatactcccaatgtggaccctctgacacatgcagcactgggggatgccagcgaggtggagattgacgagctgcagaatcagaaggaagcagaagagcctggcccagacagtgagaactctcaggaaaacaccccactgcgctccagctctagcaccacagccagcagcagccccagcactgtcatccacggagccaactctgaacctgctgactctacggagatggatgataaggcagcagtaggcgtctccaagcccctcccttccgtgcctcccagcattggcaaatcgaacgtggacagacgtcaggcagaaattggagagggggctcaaaagctgctgcggcccaacagcttgagactggcaagtgactcagatgcagagtcagactctcgggcaagctctcccaactccaccgtctccaacaccagcaccgagggcttcgggggcatcatgtcttttgccagcagcctctatcggaaccacagtaccagcttcagtctttcaaacctcacactgcccaccaaaggtgcccgagagaaggccacgcccttccccagtctgaaaggaaacaggagggcgttagtggatcagaagtcatctgtcattaaacacagcccaacagtgaaaagagaacctccatcaccccagggtcgatccagcaattctagtgagaaccagcagttcctgaaggaggtggtgcacagcgtgctggacggccagggagttggctggctcaacatgaaaaaggtgcgcgggctgctggagagcgagcagctgcgagtctttgtcctgagcaagctgaaccgcatggtgcagtcagaggacgatgcccggcaggacatcatcccggatgtggagatcagtcggaaggtgtacaagggaatgttagacctcctcaagtgtacagtcctcagcttggagcagtcctatgcccacgcgggtctgggtggcatggccagcatctttgggtttttggagattgcccagacccactactatagtaaagaaccagacaagcggaagagaagtccaacagaaagtgtaaataccccagttggcaaggatcctggcctagctgggcggggggacccaaaggctatggcacaactgagagttccacaactgggacctcgggcaccaagtgccacaggaaagggtcctaaggaactggacaccagaagtttaaaggaagaaaattttatagcatctattgggcctgaagtaatcaaacctgtctttgaccttggtgagacagaggagaaaaagtcccagatcagcgcagacagtggtgtgagcctgacgtctagttcccagaggactgatcaagactctgtcatcggcgtgagtccagctgttatgatccgcagctcaagtcaggattctgaagttagcaccgtgagtaatagctctggagagacccttggagctgacagtgacttgagcagcaatgcaggtgatggaccaggtggcgagggcagtgttcacctggcaagctctcggggcactttgtctgatagtgaaattgagaccaactctgccacaagcactatctttggtaaagcccacagcttgaagccaagcataaaggagaagctggcaggcagccccattcgtacttctgaagatgtgagccagcgagtctatctctatgagggactcctaggcaaagagcgttctactttatgggaccaaatgcaattctgggaagatgccttcttagatgctgtgatgttggagagagaagggatgggtatggaccagggtccccaggaaatgatcgacaggtacctgtcccttggagaacatgaccggaagcgcctggaagatgatgaagatcgcttgctggccacacttctgcacaacctcatctcctacatgctgctgatgaaggtaaataagaatgacatccgcaagaaggtgaggcgcctaatgggaaagtcgcacattgggcttgtgtacagccagcaaatcaatgaggtgcttgatcagctggcgaacctgaatggacgcgatctctctatctggtccagtggcagccggcacatgaagaagcagacatttgtggtacatgcagggacagatacaaacggagatatctttttcatggaggtgtgcgatgactgtgtggtgttgcgtagtaacatcggaacagtgtatgagcgctggtggtacgagaagctcatcaacatgacctactgtcccaagacgaaggtgttgtgcttgtggcgtagaaatggctctgagacccagctcaacaagttctatactaaaaagtgtcgggagctgtactactgtgtgaaggacagcatggagcgcgctgccgcccgacagcaaagcatcaaacccggacctgaattgggtggcgagttccctgtgcaggacctgaagactggtgagggtggcctgctgcaggtgaccctggaagggatcaacctcaaattcatgcacaatcaggttttcatagagctgaatcacattaaaaagtgcaatacagttcgaggcgtctttgtcctggaggaatttgttcctgaaattaaagaagtggtgagccacaagtacaagacaccaatggcccacgaaatctgctactccgtattatgtctcttctcgtacgtggctgcagttcatagcagtgaggaagatctcagaaccccgccccggcctgtctctagctga
Sequence Length
4635
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
171,006 Da
NCBI Official Full Name
Homo sapiens MAP-kinase activating death domain, mRNA
NCBI Official Synonym Full Names
MAP kinase activating death domain
NCBI Official Symbol
MADD
NCBI Official Synonym Symbols
DENN; IG20; RAB3GEP
NCBI Protein Information
MAP kinase-activating death domain protein
UniProt Protein Name
MAP kinase-activating death domain protein
Protein Family
UniProt Gene Name
MADD
UniProt Entry Name
MADD_HUMAN
NCBI Description
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
MADD: a guanine nucleotide exchange factor (GEF) that activates RAB3A/C/D. A GEF for Rab27A/B in melanocytes and during isoproterenol (IPR)-stimulated amylase release from rat parotid acinar cells. Plays a significant role in regulating cell proliferation, survival and death through alternatively spliced isoforms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis). Interacts with the death domain of TNFRSF1A through its own death domain. Highly expressed in fetal brain and kidney, adult testis, ovary, brain and heart. Overexpression of MADD activates the mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase (ERK). Expression of the MADD death domain stimulates both the ERK and c-JUN N-terminal kinase MAP kinases and induces the phosphorylation of cytosolic phospholipase A2. Isoform 1 is pro-apoptotic, isoform 5 is anti-apoptotic and isoform 3 and isoform 4 have no effect. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines. Isoform 5 is associated with increased cell proliferation and isoform 2 with decreased proliferation. Belongs to the MADD family. Seven isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rab; GEFs; Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: cytoplasm; cytosol; integral to membrane; plasma membrane
Molecular Function: death receptor binding; protein binding; protein kinase activator activity; Rab guanyl-nucleotide exchange factor activity
Biological Process: activation of MAPK activity; cell surface receptor linked signal transduction; regulation of apoptosis; regulation of cell cycle; regulation of Rab protein signal transduction
Research Articles on MADD
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Product Notes
The MADD madd (Catalog #AAA1271097) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtgcaaa agaagaagtt ctgtcctcgg ttacttgact atctagtgat cgtaggggcc aggcacccga gcagtgatag cgtggcccag actcctgaat tgctacggcg ataccccttg gaggatcaca ctgagtttcc cctgccccca gatgtagtgt tcttctgcca gcccgagggc tgcctgagcg tgcggcagcg gcgcatgagc cttcgggatg atacctcttt tgtcttcacc ctcactgaca aggacactgg agtcacgcga tatggcatct gtgttaactt ctaccgctcc ttccaaaagc gaatctctaa ggagaagggg gaaggtgggg cagggtcccg tgggaaggaa ggaacccatg ccacctgtgc ctcagaagag ggtggcactg agagctcaga gagtggctca tccctgcagc ctctcagtgc tgactctacc cctgatgtga accagtctcc tcggggcaaa cgccgggcca aggcggggag ccgctcccgc aacagtactc tcacgtccct gtgcgtgctc agccactacc ctttcttctc caccttccga gagtgtttgt atactctcaa gcgcctggtg gactgctgta gtgagcgcct tctgggcaag aaactgggca tccctcgagg cgtacaaagg gacaccatgt ggcggatctt tactggatcg ctgctggtag aggagaagtc aagtgccctt ctgcatgacc ttcgagagat tgaggcctgg atctatcgat tgctgcgctc cccagtaccc gtctctgggc agaagcgagt agacatcgag gtcctacccc aagagctcca gccagctctg acctttgctc ttccagaccc atctcgattc accctagtgg atttcccact gcaccttccc ttggaacttc taggtgtgga cgcctgtctc caggtgctaa cctgcattct gttagagcac aaggtggtgc tacagtcccg agactacaat gcactctcca tgtctgtgat ggcattcgtg gcaatgatct acccactgga atatatgttt cctgtcatcc cgctgctacc cacctgcatg gcatcagcag agcagctgct gttggctcca accccgtaca tcattggggt tcctgccagc ttcttcctct acaaactgga cttcaaaatg cctgatgatg tatggctagt ggatctggac agcaataggg tgattgcccc caccaatgca gaagtgctgc ctatcctgcc agaaccagaa tcactagagc tgaaaaagca tttaaagcag gccttggcca gcatgagtct caacacccag cccatcctca atctggagaa atttcatgag ggccaggaga tcccccttct cttgggaagg ccttctaatg acctgcagtc cacaccgtcc actgaattca acccactcat ctatggcaat gatgtggatt ctgtggatgt tgcaaccagg gttgccatgg tacggttctt caattccgcc aacgtgctgc agggatttca gatgcacacg cgtaccctgc gcctctttcc tcggcctgtg gtagcttttc aagctggctc ctttctagcc tcacgtcccc ggcagactcc ttttgccgag aaattggcca ggactcaggc tgtggagtac tttggggaat ggatccttaa ccccaccaac tatgcctttc agcgaattca caacaatatg tttgatccag ccctgattgg tgacaagcca aagtggtatg ctcatcagct gcagcctatc cactatcgcg tctatgacag caattcccag ctggctgagg ccctgagtgt accaccagag cgggactctg actccgaacc tactgatgat agtggcagtg atagtatgga ttatgacgat tcaagctctt cttactcctc ccttggtgac tttgtcagtg aaatgatgaa atgtgacatt aatggtgata ctcccaatgt ggaccctctg acacatgcag cactggggga tgccagcgag gtggagattg acgagctgca gaatcagaag gaagcagaag agcctggccc agacagtgag aactctcagg aaaacacccc actgcgctcc agctctagca ccacagccag cagcagcccc agcactgtca tccacggagc caactctgaa cctgctgact ctacggagat ggatgataag gcagcagtag gcgtctccaa gcccctccct tccgtgcctc ccagcattgg caaatcgaac gtggacagac gtcaggcaga aattggagag ggggctcaaa agctgctgcg gcccaacagc ttgagactgg caagtgactc agatgcagag tcagactctc gggcaagctc tcccaactcc accgtctcca acaccagcac cgagggcttc gggggcatca tgtcttttgc cagcagcctc tatcggaacc acagtaccag cttcagtctt tcaaacctca cactgcccac caaaggtgcc cgagagaagg ccacgccctt ccccagtctg aaaggaaaca ggagggcgtt agtggatcag aagtcatctg tcattaaaca cagcccaaca gtgaaaagag aacctccatc accccagggt cgatccagca attctagtga gaaccagcag ttcctgaagg aggtggtgca cagcgtgctg gacggccagg gagttggctg gctcaacatg aaaaaggtgc gcgggctgct ggagagcgag cagctgcgag tctttgtcct gagcaagctg aaccgcatgg tgcagtcaga ggacgatgcc cggcaggaca tcatcccgga tgtggagatc agtcggaagg tgtacaaggg aatgttagac ctcctcaagt gtacagtcct cagcttggag cagtcctatg cccacgcggg tctgggtggc atggccagca tctttgggtt tttggagatt gcccagaccc actactatag taaagaacca gacaagcgga agagaagtcc aacagaaagt gtaaataccc cagttggcaa ggatcctggc ctagctgggc ggggggaccc aaaggctatg gcacaactga gagttccaca actgggacct cgggcaccaa gtgccacagg aaagggtcct aaggaactgg acaccagaag tttaaaggaa gaaaatttta tagcatctat tgggcctgaa gtaatcaaac ctgtctttga ccttggtgag acagaggaga aaaagtccca gatcagcgca gacagtggtg tgagcctgac gtctagttcc cagaggactg atcaagactc tgtcatcggc gtgagtccag ctgttatgat ccgcagctca agtcaggatt ctgaagttag caccgtgagt aatagctctg gagagaccct tggagctgac agtgacttga gcagcaatgc aggtgatgga ccaggtggcg agggcagtgt tcacctggca agctctcggg gcactttgtc tgatagtgaa attgagacca actctgccac aagcactatc tttggtaaag cccacagctt gaagccaagc ataaaggaga agctggcagg cagccccatt cgtacttctg aagatgtgag ccagcgagtc tatctctatg agggactcct aggcaaagag cgttctactt tatgggacca aatgcaattc tgggaagatg ccttcttaga tgctgtgatg ttggagagag aagggatggg tatggaccag ggtccccagg aaatgatcga caggtacctg tcccttggag aacatgaccg gaagcgcctg gaagatgatg aagatcgctt gctggccaca cttctgcaca acctcatctc ctacatgctg ctgatgaagg taaataagaa tgacatccgc aagaaggtga ggcgcctaat gggaaagtcg cacattgggc ttgtgtacag ccagcaaatc aatgaggtgc ttgatcagct ggcgaacctg aatggacgcg atctctctat ctggtccagt ggcagccggc acatgaagaa gcagacattt gtggtacatg cagggacaga tacaaacgga gatatctttt tcatggaggt gtgcgatgac tgtgtggtgt tgcgtagtaa catcggaaca gtgtatgagc gctggtggta cgagaagctc atcaacatga cctactgtcc caagacgaag gtgttgtgct tgtggcgtag aaatggctct gagacccagc tcaacaagtt ctatactaaa aagtgtcggg agctgtacta ctgtgtgaag gacagcatgg agcgcgctgc cgcccgacag caaagcatca aacccggacc tgaattgggt ggcgagttcc ctgtgcagga cctgaagact ggtgagggtg gcctgctgca ggtgaccctg gaagggatca acctcaaatt catgcacaat caggttttca tagagctgaa tcacattaaa aagtgcaata cagttcgagg cgtctttgtc ctggaggaat ttgttcctga aattaaagaa gtggtgagcc acaagtacaa gacaccaatg gcccacgaaa tctgctactc cgtattatgt ctcttctcgt acgtggctgc agttcatagc agtgaggaag atctcagaac cccgccccgg cctgtctcta gctga. It is sometimes possible for the material contained within the vial of "MADD, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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