LRRK2 cdna clone
LRRK2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Uniprot Description
LRRK2: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). May play a role in the etiology of Parkinson disease. May also have GTPase activity. Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Interacts with PARK2, PRDX3 and TPCN2. Expressed throughout the adult brain, but at a lower level than in heart and liver. Expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8). A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, TKL; TKL group; LRRK family
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: axon; caveola; cell soma; cytoplasm; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; endosome; extracellular space; Golgi apparatus; Golgi-associated vesicle; growth cone; inclusion body; intracellular; lysosome; microvillus; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; neuron projection; perikaryon; plasma membrane; terminal button
Molecular Function: actin binding; clathrin binding; glycoprotein binding; GTP binding; GTP-dependent protein kinase activity; GTPase activator activity; GTPase activity; identical protein binding; kinase activity; MAP kinase kinase activity; microtubule binding; protein binding; protein homodimerization activity; protein kinase A binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling complex scaffold activity; Rho GTPase binding; SNARE binding; syntaxin-1 binding; tubulin binding
Biological Process: activation of MAPK activity; activation of MAPKK activity; calcium-mediated signaling; cellular response to starvation; determination of adult life span; endocytosis; Golgi organization and biogenesis; GTP metabolic process; intracellular distribution of mitochondria; lysosome organization and biogenesis; MAPKKK cascade; mitochondrion localization; mitochondrion organization and biogenesis; negative regulation of macroautophagy; negative regulation of protein amino acid phosphorylation; negative regulation of protein binding; neurite morphogenesis; neuromuscular junction development; olfactory bulb development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of dopamine receptor signaling pathway; positive regulation of MAP kinase activity; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of autophagy; regulation of calcium-mediated signaling; regulation of dopamine receptor signaling pathway; regulation of excitatory postsynaptic membrane potential; regulation of locomotion; regulation of membrane potential; regulation of mitochondrial depolarization; regulation of neuron maturation; regulation of synaptic transmission, glutamatergic; response to oxidative stress; tangential migration from the subventricular zone to the olfactory bulb; Wnt receptor signaling pathway through beta-catenin
Disease: Parkinson Disease 8, Autosomal Dominant
Research Articles on LRRK2
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Product Notes
The LRRK2 lrrk2 (Catalog #AAA1276902) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctagtg gcagctgtca ggggtgcgaa gaggacgagg aaactctgaa gaagttgata gtcaggctga acaatgtcca ggaaggaaaa cagatagaaa cgctggtcca aatcctggag gatctgctgg tgttcacgta ctccgagcac gcctccaagt tatttcaagg caaaaatatc catgtgcctc tgttgatcgt cttggactcc tatatgagag tcgcgagtgt gcagcaggtg ggttggtcac ttctgtgcaa attaatagaa gtctgtccag gtacaatgca aagcttaatg ggaccccagg atgttggaaa tgattgggaa gtccttggtg ttcaccaatt gattcttaaa atgctaacag ttcataatgc cagtgtaaac ttgtcagtga ttggactgaa gaccttagat ctcctcctaa cttcaggtaa aatcaccttg ctgatactgg atgaagaaag tgatattttc atgttaattt ttgatgccat gcactcattt ccagccaatg atgaagtcca gaaacttgga tgcaaagctt tacatgtgct gtttgagaga gtctcagagg agcaactgac tgaatttgtt gagaacaaag attatatgat attgttaagt gcgttaacaa attttaaaga tgaagaggaa attgtgcttc atgtgctgca ttgtttacat tccctagcga ttccttgcaa taatgtggaa gtcctcatga gtggcaatgt caggtgttat aatattgtgg tggaagctat gaaagcattc cctatgagtg aaagaattca agaagtgagt tgctgtttgc tccataggct tacattaggt aattttttca atatcctggt attaaacgaa gtccatgagt ttgtggtgaa agctgtgcag cagtacccag agaatgcagc attgcagatc tcagcgctca gctgtttggc cctcctcact gagactattt tcttaaatca agatttagag gaaaagaatg agaatcaaga gaatgatgat gagggggaag aagataaatt gttttggctg gaagcctgtt acaaagcatt aacgtggcat agaaagaaca agcacgtgca ggaggccgca tgctgggcac taaataatct ccttatgtac caaaacagtt tacatgagaa gattggagat gaagatggcc atttcccagc tcatagggaa gtgatgctct ccatgctgat gcattcttca tcaaaggaag ttttccaggc atctgcgaat gcattgtcaa ctctcttaga acaaaatgtt aatttcagaa aaatactgtt atcaaaagga atacacctga atgttttgga gttaatgcag aagcatatac attctcctga agtggctgaa agtggctgta aaatgctaaa tcatcttttt gaaggaagca acacttccct ggatataatg gcagcagtgg tccccaaaat actaacagtt atgaaacgtc atgagacatc attaccagtg cagctggagg cgcttcgagc tattttacat tttatagtgc ctggcatgcc agaagaatcc agggaggata cagaatttca tcataagcta aatatggtta aaaaacagtg tttcaagaat gatattcaca aactggtcct agcagctttg aacaggttca ttggaaatcc tgggattcag aaatgtggat taaaagtaat ttcttctatt gtacattttc ctgatgcatt agagatgtta tccctggaag gtgctatgga ttcagtgctt cacacactgc agatgtatcc agatgaccaa gaaattcagt gtctgggttt aagtcttata ggatacttga ttacaaagaa gaatgtgttc ataggaactg gacatctgct ggcaaaaatt ctggtttcca gcttataccg atttaaggat gttgctgaaa tacagactaa aggatttcag acaatcttag caatcctcaa attgtcagca tctttttcta agctgctggt gcatcattca tttgacttag taatattcca tcaaatgtct tccaatatca tggaacaaaa ggatcaacag tttctaaacc tctgttgcaa gtgttttgca aaagtagcta tggatgatta cttaaaaaat gtgatgctag agagagcgtg tgatcagaat aacagcatca tggttgaatg cttgcttcta ttgggagcag atgccaatca agcaaaggag ggatcttctt taatttgtca ggtatgtgag aaagagagca gtcccaaatt ggtggaactc ttactgaata gtggatctcg tgaacaagat gtacgaaaag cgttgacgat aagcattggg aaaggtgaca gccagatcat cagcttgctc ttaaggaggc tggccctgga tgtggccaac aatagcattt gccttggagg attttgtata ggaaaagttg aaccttcttg gcttggtcct ttatttccag ataagacttc taatttaagg aaacaaacaa atatagcatc tacactagca agaatggtga tcagatatca gatgaaaagt gctgtggaag aaggaacagc ctcaggcagc gatggaaatt tttctgaaga tgtgctgtct aaatttgatg aatggacctt tattcctgac tcttctatgg acagtgtgtt tgctcaaagt gatgacctgg atagtgaagg aagtgaaggc tcatttcttg tgaaaaagaa atctaattca attagtgtag gagaatttta ccgagatgcc gtattacagc gttgctcacc aaatttgcaa agacattcca attccttggg gcccattttt gatcatgaag atttactgaa gcgaaaaaga aaaatattat cttcagatga ttcactcagg tcatcaaaac ttcaatccca tatgaggcat tcagacagca tttcttctct ggcttctgag agagaatata ttacatcact agacctttca gcaaatgaac taagagatat tgatgcccta agccagaaat gctgtataag tgttcatttg gagcatcttg aaaagctgga gcttcaccag aatgcactca cgagctttcc acaacagcta tgtgaaactc tgaagagttt gacacatttg gacttgcaca gtaataaatt tacatcattt ccttcttatt tgttgaaaat gagttgtatt gctaatcttg atgtctctcg aaatgacatt ggaccctcag tggttttaga tcctacagtg aaatgtccaa ctctgaaaca gtttaacctg tcatataacc agctgtcttt tgtacctgag aacctcactg atgtggtaga gaaactggag cagctcattt tagaaggaaa taaaatatca gggatatgct cccccttgag actgaaggaa ctgaagattt taaaccttag taagaaccac atttcatccc tatcagagaa ctttcttgag gcttgtccta aagtggagag tttcagtgcc agaatgaatt ttcttgctgc tatgcctttc ttgcctcctt ctatgacaat cctaaaatta tctcagaaca aattttcctg tattccagaa gcaattttaa atcttccaca cttgcggtct ttagatatga gcagcaatga tattcagtac ctaccaggtc ccgcacactg gaaatctttg aacttaaggg aactcttatt tagccataat cagatcagca tcttggactt gagtgaaaaa gcatatttat ggtctagagt agagaaactg catctttctc acaataaact gaaagagatt cctcctgaga ttggctgtct tgaaaatctg acatctctgg atgtcagtta caacttggaa ctaagatcct ttcccaatga aatggggaaa ttaagcaaaa tatgggatct tcctttggat gaactgcatc ttaactttga ttttaaacat ataggatgta aagccaaaga catcataagg tttcttcaac agcgattaaa aaaggctgtg ccttataacc gaatgaaact tatgattgtg ggaaatactg ggagtggtaa aaccacctta ttgcagcaat taatgaaaac caagaaatca gatcttggaa tgcaaagtgc cacagttggc atagatgtga aagactggcc tatccaaata agagacaaaa gaaagagaga tctcgtccta aatgtgtggg attttgcagg tcgtgaggaa ttctatagta ctcatcccca ttttatgacg cagcgagcat tgtaccttgc tgtctatgac ctcagcaagg gacaggctga agttgatgcc atgaagcctt ggctcttcaa tataaaggct cgcgcttctt cttcccctgt gattctcgtt ggcacacatt tggatgtttc tgatgagaag caacgcaaag cctgcatgag taaaatcacc aaggaactcc tgaataagcg agggttccct gccatacgag attaccactt tgtgaatgcc accgaggaat ctgatgcttt ggcaaaactt cggaaaacca tcataaacga gagccttaat ttcaagatcc gagatcagct tgttgttgga cagctgattc cagactgcta tgtagaactt gaaaaaatca ttttatcgga gcgtaaaaat gtgccaattg aatttcccgt aattgaccgg aaacgattat tacaactagt gagagaaaat cagctgcagt tagatgaaaa tgagcttcct cacgcagttc actttctaaa tgaatcagga gtccttcttc attttcaaga cccagcactg cagttaagtg acttgtactt tgtggaaccc aagtggcttt gtaaaatcat ggcacagatt ttgacagtga aagtggaagg ttgtccaaaa caccctaagg gaattatttc gcgtagagat gtggaaaaat ttctttcaaa gaaaaggaaa tttccaaaga actacatgac acagtatttt aagctcctag aaaaattcca gattgctttg ccaataggag aagaatattt gctggttcca agcagtttgt ctgaccacag gcctgtgata gagcttcccc attgtgagaa ctctgaaatt atcatccgac tatatgaaat gccttatttt ccaatgggat tttggtcaag attaatcaat cgattacttg agatttcacc ttacatgctt tcagggagag aacgagcact tcgcccaaac agaatgtatt ggcgacaagg catttactta aattggtctc ctgaagctta ttgtctggta ggatctgaag tcttagacaa tcatccagag agtttcttaa aaattacagt tccttcttgt agaaaaggct gtattctttt gggccaagtt gtggaccaca ttgattctct catggaagaa tggtttcctg ggttgctgga gattgatatt tgtggtgaag gagaaactct gttgaagaaa tgggcattat atagttttaa tgatggcgaa gaacatcaaa aaatcttact tgatgacttg atgaagaaag cagaggaagg agatctctta gtaaatccag atcaaccaag gctcaccatt ccaatatctc agattgcccc tgacttgatt ttggctgacc tgcctagaaa tattatgttg aataatgatg agttggaatt tgaacaagct ccagagtttc tcctaggtga tggcagtttt ggatcagttt accgagcagc ctatgaagga gaagaagtgg ctgtgaagat ttttaataaa catacatcac tcaggctgtt aagacaagag cttgtggtgc tttgccacct ccaccacccc agtttgatat ctttgctggc agctgggatt cgtccccgga tgttggtgat ggagttagcc tccaagggtt ccttggatcg cctgcttcag caggacaaag ccagcctcac tagaacccta cagcacagga ttgcactcca cgtagctgat ggtttgagat acctccactc agccatgatt atataccgag acctgaaacc ccacaatgtg ctgcttttca cactgtatcc caatgctgcc atcattgcaa agattgctga ctacggcatt gctcagtact gctgtagaat ggggataaaa acatcagagg gcacaccagg gtttcgtgca cctgaagttg ccagaggaaa tgtcatttat aaccaacagg ctgatgttta ttcatttggt ttactactct atgacatttt gacaactgga ggtagaatag tagagggttt gaagtttcca aatgagtttg atgaattaga aatacaagga aaattacctg atccagttaa agaatatggt tgtgccccat ggcctatggt tgaaaaatta attaaacagt gtttgaaaga aaatcctcaa gaaaggccta cttctgccca ggtctttgac attttgaatt cagctgaatt agtctgtctg acgagacgca ttttattacc taaaaacgta attgttgaat gcatggttgc tacacatcac aacagcagga atgcaagcat ttggctgggc tgtgggcaca ccgacagagg acagctctca tttcttgact taaatactga aggatacact tctgaggaag ttgctgatag tagaatattg tgcttagcct tggtgcatct tcctgttgaa aaggaaagct ggattgtgtc tgggacacag tctggtactc tcctggtcat caataccgaa gatgggaaaa agagacatac cctagaaaag atgactgatt ctgtcacttg tttgtattgc aattcctttt ccaagcaaag caaacaaaaa aattttcttt tggttggaac cgctgatggc aagttagcaa tttttgaaga taagactgtt aagcttaaag gagctgctcc tttgaagata ctaaatatag gaaatgtcag tactccattg atgtgtttga gtgaatccac aaattcaacg gaaagaaatg taatgtgggg aggatgtggc acaaagattt tctccttttc taatgatttc accattcaga aactcattga gacaagaaca agccaactgt tttcttatgc agctttcagt gattccaaca tcataacagt ggtggtagac actgctctct atattgctaa gcaaaatagc cctgttgtgg aagtgtggga taagaaaact gaaaaactct gtggactaat agactgcgtg cactttttaa gggaggtaac ggtaaaagaa aacaaggaat caaaacacaa aatgtcttat tctgggagag tgaaaaccct ctgccttcag aagaacactg ctctttggat aggaactgga ggaggccata ttttactcct ggatctttca actcgtcgac ttatacgtgt aatttacaac ttttgtaatt cggtcagagt catgatgaca gcacagctag gaagccttaa aaatgtcatg ctggtattgg gctacaaccg gaaaaatact gaaggtacac aaaagcagaa agagatacaa tcttgcttga ccgtttggga catcaatctt ccacatgaag tgcaaaattt agaaaaacac attgaagtga gaaaagaatt agctgaaaaa atgagacgaa catctgttga gtaa. It is sometimes possible for the material contained within the vial of "LRRK2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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