LPHN1 cdna clone
LPHN1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Uniprot Description
latrophilin 1: Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 2
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: axon; growth cone; neuron projection; plasma membrane; presynaptic membrane; synapse
Molecular Function: cell adhesion molecule binding; latrotoxin receptor activity; protein binding
Biological Process: heterophilic cell adhesion
Research Articles on LPHN1
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Product Notes
The LPHN1 adgrl1 (Catalog #AAA7046745) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggggctga tttcccacct agagaggttg atggcagaag gaaaatgggg aggcactggg gttgtggagg gcatgggtat ggctgaggag ggtgctggga acggcaaggc ggtctggggg atggggaggg gcaaaggtga gagatcacct tccctatcct ccaccttccc gcagggaaga cgaagccagg tgccagggct ggggtcggga cacccatgtt ctgggcggct tgaccccaaa tcccagaccc cggaagctcc aggctcggga tgtgtcctga gcacctgtcc cggccccctc ctctccagcc tgtcaggcca gcctccccag cccccttccc tcaactctag gggcagcata gccccaggcc accctagccc agcccctgca ttgccgtttc cccagaggtg gcccctccac ctctgctctg acctctcccc atctctctgc ccctcctttt ctcacaagtg ccatgagttt tcaaacatct tcgggtctca gcctgctgct gccatgaact ttgttgggtt aagggggagg ggctctagga aggaactggg gggaagggga caggtaggtg gctggaggga ccctttttgc tgctag. It is sometimes possible for the material contained within the vial of "LPHN1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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