LAMC2 cdna clone
LAMC2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]
Uniprot Description
LAMC2: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. Defects in LAMC2 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Extracellular matrix; Secreted, signal peptide; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q25-q31
Cellular Component: extracellular space; laminin-5 complex; laminin-2 complex; membrane; perinuclear region of cytoplasm; extracellular region; cell cortex
Molecular Function: heparin binding
Biological Process: extracellular matrix disassembly; hemidesmosome assembly; epidermis development; extracellular matrix organization and biogenesis; cell adhesion
Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa, Junctional, Herlitz Type
Research Articles on LAMC2
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Product Notes
The LAMC2 lamc2 (Catalog #AAA1276276) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCCTGCGC TCTGGCTGGG CTGCTGCCTC TGCTTCTCGC TCCTCCTGCC CGCAGCCCGG GCCACCTCCA GGAGGGAAGT CTGTGATTGC AATGGGAAGT CCAGGCAGTG TATCTTTGAT CGGGAACTTC ACAGACAAAC TGGTAATGGA TTCCGCTGCC TCAACTGCAA TGACAACACT GATGGCATTC ACTGCGAGAA GTGCAAGAAT GGCTTTTACC GGCACAGAGA AAGGGACCGC TGTTTGCCCT GCAATTGTAA CTCCAAAGGT TCTCTTAGTG CTCGATGTGA CAACTCCGGA CGGTGCAGCT GTAAACCAGG TGTGACAGGA GCCAGATGCG ACCGATGTCT GCCAGGCTTC CACATGCTCA TGGATGCGGG GTGCACCCAA GACCAGAGAC TGCTAGACTC CAAGTGTGAC TGTGACCCAG CTGGCATCGC AGGGCCCTGT GACGCGGGCC GCTGTGTCTG CAAGCCAGCT GTCACTGGAG AACGCTGTGA TAGGTGTCGA TCAGGTTACT ATAATCTGGA TGGGGGGAAC CCTGAGGGCT GTACCCAGTG TTTCTGCTAT GGGCATTCAG CCAGCTGCCG CAGCTCTGCA GAATACAGTG TCCATAAGAT CACCTCTACC TTTCATCAAG ATGTTGATGG CTGGAAGGCT GTCCAACGAA ATGGGTCTCC TGCAAAGCTC CAATGGTCAC AGCGCCATCA AGATGTGTTT AGCTCAGCCC AACGACTAGA CCCTGTCTAT TTTGTGGCTC CTGCCAAATT TCTTGGGAAT CAACAGGTGA GCTATGGTCA AAGCCTGTCC TTTGACTACC GTGTGGACAG AGGAGGCAGA CACCCATCTG CCCATGATGT GATTCTGGAA GGTGCTGGTC TACGGATCAC AGCTCCCTTG ATGCCACTTG GCAAGACACT GCCTTGTGGG CTCACCAAGA CTTACACATT CAGGTTAAAT GAGCATCCAA GCAATAATTG GAGCCCCCAG CTGAGTTACT TTGAGTATCG AAGGTTACTG CGGAATCTCA CAGCCCTCCG CATCCGAGCT ACATATGGAG AATACAGTAC TGGGTACATT GACAATGTGA CCCTGATTTC AGCCCGCCCT GTCTCTGGAG CCCCAGCACC CTGGGTTGAA CAGTGTATAT GTCCTGTTGG GTACAAGGGG CAATTCTGCC AGGATTGTGC TTCTGGCTAC AAGAGAGATT CAGCGAGACT GGGGCCTTTT GGCACCTGTA TTCCTTGTAA CTGTCAAGGG GGAGGGGCCT GTGATCCAGA CACAGGAGAT TGTTATTCAG GGGATGAGAA TCCTGACATT GAGTGTGCTG ACTGCCCAAT TGGTTTCTAC AACGATCCGC ACGACCCCCG CAGCTGCAAG CCATGTCCCT GTCATAACGG GTTCAGCTGC TCAGTGATGC CGGAGACGGA GGAGGTGGTG TGCAATAACT GCCCTCCCGG GGTCACCGGT GCCCGCTGTG AGCTCTGTGC TGATGGCTAC TTTGGGGACC CCTTTGGTGA ACATGGCCCA GTGAGGCCTT GTCAGCCCTG TCAATGCAAC AACAATGTGG ACCCCAGTGC CTCTGGGAAT TGTGACCGGC TGACAGGCAG GTGTTTGAAG TGTATCCACA ACACAGCCGG CATCTACTGC GACCAGTGCA AAGCAGGCTA CTTCGGGGAC CCATTGGCTC CCAACCCAGC AGACAAGTGT CGAGCTTGCA ACTGTAACCC CATGGGCTCA GAGCCTGTAG GATGTCGAAG TGATGGCACC TGTGTTTGCA AGCCAGGATT TGGTGGCCCC AACTGTGAGC ATGGAGCATT CAGCTGTCCA GCTTGCTATA ATCAAGTGAA GATTCAGATG GATCAGTTTA TGCAGCAGCT TCAGAGAATG GAGGCCCTGA TTTCAAAGGC TCAGGGTGGT GATGGAGTAG TACCTGATAC AGAGCTGGAA GGCAGGATGC AGCAGGCTGA GCAGGCCCTT CAGGACATTC TGAGAGATGC CCAGATTTCA GAAGGTGCTA GCAGATCCCT TGGTCTCCAG TTGGCCAAGG TGAGGAGCCA AGAGAACAGC TACCAGAGCC GCCTGGATGA CCTCAAGATG ACTGTGGAAA GAGTTCGGGC TCTGGGAAGT CAGTACCAGA ACCGAGTTCG GGATACTCAC AGGCTCATCA CTCAGATGCA GCTGAGCCTG GCAGAAAGTG AAGCTTCCTT GGGAAACACT AACATTCCTG CCTCAGACCA CTACGTGGGG CCAAATGGCT TTAAAAGTCT GGCTCAGGAG GCCACAAGAT TAGCAGAAAG CCACGTTGAG TCAGCCAGTA ACATGGAGCA ACTGACAAGG GAAACTGAGG ACTATTCCAA ACAAGCCCTC TCACTGGTGC GCAAGGCCCT GCATGAAGGA GTCGGAAGCG GAAGCGGTAG CCCGGACGGT GCTGTGGTGC AAGGGCTTGT GGAAAAATTG GAGAAAACCA AGTCCCTGGC CCAGCAGTTG ACAAGGGAGG CCACTCAAGC GGAAATTGAA GCAGATAGGT CTTATCAGCA CAGTCTCCGC CTCCTGGATT CAGTGTCTCG GCTTCAGGGA GTCAGTGATC AGTCCTTTCA GGTGGAAGAA GCAAAGAGGA TCAAACAAAA AGCGGATTCA CTCTCAAGCC TGGTAACCAG GCATATGGAT GAGTTCAAGC GTACACAGAA GAATCTGGGA AACTGGAAAG AAGAAGCACA GCAGCTCTTA CAGAATGGAA AAAGTGGGAG AGAGAAATCA GATCAGCTGC TTTCCCGTGC CAATCTTGCT AAAAGCAGAG CACAAGAAGC ACTGAGTATG GGCAATGCCA CTTTTTATGA AGTTGAGAGC ATCCTTAAAA ACCTCAGAGA GTTTGACCTG CAGGTGGACA ACAGAAAAGC AGAAGCTGAA GAAGCCATGA AGAGACTCTC CTACATCAGC CAGAAGGTTT CAGATGCCAG TGACAAGACC CAGCAAGCAG AAAGAGCCCT GGGGAGCGCT GCTGCTGATG CACAGAGGGC AAAGAATGGG GCCGGGGAGG CCCTGGAAAT CTCCAGTGAG ATTGAACAGG AGATTGGGAG TCTGAACTTG GAAGCCAATG TGACAGCAGA TGGAGCCTTG GCCATGGAAA AGGGACTGGC CTCTCTGAAG AGTGAGATGA GGGAAGTGGA AGGAGAGCTG GAAAGGAAGG AGCTGGAGTT TGACACGAAT ATGGATGCAG TACAGATGGT GATTACAGAA GCCCAGAAGG TTGATACCAG AGCCAAGAAC GCTGGGGTTA CAATCCAAGA CACACTCAAC ACATTAGACG GCCTCCTGCA TCTGATGGGT ATGTGA. It is sometimes possible for the material contained within the vial of "LAMC2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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