KLHL9 cdna clone
KLHL9 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes. [provided by RefSeq, Jul 2016]
Uniprot Description
KLHL9: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
Protein type: Ubiquitin conjugating system; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9p22
Cellular Component: midbody
Molecular Function: ubiquitin-protein ligase activity
Biological Process: cytokinesis; protein ubiquitination
Research Articles on KLHL9
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Product Notes
The KLHL9 klhl9 (Catalog #AAA1270747) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaaagtgt cccttggtaa cggcgaaatg ggcgtctctg cccatttgca gccttgtaag gcaggaacca cacgcttttt taccagcaat actcacagtt cggtggtatt gcaaggcttt gatcagctta gaatagaagg attgctttgt gatgtgaccc tggtaccagg tgatggagat gaaatcttcc ctgttcacag agctatgatg gcgtctgcta gtgattattt caaagccatg ttcacaggtg gaatgaaaga acaagatttg atgtgcatta agcttcatgg ggtgaacaag gttggtctga agaaaatcat tgattttatt tatactgcaa aactttctct taatatggac aatcttcagg acacacttga agctgctagc tttttacaaa tattacccgt tttggatttc tgtaaagtat ttcttatatc aggagtctct ttggataact gtgttgaggt tggacgaatt gctaacacct acaatcttat agaagtggat aaatatgtta ataatttcat cctgaagaac tttcctgctt tattgagtac tggggagttt ctaaaactcc cttttgaacg acttgcattt gtgctttcca gtaatagtct taagcactgt accgaacttg aactctttaa ggcagcctgt cgctggctaa ggttggaaga ccctcggatg gattatgctg caaagttaat gaagaatatt cgatttccac tgatgacacc acaggatctc atcaattacg tgcagacagt agatttcatg agaacagaca atacctgcgt gaatttgctt ttggaagcta gcaattacca aatgatgcca tatatgcagc cagtgatgca gtcagataga actgccattc gatctgactc cactcacttg gttacattag gaggagtttt gaggcagcag ctggttgtca gtaaagaatt acggatgtat gatgaaaggg cacaagaatg gagatcttta gccccaatgg atgctccccg ttaccagcat ggtattgctg tcattggaaa ctttctttat gtagttggtg gtcagagtaa ttatgataca aaaggaaaaa ctgctgttga tacagttttc agatttgatc ctcggtataa taaatggatg caggttgcat cattaaatga aaagcgcaca ttctttcact tgagtgccct caaaggacat ttgtatgcag ttggtgggcg cagtgcagct ggtgaactgg ccacagtaga atgttacaac ccaagaatga atgagtggag ctatgttgca aaaatgagtg aaccccacta tggtcatgct ggaacagtat atggaggctt aatgtatatt tcaggaggaa ttacccatga cactttccaa aatgagctca tgtgttttga cccagataca gataaatgga tgcaaaaggc tccaatgact acagtcagag gtctgcattg catgtgtaca gttggagata agctctatgt cattggtggc aatcacttca gaggaacaag tgattatgat gatgttctaa gctgtgaata ctattcacca acccttgacc agtggacccc aattgccgcc atgttaagag gccaaagtga tgttggagtt gccgtctttg aaaataaaat ctatgttgtt ggtggatatt cttggaataa tcgttgtatg gtagaaattg tccagaaata tgacccagaa aaagatgagt ggcataaagt ttttgatctt ccagagtcac ttggtggcat tcgagcctgt acactcacag tttttccacc tgaagaaaac cctgggtcac cttctagaga atcacctctt tcagcacctt cagatcattc ttag. It is sometimes possible for the material contained within the vial of "KLHL9, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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