KIR2DL4 cdna clone
KIR2DL4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]
Uniprot Description
KIR2DL4: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: protein binding; transmembrane receptor activity
Biological Process: cellular defense response; regulation of immune response; signal transduction
Research Articles on KIR2DL4
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Product Notes
The KIR2DL4 kir2dl4 (Catalog #AAA1274433) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtccatgt cacccacggt catcatcctg gcatgtcttg ggttcttctt ggaccagagt gtgtgggcac acgtgggtgg tcaggacaag cccttctgct ctgcctggcc cagcgctgtg gtgcctcaag gaggacacgt gactcttcgg tgtcactatc gtcgtgggtt taacatcttc acgctgtaca agaaagatgg ggtccctgtc cctgagctct acaacagaat attctggaac agtttcctca ttagccctgt gaccccagca cacgcaggga cctacagatg tcgaggtttt cacccgcact cccccactga gtggtcggca cccagcaacc ccctggtgat catggtcaca ggtctatatg agaaaccttc gcttacagcc cggccgggcc ccacggttcg cacaggagag aacgtgacct tgtcctgcag ctcccagagc tcctttgaca tctaccatct atccagggag ggggaagccc atgaacttag gctccctgca gtgcccagca tcaatggaac attccaggcc gacttccctc tgggtcctgc cacccacgga gagacctaca gatgcttcgg ctctttccat ggatctccct acgagtggtc agacgcgagt gacccactgc ctgtttctgt cacaggaaac ccttctagta gttggccttc acccactgaa ccaagcttca aaactggtat cgccagacac ctgcatgctg tgattaggta ctcagtggcc atcatcctct tcaccatcct tcccttcttt ctccttcatc gctggtgctc caaaaaaaaa aatgctgctg taatgaacca agagcctgcg ggacacagaa cagtgaacag ggaggactct gatgaacaag accctcagga ggtgacatac gcacagttgg atcactgcat tttcacacag agaaaaatca ctggcccttc tcagaggagc aagagaccct caacagatac cagcgtgtgt atagaacttc caaatgctga gcccagagcg ttatctcctg cccatgagca ccacagtcag gccttgatgg gatcttctag ggagacaaca gccctgtctc aaacccagct tgccagctct aatgtaccag cagctggaat ctga. It is sometimes possible for the material contained within the vial of "KIR2DL4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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