Test Data
KCND3 cdna clone
KCND3 cDNA Clone
Test Data
Test Data
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: plasma membrane; voltage-gated potassium channel complex
Molecular Function: A-type (transient outward) potassium channel activity; delayed rectifier potassium channel activity; protein binding
Biological Process: potassium ion transport
Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19
Research Articles on KCND3
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Product Notes
The KCND3 kcnd3 (Catalog #AAA1266938) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGGCCG GAGTTGCGGC CTGGCTGCCT TTTGCCCGGG CTGCGGCCAT CGGGTGGATG CCGGTGGCCA ACTGCCCCAT GCCCCTGGCC CCGGCCGACA AGAACAAGCG GCAGGATGAG CTGATTGTCC TCAACGTGAG TGGGCGGAGG TTCCAGACCT GGAGGACCAC GCTGGAGCGC TACCCGGACA CCCTGCTGGG CAGCACGGAG AAGGAGTTCT TCTTCAACGA GGACACCAAG GAGTACTTCT TCGACCGGGA CCCCGAGGTG TTCCGCTGCG TGCTCAACTT CTACCGCACG GGGAAGCTGC ACTACCCGCG CTACGAGTGC ATCTCTGCCT ACGACGACGA GCTGGCCTTC TACGGCATCC TCCCGGAGAT CATCGGGGAC TGCTGCTACG AGGAGTACAA GGACCGCAAG AGGGAGAACG CCGAGCGGCT CATGGACGAC AACGACTCGG AGAACAACCA GGAGTCCATG CCCTCGCTCA GCTTCCGCCA GACCATGTGG CGGGCCTTCG AGAACCCCCA CACCAGCACG CTGGCCCTGG TCTTCTACTA CGTGACTGGC TTCTTCATCG CTGTCTCGGT CATCACCAAC GTGGTGGAGA CGGTGCCGTG CGGCACGGTC CCGGGCAGCA AGGAGCTGCC GTGCGGGGAG CGCTACTCGG TGGCCTTCTT CTGCCTGGAC ACGGCGTGCG TCATGATCTT CACCGTGGAG TACCTCCTGC GGCTCTTCGC GGCTCCCAGC CGCTACCGCT TCATCCGCAG CGTCATGAGC ATCATCGACG TGGTGGCCAT CATGCCCTAC TACATCGGTC TGGTCATGAC CAACAACGAG GACGTGTCCG GCGCCTTCGT CACGCTCCGG GTCTTCCGCG TCTTCAGGAT CTTCAAGTTT TCCCGCCACT CCCAGGGCCT GCGGATCCTG GGCTACACAC TGAAGAGCTG TGCCTCCGAA CTGGGCTTTC TTCTCTTCTC CCTCACCATG GCCATCATCA TCTTTGCCAC TGTGATGTTT TATGCCGAGA AGGGCTCCTC GGCCAGCAAG TTCACAAGCA TCCCTGCCTC GTTTTGGTAC ACCATTGTCA CCATGACCAC ACTGGGATAC GGAGACATGG TTCCTAAGAC GATTGCAGGG AAGATCTTCG GCTCCATCTG CTCCTTGAGT GGCGTCCTGG TCATTGCCCT GCCAGTCCCT GTGATTGTTT CCAACTTTAG CCGGATTTAC CACCAGAATC AGAGAGCTGA TAAACGCAGG GCACAAAAGA AGGCCCGCCT TGCCAGGATC CGTGTGGCCA AAACAGGCAG TTCGAATGCA TACCTGCACA GCAAGCGCAA CGGGCTCCTC AACGAGGCGC TGGAGCTGAC GGGCACCCCA GAAGAGGAGC ACATGGGCAA GACCACCTCA CTCATCGAGA GCCAGCATCA TCACCTGCTG CACTGCCTGG AAAAAACCAC TAACCACGAG TTTATTGATG AGCAGATGTT TGAGCAGAAC TGCATGGAGA GTTCAATGCA GAACTACCCA TCCACAAGAA GTCCCTCACT GTCCAGCCAC CCAGGCCTCA CTACCACCTG CTGCTCCCGT CGTAGTAAGA AGACCACACA CCTGCCCAAT TCTAACCTGC CAGCTACTCG CCTGCGCAGC ATGCAAGAGC TCAGCACGAT CCACATCCAG GGCAGTGAGC AGCCCTCCCT CACAACCAGT CGCTCCAGCC TTAATTTGAA AGCAGACGAC GGACTGAGAC CAAACTGCAA AACATCCCAG ATCACCACAG CCATCATCAG CATCCCCACT CCCCCAGCGC TAACCCCAGA GGGGGAAAGT CGGCCACCCC CTGCCAGCCC AGGCCCCAAC ACGAACATTC CTTCCATAGC CAGCAATGTT GTCAAGGTCT CCGCCTTGTA A. It is sometimes possible for the material contained within the vial of "KCND3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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