IL2RG cdna clone
IL2RG cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Uniprot Description
IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: external side of plasma membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: interleukin-2 binding; interleukin-2 receptor activity; interleukin-4 receptor activity; interleukin-7 receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: immune response; MAPKKK cascade
Disease: Combined Immunodeficiency, X-linked; Severe Combined Immunodeficiency, X-linked
Research Articles on IL2RG
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Product Notes
The IL2RG il2rg (Catalog #AAA1268469) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgttgaagc catcattacc attcacatcc ctcttattcc tgcagctgcc cctgctggga gtggggctga acacgacaat tctgacgccc aatgggaatg aagacaccac agctgatttc ttcctgacca ctatgcccac tgactccctc agtgtttcca ctctgcccct cccagaggtt cagtgttttg tgttcaatgt cgagtacatg aattgcactt ggaacagcag ctctgagccc cagcctacca acctcactct gcattattgg tacaagaact cggataatga taaagtccag aagtgcagcc actatctatt ctctgaagaa atcacttctg gctgtcagtt gcaaaaaaag gagatccacc tctaccaaac atttgttgtt cagctccagg acccacggga acccaggaga caggccacac agatgctaaa actgcagaat ctggtgatcc cctgggctcc agagaaccta acacttcaca aactgagtga atcccagcta gaactgaact ggaacaacag attcttgaac cactgtttgg agcacttggt gcagtaccgg actgactggg accacagctg gactgaacaa tcagtggatt atagacataa gttctccttg cctagtgtgg atgggcagaa acgctacacg tttcgtgttc ggagccgctt taacccactc tgtggaagtg ctcagcattg gagtgaatgg agccacccaa tccactgggg gagcaatact tcaaaagaga atcctttcct gtttgcattg gaagccgtgg ttatctctgt tggctccatg ggattgatta tcagccttct ctgtgtgtat ttctggctgg aacggacgat gccccgaatt cccaccctga agaacctaga ggatcttgtt actgaatacc acgggaactt ttcggcctgg agtggtgtgt ctaagggact ggctgagagt ctgcagccag actacagtga acgactctgc ctcgtcagtg agattccccc aaaaggaggg gcccttgggg aggggcctgg ggcctcccca tgcaaccagc atagccccta ctgggccccc ccatgttaca ccctaaagcc tgaaacctga. It is sometimes possible for the material contained within the vial of "IL2RG, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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