IDE cdna clone
IDE cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
Uniprot Description
IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Nuclear receptor co-regulator; EC 3.4.24.56; Cell surface
Chromosomal Location of Human Ortholog: 10q23-q25
Cellular Component: cell surface; cytoplasm; cytosol; extracellular space; mitochondrion; nucleoplasm; nucleus; peroxisomal matrix; peroxisome
Molecular Function: ATP binding; glycoprotein binding; insulin binding; metalloendopeptidase activity; peptide binding; protein binding; protein homodimerization activity; receptor binding; ubiquitin binding; zinc ion binding
Biological Process: beta-amyloid metabolic process; determination of adult life span; positive regulation of protein oligomerization; protein homooligomerization; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process
Research Articles on IDE
Similar Products
Product Notes
The IDE ide (Catalog #AAA1276552) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCGGTACC GGCTAGCGTG GCTTCTGCAC CCCGCACTGC CCAGCACCTT CCGCTCAGTC CTCGGCGCCC GCCTGCCGCC TCCGGAGCGC CTGTGTGGTT TCCAAAAAAA GACTTACAGC AAAATGAATA ATCCAGCCAT CAAGAGAATA GGAAATCACA TTACCAAGTC TCCTGAAGAC AAGCGAGAAT ATCGAGGGCT AGAGCTGGCC AATGGTATCA AAGTACTTCT TATCAGTGAT CCCACCACGG ATAAGTCATC AGCAGCACTT GATGTGCACA TAGGTTCATT GTCGGATCCT CCAAATATTG CTGGCTTAAG TCATTTTTGT GAACATATGC TTTTTTTGGG AACAAAGAAA TACCCTAAAG AAAATGAATA CAGCCAGTTT CTCAGTGAGC ATGCAGGAAG TTCAAATGCC TTTACTAGTG GAGAGCATAC CAATTACTAT TTTGATGTTT CTCATGAACA CCTAGAAGGT GCCCTAGACA GGTTTGCACA GTTTTTTCTG TGCCCCTTGT TCGATGAAAG TTGCAAAGAC AGAGAGGTGA ATGCAGTTGA TTCAGAACAT GAGAAGAATG TGATGAATGA TGCCTGGAGA CTCTTTCAAT TGGAAAAAGC TACAGGGAAT CCTAAACACC CCTTCAGTAA ATTTGGGACA GGTAACAAAT ATACTCTGGA GACTAGACCA AACCAAGAAG GCATTGATGT AAGACAAGAG CTACTGAAAT TCCATTCTGC TTACTATTCA TCCAACTTAA TGGCTGTTTG TGTTTTAGGT CGAGAATCTT TAGATGACTT GACTAATCTG GTGGTAAAGT TATTTTCTGA AGTAGAGAAC AAAAATGTTC CATTGCCAGA ATTTCCTGAA CACCCTTTCC AAGAAGAACA TCTTAAACAA CTTTACAAAA TAGTACCCAT TAAAGATATT AGGAATCTCT ATGTGACATT TCCCATACCT GACCTTCAGA AATACTACAA ATCAAATCCT GGTCATTATC TTGGTCATCT CATTGGGCAT GAAGGTCCTG GAAGTCTGTT ATCAGAACTT AAGTCAAAGG GCTGGGTTAA TACTCTTGTT GGTGGGCAGA AGGAAGGAGC CCGAGGTTTT ATGTTTTTTA TCATTAATGT GGACTTGACC GAGGAAGGAT TATTACATGT TGAAGATATA ATTTTGCACA TGTTTCAATA CATTCAGAAG TTACGTGCAG AAGGACCTCA AGAATGGGTT TTCCAAGAGT GCAAGGACTT GAATGCTGTT GCTTTTAGGT TTAAAGACAA AGAGAGGCCA CGGGGCTATA CATCTAAGAT TGCAGGAATA TTGCATTATT ATCCCCTAGA AGAGGTGCTC ACAGCGGAAT ATTTACTGGA AGAATTTAGA CCTGACTTAA TAGAGATGGT TCTCGATAAA CTCAGACCAG AAAATGTCCG GGTTGCCATA GTTTCTAAAT CTTTTGAAGG AAAAACTGAT CGCACAGAAG AGTGGTATGG AACCCAGTAC AAACAAGAAG CTATACCGGA TGAAGTCATC AAGAAATGGC AAAATGCTGA CCTGAATGGG AAATTTAAAC TTCCTACAAA GAATGAATTT ATTCCTACGA ATTTTGAGAT TTTACCGTTA GAAAAAGAGG CGACACCATA CCCTGCTCTT ATTAAGGATA CAGCTATGAG CAAACTTTGG TTCAAACAAG ATGATAAGTT TTTTTTGCCG AAGGCTTGTC TCAACTTTGA ATTTTTCAGC CCATTTGCTT ATGTGGACCC CTTGCACTGT AACATGGCCT ATTTGTACCT TGAGCTCCTC AAAGACTCAC TCAACGAGTA TGCATATGCA GCAGAGCTAG CAGGCTTGAG CTATGATCTC CAAAATACCA TCTATGGGAT GTATCTTTCA GTGAAAGGTT ACAATGACAA GCAGCCAATT TTACTAAAGA AGATTATTGA GAAAATGGCT ACCTTTGAGA TTGATGAAAA AAGATTTGAA ATTATCAAAG AAGCATATAT GCGATCTCTT AACAATTTCC GGGCTGAACA GCCTCACCAG CATGCCATGT ACTACCTCCG CTTGCTGATG ACTGAAGTGG CCTGGACTAA AGATGAGTTA AAAGAAGCTC TGGATGATGT AACCCTTCCT CGCCTTAAGG CCTTCATACC TCAGCTCCTG TCACGGCTGC ACATTGAAGC CCTTCTCCAT GGAAACATAA CAAAGCAGGC TGCATTAGGA ATTATGCAGA TGGTTGAAGA CACCCTCATT GAACATGCTC ATACCAAACC TCTCCTTCCA AGTCAGCTGG TTCGGTATAG AGAAGTTCAG CTCCCTGACA GAGGATGGTT TGTTTATCAG CAGAGAAATG AAGTTCACAA TAACTGTGGC ATCGAGATAT ACTACCAAAC AGACATGCAA AGCACCTCAG AGAATATGTT TCTGGAGCTC TTCTGTCAGA TTATCTCGGA ACCTTGCTTC AACACCCTGC GCACCAAGGA GCAGTTGGGC TATATCGTCT TCAGCGGGCC ACGTCGAGCT AATGGCATAC AGGGCTTGAG ATTCATCATC CAGTCAGAAA AGCCACCTCA CTACCTAGAA AGCAGAGTGG AAGCTTTCTT AATTACCATG GAAAAGTCCA TAGAGGACAT GACAGAAGAG GCCTTCCAAA AACACATTCA GGCATTAGCA ATTCGTCGAC TAGACAAACC AAAGAAGCTA TCTGCTGAGT GTGCTAAATA CTGGGGAGAA ATCATCTCCC AGCAATATAA TTTTGACAGA GATAACACTG AGGTTGCATA TTTAAAGACA CTTACCAAGG AAGATATCAT CAAATTCTAC AAGGAAATGT TGGCAGTAGA TGCTCCAAGG AGACATAAGG TATCCGTCCA TGTTCTTGCC AGGGAAATGG ATTCTTGTCC TGTTGTTGGA GAGTTCCCAT GTCAAAATGA CATAAATTTG TCACAAGCAC CAGCCTTGCC ACAACCTGAA GTGATTCAGA ACATGACCGA ATTCAAGCGT GGTCTGCCAC TGTTTCCCCT TGTGAAACCA CATATTAACT TCATGGCTGC AAAACTCTGA. It is sometimes possible for the material contained within the vial of "IDE, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
