HTR3A cdna clone
HTR3A cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, cation; Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; plasma membrane
Molecular Function: acetylcholine binding; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; protein binding; serotonin binding; serotonin-activated cation-selective channel activity; serotonin-gated cation channel activity
Biological Process: synaptic transmission, cholinergic
Research Articles on HTR3A
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Product Notes
The HTR3A htr3a (Catalog #AAA1277625) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgctgctgt gggtccagca ggcgctgctc gccttgctcc tccccacact cctggcacag ggagaagcca ggaggagccg aaacaccacc aggcccgctc tgctgaggct gtcggattac cttttgacca actacaggaa gggtgtgcgc cccgtgaggg actggaggaa gccaaccacc gtatccattg acgtcattgt ctatgccatc ctcaacgtgg atgagaagaa tcaggtgctg accacctaca tctggtaccg gcagtactgg actgatgagt ttctccagtg gaaccctgag gactttgaca acatcaccaa gttgtccatc cccacggaca gcatctgggt cccggacatt ctcatcaatg agttcgtgga tgtggggaag tctccaaata tcccgtacgt gtatattcgg catcaaggcg aagttcagaa ctacaagccc cttcaggtgg tgactgcctg tagcctcgac atctacaact tccccttcga tgtccagaac tgctcgctga ccttcaccag ttggctgcac accatccagg acatcaacat ctctttgtgg cgcttgccag aaaaggtgaa atccgacagg agtgtcttca tgaaccaggg agagtgggag ttgctggggg tgctgcccta ctttcgggag ttcagcatgg aaagcagtaa ctactatgca gaaatgaagt tctatgtggt catccgccgg cggcccctct tctatgtggt cagcctgcta ctgcccagca tcttcctcat ggtcatggac atcgtgggct tctacctgcc ccccaacagt ggcgagaggg tctctttcaa gattacactc ctcctgggct actcggtctt cctgatcatc gtttctgaca cgctgccggc cactgccatc ggcactcctc tcattggtgt ctactttgtg gtgtgcatgg ctctgctggt gataagtttg gccgagacca tcttcattgt gcggctggtg cacaagcaag acctgcagca gcccgtgcct gcttggctgc gtcacctggt tctggagaga atcgcctggc tactttgcct gagggagcag tcaacttccc agaggccccc agccacctcc caagccacca agactgatga ctgctcagcc atgggaaacc actgcagcca catgggagga ccccaggact tcgagaagag cccgagggac agatgtagcc ctcccccacc acctcgggag gcctcgctgg cggtgtgtgg gctgctgcag gagctgtcct ccatccggca attcctggaa aagcgggatg agatccgaga ggtggcccga gactggctgc gcgtgggctc cgtgctggac aagctgctat tccacattta cctgctggcg gtgctggcct acagcatcac cctggttatg ctctggtcca tctggcagta cgcttga. It is sometimes possible for the material contained within the vial of "HTR3A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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