HSPA8 cdna clone
HSPA8 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
HSC70: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Chaperone; RNA-binding; Nucleolus; Heat shock protein
Chromosomal Location of Human Ortholog: 11q24.1
Cellular Component: cell-cell adherens junction; cytosol; extracellular matrix; extracellular space; focal adhesion; intracellular; lysosomal lumen; lysosomal membrane; membrane; nucleoplasm; nucleus; plasma membrane; ribonucleoprotein complex; ubiquitin ligase complex
Molecular Function: ATP binding; ATPase activity; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process: ATP metabolic process; cellular response to starvation; negative regulation of transcription, DNA-dependent; neurotransmitter secretion; nuclear mRNA splicing, via spliceosome; protein refolding; protein targeting to lysosome; regulation of mRNA stability; regulation of protein complex assembly; regulation of protein stability
Research Articles on HSPA8
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Product Notes
The HSPA8 hspa8 (Catalog #AAA1278065) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtccaagg gacctgcagt tggtattgat cttggcacca cctactcttg tgtgggtgtt ttccagcacg gaaaagtcga gataattgcc aatgatcagg gaaaccgaac cactccaagc tatgtcgcct ttacggacac tgaacggttg atcggtgatg ccgcaaagaa tcaagttgca atgaacccca ccaacacagt ttttgatgcc aaacgtctga ttggacgcag atttgatgat gctgttgtcc agtctgatat gaaacattgg ccctttatgg tggtgaatga tgctggcagg cccaaggtcc aagtagaata caagggagag accaaaagct tctatccaga ggaggtgtct tctatggttc tgacaaagat gaaggaaatt gcagaagcct accttgggaa gactgttacc aatgctgtgg tcacagtgcc agcttacttt aatgactctc agcgtcaggc taccaaagat gctggaacta ttgctggtct caatgtactt agaattatta atgagccaac tgctgctgct attgcttacg gcttagacaa aaaggttgga gcagaaagaa acgtgctcat ctttgacctg ggaggtggca cttttgatgt gtcaatcctc actattgagg atggaatctt tgaggtcaag tctacagctg gagacaccca cttgggtgga gaagattttg acaaccgaat ggtcaaccat tttattgctg agtttaagcg caagcataag aaggacatca gtgagaacaa gagagctgta agacgcctcc gtactgcttg tgaacgtgct aagcgtaccc tctcttccag cacccaggcc agtattgaga tcgattctct ctatgaagga atcgacttct atacctccat tacccgtgcc cgatttgaag aactgaatgc tgacctgttc cgtggcaccc tggacccagt agagaaagcc cttcgagatg ccaaactaga caagtcacag attcatgata ttgtcctggt tggtggttct actcgtatcc ccaagattca gaagcttctc caagacttct tcaatggaaa agaactgaat aagagcatca accctgatga agctgttgct tatggtgcag ctgtccaggc agccatcttg tctggagaca agtctgagaa tgttcaagat ttgctgctct tggatgtcac tcctctttcc cttggtattg aaactgctgg tggagtcatg actgtcctca tcaagcgtaa taccaccatt cctaccaagc agacacagac cttcactacc tattctgaca accagcctgg tgtgcttatt caggtttatg aaggcgagcg tgccatgaca aaggataaca acctgcttgg caagtttgaa ctcacaggca tacctcctgc accccgaggt gttcctcaga ttgaagtcac ttttgacatt gatgccaatg gtatactcaa tgtctctgct gtggacaaga gtacgggaaa agagaacaag attactatca ctaatgacaa gggccgtttg agcaaggaag acattgaacg tatggtccag gaagctgaga agtacaaagc tgaagatgag aagcagaggg acaaggtgtc atccaagaat tcacttgagt cctatgcctt caacatgaaa gcaactgttg aagatgagaa acttcaaggc aagattaacg atgaggacaa acagaagatt ctggacaagt gtaatgaaat tatcaactgg cttgataaga atcagactgc tgagaaggaa gaatttgaac atcaacagaa agagctggag aaagtttgca accccatcat caccaagctg taccagagtg caggaggcat gccaggagga atgcctgggg gatttcctgg tggtggagct cctccctctg gtggtgcttc ctcagggccc accattgaag aggttgatta a. It is sometimes possible for the material contained within the vial of "HSPA8, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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