GPBAR1 cdna clone
GPBAR1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Description
GPBAR1: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cytoplasm; plasma membrane
Research Articles on GPBAR1
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Product Notes
The GPBAR1 gpbar1 (Catalog #AAA1266426) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgacgccca acagcactgg cgaggtgccc agccccattc ccaagggggc tttggggctc tccctggccc tggcaagcct catcatcacc gcgaacctgc tcctagccct gggcatcgcc tgggaccgcc gcctgcgcag cccacctgct ggctgcttct tcctgagcct actgctggct gggctgctca cgggtctggc attgcccaca ttgccagggc tgtggaacca gagtcgccgg ggttactggt cctgcctcct cgtctacttg gctcccaact tctccttcct ctccctgctt gccaacctct tgctggtgca cggggagcgc tacatggcag tcctgaggcc actccagccc cctgggagca ttcggctggc cctgctcctc acctgggctg gtcccctgct ctttgccagt ctgcccgctc tggggtggaa ccactggacc cctggtgcca actgcagctc ccaggctatc ttcccagccc cctacctgta cctcgaagtc tatgggctcc tgctgcccgc cgtgggtgct gctgccttcc tctctgtccg cgtgctggcc actgcccacc gccagctgca ggacatctgc cggctggagc gggcagtgtg ccgcgatgag ccctccgccc tggcccgggc ccttacctgg aggcaggcaa gggcacaggc tggagccatg ctgctcttcg ggctgtgctg ggggccctac gtggccacac tgctcctctc agtcctggcc tatgagcagc gcccgccact ggggcctggg acactgttgt ccctcctctc cctaggaagt gccagtgcag cggcagtgcc cgtagccatg gggctgggcg atcagcgcta cacagccccc tggagggcag ccgcccaaag gtgcctgcag gggctgtggg gaagagcctc ccgggacagt cccggcccca gcattgccta ccacccaagc agccaaagca gtgtcgacct ggacttgaac taa. It is sometimes possible for the material contained within the vial of "GPBAR1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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