GIT2 cdna clone
GIT2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Uniprot Description
GIT2: possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Regulates Golgi and actin cytoskeletal organization. Important in integrin-mediated cell adhesion. Ten alternatively spliced isoforms have been described and additional isoforms seem to exist. Contains 1 Arf-GAP domain and 3 ANK repeats.
Protein type: GAPs, ARF; Motility/polarity/chemotaxis; GAPs
Chromosomal Location of Human Ortholog: 12q24.1
Cellular Component: focal adhesion; nucleoplasm
Molecular Function: protein binding
Biological Process: regulation of G-protein coupled receptor protein signaling pathway
Research Articles on GIT2
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Product Notes
The GIT2 git2 (Catalog #AAA1270251) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgagtggaa gacgtaaagc taatccacag gataaagtac atcccaataa agcggaattc atcagagcca agtatcagat gttagcgttc gtccatcgct tgccctgccg ggatgacgat agtgtgactg ccaaagatct tagcaagcaa ctccattcga gcgtgagaac agggaatctt gaaacctgtt tgagactgtt atctttagga gcacaagcca acttctttca tcctgaaaaa ggaaacaccc cactccatgt tgcctccaaa gcagggcaga ttttacaggc tgaattattg gcagtatatg gagcagaccc aggcacacag gattctagtg ggaaaactcc cgttgattat gcaaggcaag gagggcacca tgagctggca gagcgcctcg tggaaataca gtatgagcta acggacagac tagccttcta tctctgtggc aggaaaccag atcacaaaaa tggacagcac tttataatac ctcaaatggc agacagcagc ctggatttgt ctgaattggc aaaagctgct aagaagaaac ttcaatctct aagtaatcat ttgtttgaag aacttgccat ggatgtgtac gatgaagttg acaggcgaga gacggatgca gtctggcttg ccacgcaaaa ccacagcgcc ctggtaaccg agacaacggt cgtccccttt cttccggtca atcctgagta ctcatcaaca cgaaatcagg gcagacagaa gttagctcgg ttcaacgccc atgagtttgc cacgctggtc attgacattc tcagtgacgc caagaggaga cagcagggca gttctctctc gggttcaaaa gacaatgtgg agctcatact gaaaaccatc aataaccagc acagcgttga gagtcaagac aacgatcagc ccgactatga cagcgtggca tcagacgaag acacagattt ggaaaccact gcaagcaaaa caaaccggca gaagagccta gattcagatt tatcagatgg accagtcact gtacaggaat ttatggaggt caaaaacgct ctagtggctt ctgaggccaa gatacagcag ctaatgaagg catccaggct ggagaagcag aacagcacac ctgagagtga ctacgacaac actcccaacg acatggagcc agatggcatg gggtcaagcc gaaagggacg gcaaagaagt atggtgtggc caggggatgg cttggtacca gacacagcag aaccccatgt ggccccaagc cccactctcc ctagcaccga agatgtcatc aggaagactg aacagatcac caaaaacata caggagctct taagagcagc ccaagaaaat aaacatgaca gttatattcc ctgctcagag aggatacacg tagctgttac agaaatggca gcattattcc ccaaaaaacc caagtctgat atggtgagga cttcccttcg tttactgacg tccagtgcct accgactgca gtcagagtgc aagaagaccc tcccagggga ccccggctca cccacagacg ttcagctggt cacgcagcag gtcatccagt gtgcgtacga catcgccaag gctgccaagc agctggttac catcaccacc aaagagaaca acaactga. It is sometimes possible for the material contained within the vial of "GIT2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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