GADD45GIP1 cdna clone
GADD45GIP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
Uniprot Description
GADD45GIP1: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Down-regulated by p53/TP53 in apoptotic cells. Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: protein binding
Research Articles on GADD45GIP1
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Product Notes
The GADD45GIP1 gadd45gip1 (Catalog #AAA1270427) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggcgt ccgtgcgaca ggcacgcagc ctactaggtg tggcggcgac cctggccccg ggttcccgtg gctaccgggc gcggccgccc ccgcgccgca ggccgggacc ccggtggcca gaccccgagg acctcctgac cccgcggtgg cagctgggac cgcgctacgc ggctaagcag ttcgcgcgtt acggcgccgc ctccggggtg gtccccggtt cgttatggcc gtcgccggag cagctgcggg agctggaggc cgaagaacgc gaatggtacc cgagcctggc gaccatgcag gagtcgctgc gggtgaagca gctggccgaa gagcagaagc gtcgggagag ggagcagcac atcgcagagt gcatggccaa gatgccacag atgattgtga actggcagca gcagcagcgg gagaactggg agaaggccca ggctgacaag gagaggaggg cccgactgca ggctgaggcc caggagctcc tgggctacca ggtggaccca aggagtgccc gcttccagga gctgctccag gacctagaga agaaggagcg caagcgcctc aaggaggaaa aacagaaacg gaagaaggag gcgcgagctg ctgcattggc tgcagctgtg gctcaagacc cagcagcctc tggggcaccc agctcctga. It is sometimes possible for the material contained within the vial of "GADD45GIP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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