FZR1 cdna clone
FZR1 cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
FZR1: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1- mediated APC/C activation. Interacts with USP37. Interacts (via WD repeats) with MAK. Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. Belongs to the WD repeat CDC20/Fizzy family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: anaphase-promoting complex; cytosol; nuclear membrane; nucleoplasm
Molecular Function: protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition DNA damage checkpoint; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Research Articles on FZR1
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Product Notes
The FZR1 fzr1 (Catalog #AAA1266671) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggaccagg actatgagcg gcgcctgctt cgccagatcg tcatccagaa tgagaacacg atgccacgcg tcacagagat gcggcggacc ctgacgcctg ccagctcccc agtgtcctcg cccagcaagc acggagaccg cttcatcccc tccagagccg gagccaactg gagcgtgaac ttccacagga ttaacgagaa tgagaagtct cccagtcaga accggaaagc caaggacgcc acctcagaca acggcaaaga cggcctggcc tactctgccc tgctcaagaa tgagctgctg ggtgccggca tcgagaaggt gcaggacccg cagactgagg accgcaggct gcagccctcc acgcctgaga agaagggtct gttcacgtat tcccttagca ccaagcgctc cagccccgat gacggcaacg atgtgtctcc ctactccctg tctcccgtca gcaacaagag ccagaagctg ctccggtccc cccggaaacc cacccgcaag atctccaaga tccccttcaa ggtgctggac gcgcccgagc tgcaggacga cttctacctc aatctggtgg actggtcgtc cctcaatgtg ctcagcgtgg ggctaggcac ctgcgtgtac ctgtggagtg cctgtaccag ccaggtgacg cggctctgtg acctctcagt ggaaggggac tcagtgacct ccgtgggctg gtctgagcgg gggaacctgg tggcggtggg cacacacaag ggcttcgtgc agatctggga cgcagccgca gggaagaagc tgtccatgtt ggagggccac acggcacgcg tcggggcgct ggcctggaat gctgagcagc tgtcgtccgg gagccgcgac cgcatgatcc tgcagaggga catccgcacc ccgccactgc agtcggagcg gcggctgcag ggccaccggc aggaggtgtg cgggctcaag tggtccacag accaccagct cctcgcctcg gggggcaacg acaacaagct gctggtctgg aatcactcga gcctgagccc cgtgcagcag tacacggagc acctggcggc cgtgaaggcc atcgcctggt ccccacatca gcacgggctg ctggcctcgg ggggcggcac agctgaccgc tgtatccgct tctggaacac gctgacagga caaccactgc agtgtatcga cacgggctcc caagtgtgca atctggcctg gtccaagcac gccaacgagc tggtgagcac gcacggctac tcacagaacc agatccttgt ctggaagtac ccctccctga cccaggtggc caagctgacc gggcactcct accgcgtgct gtacctggca atgtcccctg atggggaggc catcgtcact ggtgctggag acgagaccct gaggttctgg aacgtcttta gcaaaacccg ttcgacaaag gagtctgtgt ctgtgctcaa cctcttcacc aggatccggt aa. It is sometimes possible for the material contained within the vial of "FZR1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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