Test Data
FOXP3 cdna clone
FOXP3 cDNA Clone
Test Data
Test Data
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; DNA-binding; C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: cytoplasm; nucleus
Molecular Function: histone acetyltransferase binding; histone deacetylase binding; NFAT protein binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; inhibition of CREB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of cell proliferation; negative regulation of cytokine biosynthetic process; negative regulation of cytokine secretion; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of T cell anergy; response to virus; T cell activation
Disease: Diabetes Mellitus, Insulin-dependent; Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-linked
Research Articles on FOXP3
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Product Notes
The FOXP3 foxp3 (Catalog #AAA1269190) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCCCAACC CCAGGCCTGG CAAGCCCTCG GCCCCTTCCT TGGCCCTTGG CCCATCCCCA GGAGCCTCGC CCAGCTGGAG GGCTGCACCC AAAGCCTCAG ACCTGCTGGG GGCCCGGGGC CCAGGGGGAA CCTTCCAGGG CCGAGATCTT CGAGGCGGGG CCCATGCCTC CTCTTCTTCC TTGAACCCCA TGCCACCATC GCAGCTGCAG CTGCCCACAC TGCCCCTAGT CATGGTGGCA CCCTCCGGGG CACGGCTGGG CCCCTTGCCC CACTTACAGG CACTCCTCCA GGACAGGCCA CATTTCATGC ACCAGCTCTC AACGGTGGAT GCCCACGCCC GGACCCCTGT GCTGCAGGTG CACCCCCTGG AGAGCCCAGC CATGATCAGC CTCACACCAC CCACCACCGC CACTGGGGTC TTCTCCCTCA AGGCCCGGCC TGGCCTCCCA CCTGGGATCA ACGTGGCCAG CCTGGAATGG GTGTCCAGGG AGCCGGCACT GCTCTGCACC TTCCCAAATC CCAGTGCACC CAGGAAGGAC AGCACCCTTT CGGCTGTGCC CCAGAGCTCC TACCCACTGC TGGCAAATGG TGTCTGCAAG TGGCCCGGAT GTGAGAAGGT CTTCGAAGAG CCAGAGGACT TCCTCAAGCA CTGCCAGGCG GACCATCTTC TGGATGAGAA GGGCAGGGCA CAATGTCTCC TCCAGAGAGA GATGGTACAG TCTCTGGAGC AGCAGCTGGT GCTGGAGAAG GAGAAGCTGA GTGCCATGCA GGCCCACCTG GCTGGGAAAA TGGCACTGAC CAAGGCTTCA TCTGTGGCAT CATCCGACAA GGGCTCCTGC TGCATCGTAG CTGCTGGCAG CCAAGGCCCT GTCGTCCCAG CCTGGTCTGG CCCCCGGGAG GCCCCTGACA GCCTGTTTGC TGTCCGGAGG CACCTGTGGG GTAGCCATGG AAACAGCACA TTCCCAGAGT TCCTCCACAA CATGGACTAC TTCAAGTTCC ACAACATGCG ACCCCCTTTC ACCTACGCCA CGCTCATCCG CTGGGCCATC CTGGAGGCTC CAGAGAAGCA GCGGACACTC AATGAGATCT ACCACTGGTT CACACGCATG TTTGCCTTCT TCAGAAACCA TCCTGCCACC TGGAAGAACG CCATCCGCCA CAACCTGAGT CTGCACAAGT GCTTTGTGCG GGTGGAGAGC GAGAAGGGGG CTGTGTGGAC CGTGGATGAG CTGGAGTTCC GCAAGAAACG GAGCCAGAGG CCCAGCAGGT GTTCCAACCC TACACCTGGC CCCTGA. It is sometimes possible for the material contained within the vial of "FOXP3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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