FIP1L1 cdna clone
FIP1L1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Uniprot Description
FIP1L1: a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA) is the cause of some cases of hypereosinophilic syndrome (HES), a disorder characterized by overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage. Four alternatively spliced isoforms have been described.
Protein type: RNA-binding; RNA processing
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: nucleoplasm
Molecular Function: protein binding
Biological Process: mRNA 3'-end processing; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; termination of RNA polymerase II transcription
Disease: Hypereosinophilic Syndrome, Idiopathic
Research Articles on FIP1L1
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Product Notes
The FIP1L1 fip1l1 (Catalog #AAA1267163) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGATCACTT CAGATTTTCA TAATACTAGT TTCTTTAAGA GTGGTTTCTT TATTTTGTTT GCTTATTTAT TTATTTGTTT ATTTTACTTG GTAGATGAAA ATGAAGTTGA AAGGCCAGAA GAAGAAAATG CCAGTGCTAA TCCTCCATCT GGAATTGAAG ATGAAACTGC TGAAAATGGT GTACCAAAAC CGAAAGTGAC TGAGACCGAA GATGATAGTG ATAGTGACAG CGATGATGAT GAAGATGATG TTCATGTCAC TATAGGAGAC ATTAAAACGG GAGCACCACA GTATGGGAGT TATGGTACAG CACCTGTAAA TCTTAACATC AAGACAGGGG GAAGAGTTTA TGGAACTACA GGGACAAAAG TCAAAGGAGT AGACCTTGAT GCACCTGGAA GCATTAATGG AGTTCCACTC TTAGAGGTAG ATTTGGATTC TTTTGAAGAT AAACCATGGC GTAAACCTGG TGCTGATCTT TCTGATTATT TTAATTATGG GTTTAATGAA GATACCTGGA AAGCTTACTG TGAAAAACAA AAGAGGATAC GAATGGGACT TGAAGTTATA CCAGTAACCT CTACTACAAA TAAAATTACG GTACAGCAGG GAAGAACTGG AAACTCAGAG AAAGAAACTG CCCTTCCATC TACAAAAGCT GAGTTTACTT CTCCTCCTTC TTTGTTCAAG ACTGGGCTTC CACCGAGCAG AAACAGCACT TCTTCTCAGT CTCAGACAAG TACTGCCTCC AGAAAAGCCA ATTCAAGCGT TGGGAAGTGG CAGGATCGAT ATGGGAGGGC CGAATCACCT GATCTAAGGA GATTACCTAG GGCAATTGAT GTTATCGGTC AGACTATAAC TATCAGCCGA GTAGAAGGCA GGCGACGGGC AAATGAGAAC AGCAACATAC AGGTCCTTTC TGAAAGATCT GCTACTGAAG TAGACAACAA TTTTAGCAAA CCACCTCCGT TTTTCCCTCC AGGAGCTCCT CCCACTCACC TTCCACCTCC TCCATTTCTT CCACCTCCTC CGACTGTCAG CACTGCTCCA CCTCTGATTC CACCACCGGG TTTTCCTCCT CCACCAGGCG CTCCACCTCC ATCTCTTATA CCAACAATAG AAAGTGGACA TTCCTCTGGT TATGATAGTC GTTCTGCACG TGCATTTCCA TATGGCAATG TTGCCTTTCC CCATCTTCCT GGTTCTGCTC CTTCGTGGCC TAGTCTTGTG GACACCAGCA AGCAGTGGGA CTATTATGCC AGAAGAGAGA AAGACCGAGA TAGAGAGAGA GACAGAGACA GAGAGCGAGA CCGTGATCGG GACAGAGAAA GAGAACGCAC CAGAGAGAGA GAGAGGGAGC GTGATCACAG TCCTACACCA AGTGTTTTCA ACAGCGATGA AGAACGATAC AGATACAGGG AATATGCAGA AAGAGGTTAT GAGCGTCACA GAGCAAGTCG AGAAAGAGAA GAACGACATA GAGAAAGACG ACACAGGGAG AAAGAGGAAA CCAGACATAA GTCTTCTCGA AGTAATAGTA GACGTCGCCA TGAAAGTGAA GAAGGAGATA GTCACAGGAG ACACAAACAC AAAAAATCTA AAAGAAGCAA AGAAGGAAAA GAAGCGGGCA GTGAGCCTGC CCCTGAACAG GAGAGCACCG AAGCTACACC TGCAGAATAG. It is sometimes possible for the material contained within the vial of "FIP1L1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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