FHIT cdna clone
FHIT cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Description
FHIT: a member of the histidine triad gene family. A diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Its gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. A possible tumor suppressor in specific tissues. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines. Aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas.
Protein type: Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; EC 3.6.1.29; DNA replication; Hydrolase; Tumor suppressor
Chromosomal Location of Human Ortholog: 3p14.2
Cellular Component: cytoplasm; cytosol
Molecular Function: bis(5'-adenosyl)-triphosphatase activity; catalytic activity; hydrolase activity; identical protein binding; protein binding; ubiquitin protein ligase binding
Biological Process: negative regulation of proteasomal ubiquitin-dependent protein catabolic process; nucleotide metabolic process; purine nucleotide metabolic process
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Product Notes
The FHIT fhit (Catalog #AAA1277255) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtcgttca gatttggcca acatctcatc aagccctctg tagtgtttct caaaacagaa ctgtccttcg ctcttgtgaa taggaaacct gtggtaccag gacatgtcct tgtgtgcccg ctgcggccag tggagcgctt ccatgacctg cgtcctgatg aagtggccga tttgtttcag acgacccaga gagtcgggac agtggtggaa aaacatttcc atgggacctc tctcaccttt tccatgcagg atggccccga agccggacag actgtgaagc acgttcacgt ccatgttctt cccaggaagg ctggagactt tcacaggaat gacagcatct atgaggagct ccagaaacat gacaaggagg actttcctgc ctcttggaga tcagaggagg aaatggcagc agaagccgca gctctgcggg tctactttca gtga. It is sometimes possible for the material contained within the vial of "FHIT, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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