FERMT3 cdna clone
FERMT3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]
Uniprot Description
kindlin-3: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3); also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes. Belongs to the kindlin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: membrane; podosome
Molecular Function: integrin binding
Biological Process: integrin activation; integrin-mediated signaling pathway; leukocyte adhesion; positive regulation of cell migration; regulation of cell-cell adhesion mediated by integrin
Disease: Leukocyte Adhesion Deficiency, Type Iii
Research Articles on FERMT3
Similar Products
Product Notes
The FERMT3 fermt3 (Catalog #AAA1268585) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcgggga tgaagacagc ctccggggac tacatcgact cgtcatggga gctgcgggtg tttgtgggag aggaggaccc agaggccgag tcggtcaccc tgcgggtcac tggggagtcg cacatcggcg gggtgctcct gaagattgtg gagcagatca atcgcaagca ggactggtca gaccatgcta tttggtggga acagaagagg cagtggctgc tgcagaccca ctggacactg gacaagtacg ggatcctggc cgacgcacgc ctcttctttg ggccccagca ccggcccgtc atccttcggt tgcccaaccg ccgcgcactg cgcctccgtg ccagcttctc ccagcccctc ttccaggctg tggctgccat ctgccgcctc ctcagcatcc ggcaccccga ggagctgtcc ctgctccggg ctcctgagaa gaaggagaag aagaagaaag agaaggagcc agaggaagag ctctatgact tgagcaaggt tgtcttggct gggggcgtgg cacctgcact gttccggggg atgccagctc acttctcgga cagcgcccag actgaggcct gctaccacat gctgagccgg ccccagccgc cacccgaccc cctcctgctc cagcgtctgc cacggcccag ctccctgtca gacaagaccc agctccacag caggtggctg gactcgtcgc ggtgtctcat gcagcagggc atcaaggctg gggacgcact ctggctgcgc ttcaagtact acagcttctt cgatttggat cccaagacag accccgtgcg gctgacacag ctgtatgagc aggcccggtg ggacctgctg ctggaggaga ttgactgcac cgaggaggag atgatggtgt ttgccgccct gcagtaccac atcaacaagc tgtcccagag cggggaggtg ggggagccgg ctggcacaga cccagggctg gacgacctgg atgtggccct gagcaacctg gaggtgaagc tggaggggtc ggcgcccaca gatgtgctgg acagcctcac caccatccca gagctcaagg accatctccg aatctttcgg ccccggaagc tgaccctgaa gggctaccgc caacactggg tggtgttcaa ggagaccaca ctgtcctact acaagagcca ggacgaggcc cctggggacc ccattcagca gctcaacctc aagggctgtg aggtggttcc cgatgttaac gtctccggcc agaagttctg cattaaactc ctagtgccct cccctgaggg catgagtgag atctacctgc ggtgccagga tgagcagcag tatgcccgct ggatggctgg ctgccgcctg gcctccaaag gccgcaccat ggccgacagc agctacacca gcgaggtgca ggccatcctg gccttcctca gcctgcagcg cacgggcagt gggggcccgg gcaaccaccc ccacggccct gatgcctctg ccgagggcct caacccctac ggcctcgttg ccccccgttt ccagcgaaag ttcaaggcca agcagctcac cccacggatc ctggaagccc accagaatgt ggcccagttg tcgctggcag aggcccagct gcgcttcatc caggcctggc agtccctgcc cgacttcggc atctcctatg tcatggtcag gttcaagggc agcaggaaag acgagatcct gggcatcgcc aacaaccgac tgatccgcat cgacttggcc gtgggcgacg tggtcaagac ctggcgtttc agcaacatgc gccagtggaa tgtcaactgg gacatccggc aggtggccat cgagtttgat gaacacatca atgtggcctt cagctgcgtg tctgccagct gccgaattgt acacgagtat atcgggggct acattttcct gtcgacgcgg gagcgggccc gtggggagga gctggatgaa gacctcttcc tgcagctcac cgggggccat gaggccttct ga. It is sometimes possible for the material contained within the vial of "FERMT3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
