FBXO18 cdna clone

FBXO18 cDNA Clone

Gene Names

FBXO18; FBH1; Fbx18; hFBH1

Synonyms

FBXO18; FBXO18 cDNA Clone; FBXO18 cdna clone

Ordering
Cat. Num. AAA1272436 For Research Use Only!

Sequence

ATGAGACGGTTTAAGCGGAAGCATCTTACTGCCATTGACTGCCAGCATTTGGCTCGGAGTCACTTGGCTGTGACCCAGCCCTTCGGTCAAAGATGGACAAACAGAGATCCGAACCATGGTCTCTATCCTAAACCGAGAACAAAAAGAGGGAGTAGGGGTCAGGGAAGTCAAAGATGCATCCCTGAGTTCTTCCTAGCAGGCAAGCAGCCGTGCACCAATGACATGGCCAAAAGCAATTCTGTTGGCCAGGACAGCTGTCAGGACTCTGAGGGTGACATGATCTTTCCTGCAGAGAGCAGCTGTGCACTGCCTCAGGAAGGCAGTGCAGGGCCGGGCTCACCAGGGTCTGCCCCGCCCTCCAGGAAGCGGTCTTGGTCCTCTGAGGAAGAGAGTAACCAGGCTACCGGGACCAGCCGGTGGGATGGAGTTTCTAAGAAAGCTCCACGGCACCATTTGTCTGTGCCATGCACAAGGCCTAGGGAGGCCAGGCAAGAAGCAGAGGACAGTACGTCTCGGCTCTCTGCGGAGTCTGGTGAAACCGACCAAGATGCTGGGGACGTGGGTCCTGATCCCATTCCTGACTCATACTATGGGCTTCTTGGGACCTTGCCCTGCCAGGAAGCACTGAGCCACATTTGCAGCCTGCCTAGTGAGGTCCTGAGGCACGTGTTTGCCTTCCTCCCGGTGGAAGACCTCTATTGGAACCTGAGCTTGGTGTGCCACTTGTGGAGGGAGATCATCAGTGACCCGCTGTTCATTCCTTGGAAGAAGCTGTACCATCGATACCTGATGAATGAAGAGCAAGCTGTCAGCAAAGTGGACGGCATCCTGTCTAACTGTGGCATAGAAAAGGAGTCAGACCTGTGTGTGCTGAACCTCATACGATACACAGCCACCACTAAGTGCTCTCCGAGTGTGGATCCCGAGAGGGTGCTGTGGAGTCTGAGGGACCACCCCCTCCTCCCCGAGGCTGAGGCGTGTGTGCGGCAACACCTCCCCGACCTCTACGCTGCTGCCGGGGGTGTCAACATCTGGGCCCTGGTGGCGGCTGTGGTGCTCCTCTCCAGCAGTGTGAATGACATCCAGCGACTGCTCTTCTGCCTCCGGAGACCCAGCTCCACGGTGACCATGCCAGATGTCACCGAGACCCTGTACTGCATAGCCGTGCTTCTCTACGCCATGAGGGAGAAGGGGATTAACATCAGCAATAGGATTCACTACAACATTTTCTATTGCCTATATCTTCAGGAGAATTCCTGCACTCAGGCCACAAAAGTTAAAGAGGAGCCATCTGTCTGGCCAGGCAAGAAAACCATCCAACTTACACATGAACAACAGCTGATTCTGAATCACAAGATGGAACCTCTCCAGGTGGTGAAAATTATGGCCTTTGCCGGCACTGGGAAGACCTCAACGCTGGTCAAGTATGCAGAGAAGTGGTCTCAGAGCAGGTTTCTGTATGTGACATTCAACAAGAGCATCGCAAAGCAGGCCGAACGCGTCTTCCCCAGCAACGTCATCTGCAAAACCTTCCACTCCATGGCCTACGGGCACATAGGGCGGAAGTACCAGTCAAAGAAGAAGTTGAATCTCTTCAAGTTAACACCCTTCATGGTCAACTCCGTCCTTGCTGAAGGGAAGGGTGGATTCATAAGAGCCAAGCTTGTGTGTAAGACTCTAGAAAACTTCTTTGCCTCGGCTGACGAAGAGCTGACCATTGATCACGTGCCTATTTGGTGTAAGAACAGCCAAGGACAGAGAGTCATGGTTGAGCAGAGTGAAAAACTGAATGGTGTCCTTGAAGCGAGCCGCCTCTGGGATAACATGCGGAAGCTGGGGGAGTGCACAGAAGAGGCGCACCAGATGACTCATGACGGCTACTTGAAACTCTGGCAGCTGAGCAAGCCTTCGCTGGCCTCTTTTGACGCCATCTTTGTGGATGAGGCCCAGGACTGCACACCAGCTATCATGAACATAGTTCTGTCTCAGCCATGTGGGAAAATCTTTGTAGGGGACCCGCACCAGCAGATCTATACCTTCCGGGGTGCGGTCAACGCCCTGTTCACAGTGCCCCACACCCACGTCTTCTATCTCACGCAGAGTTTTCGGTTTGGTGTGGAAATAGCTTATGTGGGAGCTACTATCTTGGATGTTTGCAAGAGAGTCAGGAAAAAGACTTTGGTTGGAGGAAACCATCAGAGTGGCATTAGAGGTGACGCAAAGGGGCAAGTGGCCTTGTTGTCCCGGACCAACGCCAACGTGTTTGATGAGGCCGTACGGGTGACGGAAGGGGAATTCCCTTCAAGGATACATTTGATTGGGGGGATTAAATCATTTGGATTGGACAGAATCATTGATATTTGGATCCTTCTTCAGCCAGAGGAAGAACGGAGGAAACAAAACCTCGTCATTAAAGACAAATTTATCAGAAGATGGGTGCACAAAGAAGGCTTTAGTGGCTTCAAGAGGTATGTGACCGCTGCCGAGGACAAGGAGCTTGAAGCCAAGATCGCAGTTGTTGAAAAGTATAACATCAGGATTCCAGAGCTGGTGCAAAGGATAGAAAAATGCCATATAGAAGATTTGGACTTTGCAGAGTACATTCTGGGCACTGTGCACAAAGCCAAAGGCCTGGAGTTTGACACTGTGCATGTTTTGGATGATTTTGTGAAAGTGCCTTGTGCCCGGCATAACCTGCCCCAGCTTCCGCACTTCAGAGTTGAGTCATTTTCTGAGGATGAATGGAATTTACTGTATGTTGCAGTAACTCGAGCCAAGAAGCGTCTCATCATGACCAAATCATTGGAAAACATTTTGACTTTGGCTGGGGAGTACTTCTTGCAAGCAGAGCTGACAAGCAACGTCTTAAAAACAGGCGTGGTGCGCTGCTGCGTGGGACAGTGCAACAATGCCATCCCTGTTGACACCGTCCTTACCATGAAGAAGCTGCCCATCACCTATAGCAACAGGAAGGAAAACAAGGGGGGCTACCTCTGCCACTCCTGTGCGGAGCAGCGCATCGGGCCCCTGGCGTTCCTGACAGCCTCCCCGGAGCAGGTGCGCGCCATGGAGCGCACTGTGGAGAACATCGTACTGCCCCGGCATGAGGCCCTGCTCTTCCTCGTCTTCTGA

Sequence Length

3132

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

109731014

NCBI GeneID

84893

Molecular Weight

123,375 Da

NCBI Official Full Name

Homo sapiens F-box protein, helicase, 18, mRNA

NCBI Official Synonym Full Names

F-box protein, helicase, 18

NCBI Official Symbol

FBXO18

NCBI Official Synonym Symbols

FBH1; Fbx18; hFBH1

NCBI Protein Information

F-box DNA helicase 1

UniProt Protein Name

F-box DNA helicase 1

Protein Family

F-box DNA helicase

UniProt Gene Name

FBXO18

UniProt Synonym Gene Names

hFBH1

UniProt Entry Name

FBH1_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FBXO18: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. Belongs to the helicase family. UvrD subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Helicase; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: chromatin; nucleus; SCF ubiquitin ligase complex

Molecular Function: 3'-5' DNA helicase activity; DNA helicase activity; DNA translocase activity; double-stranded DNA binding; protein binding; single-stranded DNA binding

Biological Process: cell death; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; positive regulation of protein amino acid phosphorylation; protein ubiquitination; replication fork processing; replication fork protection; response to DNA damage stimulus

Research Articles on FBXO18

1. FBH1 acts as a negative regulator of RAD51 function in human cells

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Product Notes

The FBXO18 fbxo18 (Catalog #AAA1272436) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGACGGT TTAAGCGGAA GCATCTTACT GCCATTGACT GCCAGCATTT GGCTCGGAGT CACTTGGCTG TGACCCAGCC CTTCGGTCAA AGATGGACAA ACAGAGATCC GAACCATGGT CTCTATCCTA AACCGAGAAC AAAAAGAGGG AGTAGGGGTC AGGGAAGTCA AAGATGCATC CCTGAGTTCT TCCTAGCAGG CAAGCAGCCG TGCACCAATG ACATGGCCAA AAGCAATTCT GTTGGCCAGG ACAGCTGTCA GGACTCTGAG GGTGACATGA TCTTTCCTGC AGAGAGCAGC TGTGCACTGC CTCAGGAAGG CAGTGCAGGG CCGGGCTCAC CAGGGTCTGC CCCGCCCTCC AGGAAGCGGT CTTGGTCCTC TGAGGAAGAG AGTAACCAGG CTACCGGGAC CAGCCGGTGG GATGGAGTTT CTAAGAAAGC TCCACGGCAC CATTTGTCTG TGCCATGCAC AAGGCCTAGG GAGGCCAGGC AAGAAGCAGA GGACAGTACG TCTCGGCTCT CTGCGGAGTC TGGTGAAACC GACCAAGATG CTGGGGACGT GGGTCCTGAT CCCATTCCTG ACTCATACTA TGGGCTTCTT GGGACCTTGC CCTGCCAGGA AGCACTGAGC CACATTTGCA GCCTGCCTAG TGAGGTCCTG AGGCACGTGT TTGCCTTCCT CCCGGTGGAA GACCTCTATT GGAACCTGAG CTTGGTGTGC CACTTGTGGA GGGAGATCAT CAGTGACCCG CTGTTCATTC CTTGGAAGAA GCTGTACCAT CGATACCTGA TGAATGAAGA GCAAGCTGTC AGCAAAGTGG ACGGCATCCT GTCTAACTGT GGCATAGAAA AGGAGTCAGA CCTGTGTGTG CTGAACCTCA TACGATACAC AGCCACCACT AAGTGCTCTC CGAGTGTGGA TCCCGAGAGG GTGCTGTGGA GTCTGAGGGA CCACCCCCTC CTCCCCGAGG CTGAGGCGTG TGTGCGGCAA CACCTCCCCG ACCTCTACGC TGCTGCCGGG GGTGTCAACA TCTGGGCCCT GGTGGCGGCT GTGGTGCTCC TCTCCAGCAG TGTGAATGAC ATCCAGCGAC TGCTCTTCTG CCTCCGGAGA CCCAGCTCCA CGGTGACCAT GCCAGATGTC ACCGAGACCC TGTACTGCAT AGCCGTGCTT CTCTACGCCA TGAGGGAGAA GGGGATTAAC ATCAGCAATA GGATTCACTA CAACATTTTC TATTGCCTAT ATCTTCAGGA GAATTCCTGC ACTCAGGCCA CAAAAGTTAA AGAGGAGCCA TCTGTCTGGC CAGGCAAGAA AACCATCCAA CTTACACATG AACAACAGCT GATTCTGAAT CACAAGATGG AACCTCTCCA GGTGGTGAAA ATTATGGCCT TTGCCGGCAC TGGGAAGACC TCAACGCTGG TCAAGTATGC AGAGAAGTGG TCTCAGAGCA GGTTTCTGTA TGTGACATTC AACAAGAGCA TCGCAAAGCA GGCCGAACGC GTCTTCCCCA GCAACGTCAT CTGCAAAACC TTCCACTCCA TGGCCTACGG GCACATAGGG CGGAAGTACC AGTCAAAGAA GAAGTTGAAT CTCTTCAAGT TAACACCCTT CATGGTCAAC TCCGTCCTTG CTGAAGGGAA GGGTGGATTC ATAAGAGCCA AGCTTGTGTG TAAGACTCTA GAAAACTTCT TTGCCTCGGC TGACGAAGAG CTGACCATTG ATCACGTGCC TATTTGGTGT AAGAACAGCC AAGGACAGAG AGTCATGGTT GAGCAGAGTG AAAAACTGAA TGGTGTCCTT GAAGCGAGCC GCCTCTGGGA TAACATGCGG AAGCTGGGGG AGTGCACAGA AGAGGCGCAC CAGATGACTC ATGACGGCTA CTTGAAACTC TGGCAGCTGA GCAAGCCTTC GCTGGCCTCT TTTGACGCCA TCTTTGTGGA TGAGGCCCAG GACTGCACAC CAGCTATCAT GAACATAGTT CTGTCTCAGC CATGTGGGAA AATCTTTGTA GGGGACCCGC ACCAGCAGAT CTATACCTTC CGGGGTGCGG TCAACGCCCT GTTCACAGTG CCCCACACCC ACGTCTTCTA TCTCACGCAG AGTTTTCGGT TTGGTGTGGA AATAGCTTAT GTGGGAGCTA CTATCTTGGA TGTTTGCAAG AGAGTCAGGA AAAAGACTTT GGTTGGAGGA AACCATCAGA GTGGCATTAG AGGTGACGCA AAGGGGCAAG TGGCCTTGTT GTCCCGGACC AACGCCAACG TGTTTGATGA GGCCGTACGG GTGACGGAAG GGGAATTCCC TTCAAGGATA CATTTGATTG GGGGGATTAA ATCATTTGGA TTGGACAGAA TCATTGATAT TTGGATCCTT CTTCAGCCAG AGGAAGAACG GAGGAAACAA AACCTCGTCA TTAAAGACAA ATTTATCAGA AGATGGGTGC ACAAAGAAGG CTTTAGTGGC TTCAAGAGGT ATGTGACCGC TGCCGAGGAC AAGGAGCTTG AAGCCAAGAT CGCAGTTGTT GAAAAGTATA ACATCAGGAT TCCAGAGCTG GTGCAAAGGA TAGAAAAATG CCATATAGAA GATTTGGACT TTGCAGAGTA CATTCTGGGC ACTGTGCACA AAGCCAAAGG CCTGGAGTTT GACACTGTGC ATGTTTTGGA TGATTTTGTG AAAGTGCCTT GTGCCCGGCA TAACCTGCCC CAGCTTCCGC ACTTCAGAGT TGAGTCATTT TCTGAGGATG AATGGAATTT ACTGTATGTT GCAGTAACTC GAGCCAAGAA GCGTCTCATC ATGACCAAAT CATTGGAAAA CATTTTGACT TTGGCTGGGG AGTACTTCTT GCAAGCAGAG CTGACAAGCA ACGTCTTAAA AACAGGCGTG GTGCGCTGCT GCGTGGGACA GTGCAACAAT GCCATCCCTG TTGACACCGT CCTTACCATG AAGAAGCTGC CCATCACCTA TAGCAACAGG AAGGAAAACA AGGGGGGCTA CCTCTGCCAC TCCTGTGCGG AGCAGCGCAT CGGGCCCCTG GCGTTCCTGA CAGCCTCCCC GGAGCAGGTG CGCGCCATGG AGCGCACTGT GGAGAACATC GTACTGCCCC GGCATGAGGC CCTGCTCTTC CTCGTCTTCT GA. It is sometimes possible for the material contained within the vial of "FBXO18, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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FBXO18 cdna clone