FBXL14 cdna clone

FBXL14

Cat. Num. AAA200968

• Gene Names: FBXL14; Fbl14
• Synonyms: FBXL14; Fbl14; FBXL14 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGAGACCCACATCTCATGCCTGTTCCCGGAGCTGCTGGCCATGATCTTCGGCTACCTGGACGTCCGGGACAAGGGGCGCGCGGCGCAGGTGTGCACCGCCTGGCGGGACGCCGCCTACCACAAGTCGGTGTGGCGGGGGGTGGAGGCCAAGCTGCACCTGCGCCGGGCCAACCCGTCGCTGTTCCCCAGCCTGCAGGCCCGGGGCATCCGCCGGGTGCAGATCCTGAGCCTCCGCCGCAGCCTCAGCTACGTGATCCAGGGCATGGCCAACATCGAGAGCCTCAACCTCAGCGGCTGCTACAACCTCACCGACAACGGGCTGGGCCACGCGTTTGTGCAGGAGATCGGCTCCCTGCGCGCTCTCAACCTGAGCCTCTGCAAGCAGATCACTGACAGCAGCCTGGGCCGCATAGCCCAGTACCTCAAGGGCCTGGAGGTGCTGGAGCTGGGAGGTTGCAGCAACATCACCAACACTGGCCTTCTGCTCATCGCCTGGGGTCTGCAGCGCCTCAAGAGCCTTAACCTCCGCAGCTGCCGCCACCTTTCGGATGTGGGCATCGGGCACCTGGCCGGCATGACGCGCAGCGCGGCGGAGGGCTGCCTGGGCCTGGAGCAGCTCACGCTACAGGACTGCCAGAAGCTCACAGATCTTTCTCTAAAGCACATCTCCCGAGGGCTGACGGGCCTGAGGCTCCTCAACCTCAGCTTCTGTGGGGGAATCTCGGACGCTGGCCTCCTGCACCTGTCGCACATGGGCAGCCTGCGCAGCCTCAACCTGCGCTCCTGTGACAACATCAGTGACACGGGCATCATGCATCTGGCCATGGGCAGCCTGCGCCTCTCGGGGCTGGATGTTTCGTTCTGTGACAAGGTGGGAGACCAGAGTCTGGCTTACATAGCCCAGGGGCTGGATGGCCTCAAGTCTCTCTCCCTCTGCTCCTGCCACATCAGTGATGATGGCATCAACCGCATGGTGCGGCAGATGCACGGGCTGCGCACGCTCAACATTGGACAGTGTGTGCGCATCACGGACAAGGGCCTGGAGCTGATCGCTGAGCACCTGAGCCAACTCACCGGCATAGACCTGTACGGCTGCACCCGAATCACCAAGCGCGGCCTGGAGCGCATCACGCAGCTGCCGTGCCTCAAGGTACTCAACCTGGGACTCTGGCAGATGACGGACAGTGAGAAGGAGGCACGAGGGGATTTTTCTCCATTATTCACTGTGAGAACTCGGGGAAGCTCCAGAAGGTGA; ; Translation Sequence: METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA KLHLRRANPS LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC YNLTDNGLGH AFVQEIGSLR ALNLSLCKQI TDSSLGRIAQ YLKGLEVLEL GGCSNITNTG LLLIAWGLQR LKSLNLRSCR HLSDVGIGHL AGMTRSAAEG CLGLEQLTLQ DCQKLTDLSL KHISRGLTGL RLLNLSFCGG ISDAGLLHLS HMGSLRSLNL RSCDNISDTG IMHLAMGSLR LSGLDVSFCD KVGDQSLAYI AQGLDGLKSL SLCSCHISDD GINRMVRQMH GLRTLNIGQC VRITDKGLEL IAEHLSQLTG IDLYGCTRIT KRGLERITQL PCLKVLNLGL WQMTDSEKEA RGDFSPLFTV RTRGSSRR
• Sequence Length: 418

• Species: Human
• Chromosome Location: 12p13.33
• OMIM Reference Number: 609081
• cDNA Size: 1257bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for FBXL14 cdna clone

FBXL14 is a substrate-recognition component of some SCF (SKP1-CUL1-F-box protein) -type E3 ubiquitin-protein ligase complexes. The SCF (FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.

Product Categories/Family for FBXL14 cdna clone

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 22748931
• NCBI GeneID: 144699
• NCBI Accession #: NP_689654.1
• NCBI GenBank Nucleotide #: NM_152441.2
• UniProt Accession #: Q8N1E6
• NCBI Official Full Name: F-box/LRR-repeat protein 14
• NCBI Official Synonym Full Names: F-box and leucine rich repeat protein 14
• NCBI Official Symbol: FBXL14
• NCBI Official Synonym Symbols: Fbl14
• NCBI Protein Information: F-box/LRR-repeat protein 14
• UniProt Protein Name: F-box/LRR-repeat protein 14
• UniProt Gene Name: FBXL14
• UniProt Synonym Gene Names: FBL14
• UniProt Entry Name: FXL14_HUMAN

NCBI Description

Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]