EIF2C2 cdna clone
EIF2C2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Description
AGO2: the endonuclease in RNA-induced silencing complexes (RISC) that cleaves siRNA/mRNA heteroduplexes bound to RISC. Ago2, along with Dicer and TRBP, are major components of RISC. Interacts with Dicer1 through its Piwi domain. Required for proper fibroblast growth factor signaling during gastrulation. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi).
Protein type: RNA-binding; EC 3.1.26.n2; RNA processing
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: cytoplasm; cytosol; membrane; mRNA cap complex; nucleoplasm; nucleus; polysome; ribonucleoprotein complex
Molecular Function: double-stranded RNA binding; endoribonuclease activity; miRNA binding; protein binding; protein C-terminus binding; RNA 7-methylguanosine cap binding; single-stranded RNA binding; siRNA binding
Biological Process: miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; miRNA-mediated gene silencing, production of miRNAs; negative regulation of translational initiation; phosphoinositide-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; pre-microRNA processing; RNA interference, siRNA loading onto RISC; RNA secondary structure unwinding; RNA-mediated gene silencing; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway
Research Articles on EIF2C2
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Product Notes
The EIF2C2 ago2 (Catalog #AAA1270348) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcccatcc agggccagcc gtgcttctgc aaatacgcgc agggggcgga cagcgtggag cccatgttcc ggcacctgaa gaacacgtat gcgggcctgc agctggtggt ggtcatcctg cccggcaaga cgcccgtgta cgccgaggtc aagcgcgtgg gagacacggt gctggggatg gccacgcagt gcgtgcagat gaagaacgtg cagaggacca cgccacagac cctgtccaac ctctgcctga agatcaacgt caagctggga ggcgtgaaca acatcctgct gccccagggc aggccgccgg tgttccagca gcccgtcatc tttctgggag cagacgtcac tcaccccccc gccggggatg ggaagaagcc ctccattgcc gccgtggtgg gcagcatgga cgcccacccc aatcgctact gcgccaccgt gcgcgtgcag cagcaccggc aggagatcat acaagacctg gccgccatgg tccgcgagct cctcatccag ttctacaagt ccacgcgctt caagcccacc cgcatcatct tctaccgcga cggtgtctct gaaggccagt tccagcaggt tctccaccac gagttgctgg ccatccgtga ggcctgtatc aagctagaaa aagactacca gcccgggatc accttcatcg tggtgcagaa gaggcaccac acccggctct tctgcactga caagaacgag cgggttggga aaagtggaaa cattccagca ggcacgactg tggacacgaa aatcacccac cccaccgagt tcgacttcta cctgtgtagt cacgctggca tccaggggac aagcaggcct tcgcactatc acgtcctctg ggacgacaat cgtttctcct ctgatgagct gcagatccta acctaccagc tgtgtcacac ctacgtgcgc tgcacacgct ccgtgtccat cccagcgcca gcatactacg ctcacctggt ggccttccgg gccaggtacc acctggtgga taaggaacat gacagtgctg aaggaagcca tacctctggg cagagtaacg ggcgagacca ccaagcactg gccaaggcgg tccaggttca ccaagacact ctgcgcacca tgtactttgc ttga. It is sometimes possible for the material contained within the vial of "EIF2C2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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