DOCK4 cdna clone
DOCK4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
DOCK4: Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. Belongs to the DOCK family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Motility/polarity/chemotaxis; GEFs; GEFs, Ras
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component: cytosol; membrane; stereocilium; stereocilium bundle
Molecular Function: GTPase activator activity; PDZ domain binding; protein binding; Rac GTPase binding; receptor tyrosine kinase binding
Research Articles on DOCK4
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Product Notes
The DOCK4 dock4 (Catalog #AAA1269329) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTGGATAC CTACGGAGCA CGAGAAATAC GGCGTGGTTA TTGCCAGTTT CCGAGGAACC GTTCCATATG GCCTGTCATT GGAAATTGGA GATACAGTTC AGATCCTGGA GAAGTGTGAT GGCTGGTACA GAGGATTTGC CTTAAAAAAC CCAAATATCA AGGGTATATT TCCTTCCAGC TACGTTCACT TGAAAAATGC CTGTGTAAAG AACAAAGGAC AATTTGAAAT GGTTATTCCC ACTGAAGACT CTGTTATCAC AGAAATGACA TCAACATTAA GAGACTGGGG AACCATGTGG AAACAACTCT ATGTGCGTAA TGAAGGCGAT CTCTTCCACC GGCTGTGGCA CATCATGAAT GAAATCCTGG ACCTGAGGCG GCAGGTGCTG GTGGGCCACC TCACCCACGA CCGGATGAAG GACGTGAAGC GCCACATTAC TGCCCGGCTT GACTGGGGCA ATGAACAACT GGGACTGGAC CTGGTGCCTA GGAAAGAGTA CGCAATGGTG GATCCGGAAG ACATCAGCAT TACTGAGCTC TACCGATTGA TGGAACATCG ACATCGGAAG AAAGACACCC CGGTGCAGGC CAGCAGTCAC CACCTCTTTG TCCAGATGAA GAGCCTCATG TGTTCCAACC TGGGAGAGGA GCTGGAGGTC ATCTTCTCAC TCTTTGACAG TAAAGAGAAC CGGCCAATCA GTGAGAGATT TTTCTTGAGG CTGAATAGAA ACGGGCTTCC CAAAGCCCCT GATAAACCGG AACGACATTG CTCCCTCTTT GTGGATTTGG GCAGCAGTGA GCTAAGAAAG GACATTTATA TCACCGTGCA CATTATCCGA ATCGGTCGAA TGGGAGCAGG AGAAAAAAAG AATGCCTGTA GTGTCCAGTA CCGACGACCC TTTGGCTGTG CAGTTCTTAG CATCGCTGAC CTGCTAACAG GAGAGACAAA GGATGACCTC ATTCTGAAAG TATACATGTG TAACACAGAG AGTGAGTGGT ACCAAATCCA TGAGAACATC ATCAAAAAGC TGAATGCACG TTATAACTTG ACTGGCTCCA ATGCAGGTTT AGCAGTTTCC TTACAGCTAT TGCACGGAGA CATTGAACAA ATCAGAAGGG AATATTCATC AGTATTTTCT CATGGAGTAT CCATAACAAG GAAGCTGGGA TTTTCAAATA TTATTATGCC TGGTGAAATG AGGAATGATT TATATATCAC TATTGAAAGG GGAGAATTTG AGAAAGGAGG GAAGAGCGTG GCCAGAAATG TGGAAGTTAC GATGTTCATT GTAGACAGTA GTGGCCAAAC CCTGAAGGAT TTTATCTCCT TCGGCTCTGG GGAGCCACCA GCCAGTGAGT ACCACTCCTT TGTGCTTTAC CATAACAACA GTCCCAGGTG GTCTGAACTG CTGAAACTTC CCATTCCTGT GGATAAATTC CGGGGTGCAC ACATCCGCTT CGAGTTTCGG CGTTGTTCCA CAAAGGAGAA AGGAGAGAAG AAGTTGTTTG GGTTTTCTTT TGTCCCTCTG ATGCAAGAAG ATGGTAGGAC TCTTCCAGAT GGCACTCATG AGCTCATCGT GCATAAGTGT GAAGAAAACA CAAATCTTCA GGATACTACC CGCTACCTCA AACTTCCCTT TTCCAAGGGC ATTTTCCTTG GGAATAATAA TCAAGCCATG AAGGCCACAA AGGAGTCCTT TTGTATTACA TCTTTTCTCT GTTCCACAAA ACTCACACAA AATGGTGATA TGCTTGATCT TTTGAAATGG AGAACCCACC CAGACAAGAT CACTGGCTGT CTCTCTAAAT TAAAAGAAAT TGATGGCTCA GAGATAGTAA AGTTTCTGCA GGATACACTG GATACCTTAT TTGGAATTTT AGATGAAAAT TCCCAAAAAT ATGGGTCTAA AGTGTTTGAT TCTTTGGTTC ACATAATAAA TTTGCTGCAA GATAGCAAAT TTCATCATTT TAAACCTGTA ATGGACACTT ACATTGAGAG TCATTTTGCT GGGGCACTTG CATACAGAGA TCTCATCAAA GTGCTCAAAT GGTACGTGGA CCGGATCACA GAAGCAGAGC GGCAAGAGCA TATCCAGGAG GTGCTGAAGG CACAAGAATA CATTTTTAAG TATATAGTTC AATCTCGAAG GCTGTTTTCC CTTGCCACTG GTGGGCAAAA CGAAGAGGAG TTCCGCTGCT GCATTCAGGA GCTTCTCATG TCAGTCCGTT TCTTTCTTTC GCAAGAGAGC AAAGGGTCTG GAGCATTATC TCAGTCACAG GCTGTGTTTC TGAGCTCTTT CCCTGCCGTG TACTCAGAAC TGTTGAAGCT CTTTGATGTC CGGGAAGTAG CCAACTTGGT CCAGGACACC CTGGGCAGTC TGCCGACCAT CCTGCATGTG GATGATTCCC TGCAGGCCAT CAAACTGCAG TGCATTGGCA AAACCGTGGA AAGCCAGCTT TATACCAACC CAGATTCCCG ATACATTCTT CTGCCTGTCG TGTTACATCA CCTCCACATT CACTTGCAAG AACAGAAGGA CCTGATCATG TGTGCACGTA TCCTTAGCAA CGTATTTTGT CTTATCAAGA AAAATAGCTC AGAAAAATCT GTGCTGGAGG AAATAGATGT GATAGTGGCC AGCTTGCTGG ATATTCTGCT GAGGACCATA TTGGAGATCA CCAGCCGACC TCAGCCATCC AGCTCAGCAA TGCGGTTCCA GTTCCAGGAT GTCACTAGAA CAGGCTTTCT GAATAGGGAG TCTTCACATG GCAGTACTAC ATTGAGCACC TTTTCAGTCT GTGCAGACAC ATATGGAAAA GTGCCCATGA CAAGTAGACA CACTGGGGAG TTTGTTGCTT GTCTCCTGTC CCTATTACGA CAAATGACAG ATAGACATTA TCAACAGCTT CTTGATAGTT TTAATACAAA GGAAGAACTA AGGGATTTCC TGCTGCAGAT ATTTACTGTG TTCCGAATAT TGATACGCCC GGAGATGTTT CCAAAGGACT GGACTGTTAT GCGCTTGGTT GCTAACAATG TTATTATTAC AACAGTTCTA TACCTCTCAG ATGCACTTCG TAAGAACTTC TTAAATGAAA ACCTTGATTA TAAGATCTGG GATTCCTACT TTTACCTCGC AGTCATTTTT ATAAACCAGT TGTGTCTGCA GTTGGAGATG TTCACACCTT CCAAGAAGAA AAAGGTGTTA GAAAAGTATG GTGACATGCG GGTAACAATG GGTTGTGAAA TTTTCAGCAT GTGGCAAAAC CTAGGAGAGC ACAAGCTTCA TTTTATCCCT GCCCTGATTG GCCCCTTCCT AGAAGTGACC TTGATACCCC AGCCAGATCT TCGGAATGTC ATGATTCCAA TTTTTCATGA TATGATGGAC TGGGAGCAGA GGCGGAGTGG CAACTTTAAA CAGGTGGAAG CCAAGCTAAT TGACAAACTG GATAGCCTGA TGTCAGAAGG CAAAGGTGAC GAAACATACC GCGAGCTCTT CAACAGTATA ATTCCACTAT TTGGTCCCTA TCCTAGTCTA CTAAAGAAAA TTGAGCGGGA AACATGGCGG GAAAGTGGCG TTTCATTAAT TGCTACTGTA ACTCGTCTAA TGGAGAGGTT GTTAGATTAC AGGGACTGCA TGAAAATGGG AGAGGTAGAT GGCAAAAAGA TTGGCTGCAC AGTTAGCCTT CTGAACTTCT ATAAGACTGA ACTGAACAAG GAGGAGATGT ATATACGCTA CATTCACAAA CTCTATGATC TGCATCTCAA AGCACAGAAC TTTACAGAAG CTGCATATAC CCTCCTCTTA TATGACGAGC TACTGGAATG GTCTGATCGG CCCCTCAGGG AGTTCCTGAC CTACCCCATG CAAACAGAAT GGCAGCGCAA AGAGCACCTG CACCTCACCA TCATCCAGAA CTTTGACAGA GGCAAATGTT GGGAGAATGG CATTATCTTG TGCCGGAAGA TTGCAGAGCA GTATGAGAGT TATTATGACT ACAGAAACCT GAGCAAGATG CGGATGATGG AAGCCTCTTT GTATGACAAA ATTATGGACC AGCAACGTCT TGAACCAGAG TTCTTCAGAG TTGGATTTTA TGGAAAAAAA TTTCCATTTT TCTTAAGAAA TAAGGAGTTT GTGTGTCGAG GGCATGACTA CGAGAGGCTG GAAGCCTTCC AACAGAGAAT GCTGAACGAG TTCCCCCATG CCATCGCCAT GCAGCACGCC AACCAGCCCG ATGAGACCAT CTTCCAGGCA GAAGCTCAGT ATTTGCAGAT ATATGCTGTG ACTCCCATTC CAGAGAGCCA GGAGGTCCTG CAGAGAGAGG GTGTTCCGGA CAACATCAAA AGCTTCTATA AAGTGAATCA CATCTGGAAA TTCCGCTATG ACCGACCATT TCACAAAGGC ACAAAAGATA AAGAGAATGA ATTCAAGAGT CTCTGGGTGG AGAGAACGTC ATTATACTTG GTGCAGAGTT TGCCTGGCAT CTCTCGCTGG TTTGAAGTGG AAAAGCGTGA AGTGGTAGAA ATGAGTCCTC TGGAAAATGC AATTGAAGTG CTAGAAAATA AGAATCAGCA GCTGAAGACT CTGATTAGTC AGTGTCAGAC AAGACAGATG CAGAATATTA ATCCCCTGAC TATGTGCCTG AATGGAGTTA TAGATGCTGC AGTTAATGGT GGCGTTTCCA GGTATCAAGA GGCATTCTTT GTCAAAGAAT ATATCTTAAG TCACCCTGAA GATGGGGAGA AAATTGCACG ATTAAGAGAG CTGATGCTTG AGCAGGCACA GATTCTGGAA TTTGGTTTGG CCGTGCATGA GAAGTTTGTA CCTCAAGATA TGAGACCCCT TCACAAAAAG CTGGTTGACC AATTCTTTGT GATGAAGTCG AGCTTAGGGA TACAGGAGTT CTCTGCTTGT ATGCAAGCCA GTCCTGTCCA TTTTCCTAAT GGAAGCCCTC GTGTGTGTAG AAACTCAGCA CCTGCTTCTG TGAGCCCAGA TGGTACCAGG GTAATTCCTA GACGCAGCCC GTTAAGTTAC CCAGCTGTCA ACCGATATTC TTCCTCCTCA CTGTCCTCAC AAGCTTCTGC TGAAGTAAGC AATATTACAG GGCAATCAGA AAGCTCTGAT GAAGTCTTTA ACATGCAGCC AAGTCCATCT ACCTCAAGCT TGAGTTCTAC TCACTCGGCT TCACCTAATG TGACAAGTTC TGCTCCATCG AGTGCCAGAG CTTCTCCTTT GTTGTCTGAC AAACACAAAC ATTCCCGAGA AAACTCTTGC CTGTCACCAA GAGAGAGACC ATGCAGTGCC ATCTATCCAA CACCTGTGGA GCCTTCGCAG AGGATGCTGT TTAATCATAT TGGAGACGGG GCCTTGCCAC GCAGTGACCC AAATCTCTCT GCACCTGAAA AAGCTGTGAA CCCCACCCCT AGCAGCTGGA GCCTGGACAG TGGGAAGGAA GCCAAGAACA TGTCGGATAG TGGGAAACTT ATCTCTCCCC CTGTCCCTCC AAGACCCACA CAGACTGCTT CACCAGCAAG ACACACGACA TCAGTATCCC CCTCGCCTGC CGGGCGATCT CCATTGAAGG GCTCTGTGCA GTCTTTCACC CCCTCTCCAG TGGAGTACCA CTCGCCAGGA CTCATCTCCA ACTCCCCTGT CTTGTCGGGC AGCTACAGCA GTGGGATTTC TTCTCTCAGC CGGTGCAGCA CGTCGGAAAC CTCAGGCTTT GAAAATCAGG TGAATGAACA GTCGGCCCCC CTGCCGGTGC CAGTGCCGGT GCCCGTGCCG AGCTACGGCG GGGAGGAGCC AGTGCGCAAG GAGAGCAAGA CTCCGCCCCC GTACAGCGTC TACGAGCGGA CTCTGCGGCG CCCCATCCCG CTACCTCACA GCCTCTCCAT CCCCGTCACG TCGGAGCCGC CCGCGCTGCC CCCCAAGCCT CTGGCAGCGC GATCCAGCCA CCTGGAGAAT GGGGCCCGGA GGACTGACCC CGGCCCGCGG CCCAGGCCCC TGCCCCGCAA GGTCTCTCAG TTATAA. It is sometimes possible for the material contained within the vial of "DOCK4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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