DNMT3A cdna clone
DNMT3A cDNA Clone
Gene Names
DNMT3A; TBRS; DNMT3A2; M.HsaIIIA
Synonyms
DNMT3A; DNMT3A cDNA Clone; DNMT3A cdna clone
Sequence
atgcccgccatgccctccagcggccccggggacaccagcagctctgctgcggagcgggaggaggaccgaaaggacggagaggagcaggaggagccgcgtggcaaggaggagcgccaagagcccagcaccacggcacggaaggtggggcggcctgggaggaagcgcaagcaccccccggtggaaagcggtgacacgccaaaggaccctgcggtgatctccaagtccccatccatggcccaggactcaggcgcctcagagctattacccaatggggacttggagaagcggagtgagccccagccagaggaggggagccctgctggggggcagaagggcggggccccagcagagggagagggtgcagctgagaccctgcctgaagcctcaagagcagtggaaaatggctgctgcacccccaaggagggccgaggagcccctgcagaagcgggcaaagaacagaaggagaccaacatcgaatccatgaaaatggagggctcccggggccggctgcggggtggcttgggctgggagtccagcctccgtcagcggcccatgccgaggctcaccttccaggcgggggacccctactacatcagcaagcgcaagcgggacgagtggctggcacgctggaaaagggaggctgagaagaaagccaaggtcattgcaggaatgaatgctgtggaagaaaaccaggggcccggggagtctcagaaggtggaggaggccagccctcctgctgtgcagcagcccactgaccccgcatcccccactgtggctaccacgcctgagcccgtggggtccgatgctggggacaagaatgccaccaaagcaggcgatgacgagccagagtacgaggacggccggggctttggcattggggagctggtgtgggggaaactgcggggcttctcctggtggccaggccgcattgtgtcttggtggatgacgggccggagccgagcagctgaaggcacccgctgggtcatgtggttcggagacggcaaattctcagtggtgtgtgttgagaagctgatgccgctgagctcgttttgcagtgcgttccaccaggccacgtacaacaagcagcccatgtaccgcaaagccatctacgaggtcctgcaggtggccagcagccgcgcggggaagctgttcccggtgtgccacgacagcgatgagagtgacactgccaaggccgtggaggtgcagaacaagcccatgattgaatgggccctggggggcttccagccttctggccctaagggcctggagccaccagaagaagagaagaatccctacaaagaagtgtacacggacatgtgggtggaacctgaggcagctgcctacgcaccacctccaccagccaaaaagccccggaagagcacagcggagaagcccaaggtcaaggagattattgatgagcgcacaagagagcggctggtgtacgaggtgcggcagaagtgccggaacattgaggacatctgcatctcctgtgggagcctcaatgttaccctggaacaccccctcttcgttggaggaatgtgccaaaactgcaagaactgctttctggagtgtgcgtaccagtacgacgacgacggctaccagtcctactgcaccatctgctgtgggggccgtgaggtgctcatgtgcggaaacaacaactgctgcaggtgcttttgcgtggagtgtgtggacctcttggtggggccgggggctgcccaggcagccattaaggaagacccctggaactgctacatgtgcgggcacaagggtacctacgggctgctgcggcggcgagaggactggccctcccggctccagatgttcttcgctaataaccacgaccaggaatttgaccctccaaaggtttacccacctgtcccagctgagaagaggaagcccatccgggtgctgtctctctttgatggaatcgctacagggctcctggtgctgaaggacttgggcattcaggtggaccgctacattgcctcggaggtgtgtgaggactccatcacggtgggcatggtgcggcaccaggggaagatcatgtacgtcggggacgtccgcagcgtcacacagaagcatatccaggagtggggcccattcgatctggtgattgggggcagtccctgcaatgacctctccatcgtcaaccctgctcgcaagggcctctacgagggcactggccggctcttctttgagttctaccgcctcctgcatgatgcgcggcccaaggagggagatgatcgccccttcttctggctctttgagaatgtggtggccatgggcgttagtgacaagagggacatctcgcgatttctcgagtccaaccctgtgatgattgatgccaaagaagtgtcagctgcacacagggcccgctacttctggggtaaccttcccggtatgaacaggccgttggcatccactgtgaatgataagctggagctgcaggagtgtctggagcatggcaggatagccaagttcagcaaagtgaggaccattactacgaggtcaaactccataaagcagggcaaagaccagcattttcctgtcttcatgaatgagaaagaggacatcttatggtgcactgaaatggaaagggtatttggtttcccagtccactatactgacgtctccaacatgagccgcttggcgaggcagagactgctgggccggtcatggagcgtgccagtcatccgccacctcttcgctccgctgaaggagtattttgcgtgtgtgtaa
Sequence Length
2739
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
16,866 Da
NCBI Official Full Name
Homo sapiens DNA (cytosine-5-)-methyltransferase 3 alpha, mRNA
NCBI Official Synonym Full Names
DNA methyltransferase 3 alpha
NCBI Official Symbol
DNMT3A
NCBI Official Synonym Symbols
TBRS; DNMT3A2; M.HsaIIIA
NCBI Protein Information
DNA (cytosine-5)-methyltransferase 3A
UniProt Protein Name
DNA (cytosine-5)-methyltransferase 3A
Protein Family
UniProt Gene Name
DNMT3A
UniProt Synonym Gene Names
Dnmt3a; DNA MTase HsaIIIA; M.HsaIIIA
UniProt Entry Name
DNM3A_HUMAN
NCBI Description
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Uniprot Description
DNMT3A: a DNA methyltransferase required for genome wide de novo methylation and essential for development. DNA methylation is coordinated with methylation of histones. Prefers CpG methylation to CpA, CpT, and CpC methylation. Methylates CpG sites at a rate much slower than DNMT1, but greater than DNMT3b. Methylation is coordinated with methylation of histones. Binds the ZNF238 transcriptional repressor. Interacts with SETDB1 and DNMT1. Can co-localize with heterochromatin protein (HP1 ) and methyl-CpG binding protein (MeCBP). Associates with HDAC1 through its ADD-type zinc-finger. Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Protein type: EC 2.1.1.37; Amino Acid Metabolism - cysteine and methionine; Methyltransferase, DNA; Methyltransferase
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: cytoplasm; euchromatin; nuclear matrix; nucleoplasm; nucleus
Molecular Function: DNA (cytosine-5-)-methyltransferase activity; DNA binding; DNA-methyltransferase activity; identical protein binding; protein binding
Biological Process: DNA methylation; genetic imprinting; negative regulation of gene expression, epigenetic
Disease: Tatton-brown-rahman Syndrome
Research Articles on DNMT3A
Similar Products
Product Notes
The DNMT3A dnmt3a (Catalog #AAA1270923) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcccgcca tgccctccag cggccccggg gacaccagca gctctgctgc ggagcgggag gaggaccgaa aggacggaga ggagcaggag gagccgcgtg gcaaggagga gcgccaagag cccagcacca cggcacggaa ggtggggcgg cctgggagga agcgcaagca ccccccggtg gaaagcggtg acacgccaaa ggaccctgcg gtgatctcca agtccccatc catggcccag gactcaggcg cctcagagct attacccaat ggggacttgg agaagcggag tgagccccag ccagaggagg ggagccctgc tggggggcag aagggcgggg ccccagcaga gggagagggt gcagctgaga ccctgcctga agcctcaaga gcagtggaaa atggctgctg cacccccaag gagggccgag gagcccctgc agaagcgggc aaagaacaga aggagaccaa catcgaatcc atgaaaatgg agggctcccg gggccggctg cggggtggct tgggctggga gtccagcctc cgtcagcggc ccatgccgag gctcaccttc caggcggggg acccctacta catcagcaag cgcaagcggg acgagtggct ggcacgctgg aaaagggagg ctgagaagaa agccaaggtc attgcaggaa tgaatgctgt ggaagaaaac caggggcccg gggagtctca gaaggtggag gaggccagcc ctcctgctgt gcagcagccc actgaccccg catcccccac tgtggctacc acgcctgagc ccgtggggtc cgatgctggg gacaagaatg ccaccaaagc aggcgatgac gagccagagt acgaggacgg ccggggcttt ggcattgggg agctggtgtg ggggaaactg cggggcttct cctggtggcc aggccgcatt gtgtcttggt ggatgacggg ccggagccga gcagctgaag gcacccgctg ggtcatgtgg ttcggagacg gcaaattctc agtggtgtgt gttgagaagc tgatgccgct gagctcgttt tgcagtgcgt tccaccaggc cacgtacaac aagcagccca tgtaccgcaa agccatctac gaggtcctgc aggtggccag cagccgcgcg gggaagctgt tcccggtgtg ccacgacagc gatgagagtg acactgccaa ggccgtggag gtgcagaaca agcccatgat tgaatgggcc ctggggggct tccagccttc tggccctaag ggcctggagc caccagaaga agagaagaat ccctacaaag aagtgtacac ggacatgtgg gtggaacctg aggcagctgc ctacgcacca cctccaccag ccaaaaagcc ccggaagagc acagcggaga agcccaaggt caaggagatt attgatgagc gcacaagaga gcggctggtg tacgaggtgc ggcagaagtg ccggaacatt gaggacatct gcatctcctg tgggagcctc aatgttaccc tggaacaccc cctcttcgtt ggaggaatgt gccaaaactg caagaactgc tttctggagt gtgcgtacca gtacgacgac gacggctacc agtcctactg caccatctgc tgtgggggcc gtgaggtgct catgtgcgga aacaacaact gctgcaggtg cttttgcgtg gagtgtgtgg acctcttggt ggggccgggg gctgcccagg cagccattaa ggaagacccc tggaactgct acatgtgcgg gcacaagggt acctacgggc tgctgcggcg gcgagaggac tggccctccc ggctccagat gttcttcgct aataaccacg accaggaatt tgaccctcca aaggtttacc cacctgtccc agctgagaag aggaagccca tccgggtgct gtctctcttt gatggaatcg ctacagggct cctggtgctg aaggacttgg gcattcaggt ggaccgctac attgcctcgg aggtgtgtga ggactccatc acggtgggca tggtgcggca ccaggggaag atcatgtacg tcggggacgt ccgcagcgtc acacagaagc atatccagga gtggggccca ttcgatctgg tgattggggg cagtccctgc aatgacctct ccatcgtcaa ccctgctcgc aagggcctct acgagggcac tggccggctc ttctttgagt tctaccgcct cctgcatgat gcgcggccca aggagggaga tgatcgcccc ttcttctggc tctttgagaa tgtggtggcc atgggcgtta gtgacaagag ggacatctcg cgatttctcg agtccaaccc tgtgatgatt gatgccaaag aagtgtcagc tgcacacagg gcccgctact tctggggtaa ccttcccggt atgaacaggc cgttggcatc cactgtgaat gataagctgg agctgcagga gtgtctggag catggcagga tagccaagtt cagcaaagtg aggaccatta ctacgaggtc aaactccata aagcagggca aagaccagca ttttcctgtc ttcatgaatg agaaagagga catcttatgg tgcactgaaa tggaaagggt atttggtttc ccagtccact atactgacgt ctccaacatg agccgcttgg cgaggcagag actgctgggc cggtcatgga gcgtgccagt catccgccac ctcttcgctc cgctgaagga gtattttgcg tgtgtgtaa. It is sometimes possible for the material contained within the vial of "DNMT3A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
